5,15-DIPHENYL-21H,23H-PORPHINE
Uses- Product Name
- 5,15-DIPHENYL-21H,23H-PORPHINE
- CAS No.
- 22112-89-6
- Chemical Name
- 5,15-DIPHENYL-21H,23H-PORPHINE
- Synonyms
- 5,15-DPP;5,15-DIPHENYLPORPHINE;5,15-Diphenylporphyrin;5,15-Diphenylporphyrin>5, 15-BIS-(PHENYL)PORPHYRINS;5,15-DIPHENYL-21H,23H-PORPHINE;Stat3 Inhibitor VIII, 5,15-DPP;21H,23H-Porphine, 5,15-diphenyl-;5,15-Bis-(phenyl)-21H,23H-porphyrins;5,15-diphenyl-21,23-dihydroporphyrin
- CBNumber
- CB6487713
- Molecular Formula
- C32H22N4
- Formula Weight
- 462.54
- MOL File
- 22112-89-6.mol
5,15-DIPHENYL-21H,23H-PORPHINE Property
- Melting point:
- >200℃
- Boiling point:
- 912.3±65.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- ≤2mg/ml in dimethyl formamide
- form
- Deep blue to deep purple solid
- color
- Red to Dark blue to Black
Safety
- WGK Germany
- 3
- HS Code
- 2933.99.8290
- HazardClass
- IRRITANT
N-Bromosuccinimide Price
- Product number
- D4071
- Product name
- 5, 15-DPP
- Packaging
- 10mg
- Price
- $90
- Updated
- 2025/07/31
- Product number
- 573109
- Product name
- STAT3 Inhibitor VIII, 5,15-DPP
- Packaging
- 25mg
- Price
- $140
- Updated
- 2023/01/07
- Product number
- D2860
- Product name
- 5,15-Diphenylporphyrin
- Purity
- >90.0%(HPLC)
- Packaging
- 100mg
- Price
- $300
- Updated
- 2025/07/31
- Product number
- 16090
- Product name
- 5, 15-DPP
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16090
- Product name
- 5, 15-DPP
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $109
- Updated
- 2024/03/01
5,15-DIPHENYL-21H,23H-PORPHINE Chemical Properties,Usage,Production
Uses
5,15-Diphenylporphyrin (cas# 22112-89-6) is a useful research chemical.
Uses
5, 15-DPP has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
- to analyze its effects on malignant peripheral nerve sheath tumor (MPNST) survival and proliferation
- to study its effects on the thymic stromal lymphopoietin (TSLP) modulation of nometastatic gene 23-H1 (NME1 or nm23-H1) expression in human trophoblasts
- to study its effects on 17β-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced M2 polarization in human macrophages and endometrial stromal cells
Biological Activity
5,15-diphenylporphyrin (5,15-dpp) is a selective stat3-sh2 antagonist [1].stat3 is constitutively activated in many human cancers. stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis [2]. aberrant stat3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases [1].
in vitro
5,15-dpp directly bound to stat3 and antagonized the function of stat3-sh2. 5,15-dpp selectively antagonized stat3-sh2 with an ic50 of 0.28 μm over the other sh2-containing proteins stat1 and grb2[1]. the estimated kd values for the 5,15-dpp binding to stat3 was 880 nm. treatment with 5,15-dpp suppressed the dna binding activity of stat3 in a concentration-dependent manner. 5,15-dpp poorly inhibited stat1 with an ic50 of 10 μm and showed no effect grb2 [1].
References
[1] uehara y, mochizuki m, matsuno k, et al. novel high-throughput screening system for identifying stat3–sh2 antagonists[j]. biochemical and biophysical research communications, 2009, 380(3): 627-631.
[2] jing n, tweardy d j. targeting stat3 in cancer therapy[j]. anti-cancer drugs, 2005, 16(6): 601-607.
5,15-DIPHENYL-21H,23H-PORPHINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,15-DIPHENYL-21H,23H-PORPHINE manufacturers
- Product
- 5,15-Diphenyl-21H,23H-porphine 22112-89-6
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 90%
- Supply Ability
- 20 tons
- Release date
- 2025-07-24