ChemicalBook > CAS DataBase List > 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR

7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR

Product Name
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
CAS No.
213743-31-8
Chemical Name
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
Synonyms
RK-24466;KIN001-051;KIN 001-51;d]pyrimidin-4-ylamine;RK-24466 ;RK 24466 ;RK24466;7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR;Lck Inhibitor - CAS 213743-31-8 - Calbiochem;RK-24466,Src,Inhibitor,inhibit,RK 24466,RK24466;7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;4-Amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine
CBNumber
CB6497372
Molecular Formula
C23H22N4O
Formula Weight
370.45
MOL File
213743-31-8.mol
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7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Property

Boiling point:
605.1±55.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 17 mg/mL at ≤60 °C, soluble
form 
White solid
pka
5.75±0.30(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8863
Product name
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3?d]pyrimidin-4-ylamine
Purity
≥98% (HPLC)
Packaging
5mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
15135
Product name
LCK Inhibitor
Purity
≥95%
Packaging
500 μg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
15135
Product name
Lck Inhibitor
Purity
≥95%
Packaging
1mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
15135
Product name
Lck Inhibitor
Purity
≥95%
Packaging
5mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
15135
Product name
LCK Inhibitor
Purity
≥95%
Packaging
10mg
Price
$346
Updated
2024/03/01
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7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Chemical Properties,Usage,Production

Uses

Lck Inhibitor is a cell-permeable ATP-competitive inhibitor of Lck.

Definition

ChEBI: RK-24466 is a member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by amino, 4-phenoxyphenyl, and cyclopentyl groups at positions 4, 5 and 7, respectively. It is a potent inhibitor of Lck that inhibits Lck (64-509) and LckCD isoforms (IC50 of less than 1 and 2 nM, respectively). It has a role as a geroprotector and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a primary amino compound, a pyrrolopyrimidine, an aromatic amine, an aromatic ether and a member of cyclopentanes.

General Description

A cell-permeable pyrrolopyrimidine compound that acts as a potent, reversible, selective, and ATP-competitive inhibitor of Lck (IC50 at 5 μM ATP = <1 nM, 2 nM, 70 nM, 1.57 μM and 1.98 μM for lck64-509 Y394, Lckcd pY394, Src, Kdr and Tie-2, respectively; IC50 at 1 mM ATP = 16 μM, 66 nM, 126 nM, 420 nM and 5.18 μM for Lck64-509 Y394, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC50 = 3.2 μM, >33 μM, >50 μM and >50 μM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro (IC50<1-40 nM in Jurkat T cells) and in vivo (ED50 = 4 mg/kg in mice, ip.)

Biochem/physiol Actions

Primary TargetLck?????? Y3

7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Preparation Products And Raw materials

Raw materials

Preparation Products

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7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Suppliers

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213743-31-8, 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYRRelated Search:


  • 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • RK-24466 ;RK 24466 ;RK24466
  • Lck Inhibitor - CAS 213743-31-8 - Calbiochem
  • d]pyrimidin-4-ylamine
  • RK-24466
  • 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
  • KIN 001-51
  • 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-cyclopentyl-5-(4-phenoxyphenyl)-
  • KIN001-051
  • RK-24466,Src,Inhibitor,inhibit,RK 24466,RK24466
  • 4-Amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine
  • 213743-31-8
  • LckNon-Receptor Tyrosine Kinase Biology
  • Lymphocyte Specific Kinase (Lck)Cell Signaling and Neuroscience
  • Non-Receptor Tyrosine Kinase Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Kinase/Phosphatase Biology
  • L to
  • Protein Kinase Inhibitors