ChemicalBook > CAS DataBase List > 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR

7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR

Product Name
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
CAS No.
213743-31-8
Chemical Name
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
Synonyms
RK-24466;KIN001-051;KIN 001-51;d]pyrimidin-4-ylamine;RK-24466 ;RK 24466 ;RK24466;7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR;Lck Inhibitor - CAS 213743-31-8 - Calbiochem;RK-24466,Src,Inhibitor,inhibit,RK 24466,RK24466;7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;4-Amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine
CBNumber
CB6497372
Molecular Formula
C23H22N4O
Formula Weight
370.45
MOL File
213743-31-8.mol
More
Less

7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Property

Boiling point:
605.1±55.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 17 mg/mL at ≤60 °C, soluble
form 
White solid
pka
5.75±0.30(Predicted)
color 
white
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8863
Product name
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3?d]pyrimidin-4-ylamine
Purity
≥98% (HPLC)
Packaging
5mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
15135
Product name
LCK Inhibitor
Purity
≥95%
Packaging
500 μg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
15135
Product name
Lck Inhibitor
Purity
≥95%
Packaging
1mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
15135
Product name
Lck Inhibitor
Purity
≥95%
Packaging
5mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
15135
Product name
LCK Inhibitor
Purity
≥95%
Packaging
10mg
Price
$346
Updated
2024/03/01
More
Less

7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Chemical Properties,Usage,Production

Uses

Lck Inhibitor is a cell-permeable ATP-competitive inhibitor of Lck.

Definition

ChEBI: RK-24466 is a member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by amino, 4-phenoxyphenyl, and cyclopentyl groups at positions 4, 5 and 7, respectively. It is a potent inhibitor of Lck that inhibits Lck (64-509) and LckCD isoforms (IC50 of less than 1 and 2 nM, respectively). It has a role as a geroprotector and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a primary amino compound, a pyrrolopyrimidine, an aromatic amine, an aromatic ether and a member of cyclopentanes.

General Description

A cell-permeable pyrrolopyrimidine compound that acts as a potent, reversible, selective, and ATP-competitive inhibitor of Lck (IC50 at 5 μM ATP = <1 nM, 2 nM, 70 nM, 1.57 μM and 1.98 μM for lck64-509 Y394, Lckcd pY394, Src, Kdr and Tie-2, respectively; IC50 at 1 mM ATP = 16 μM, 66 nM, 126 nM, 420 nM and 5.18 μM for Lck64-509 Y394, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC50 = 3.2 μM, >33 μM, >50 μM and >50 μM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro (IC50<1-40 nM in Jurkat T cells) and in vivo (ED50 = 4 mg/kg in mice, ip.)

Biochem/physiol Actions

Primary TargetLck?????? Y3

7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Suppliers

Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7296
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Jiangsu aikang biomedical research and development co., LTD
Tel
025-66110311 13155353615
Email
qzhang@aikonchem.com
Country
China
ProdList
15527
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30239
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 18108052721
Email
2850505130@qq.com
Country
China
ProdList
5176
Advantage
58
Jingmo (Xiamen) Biotechnology Co., Ltd
Tel
13621943973; 13621943973
Email
sales@jamxmpharmatech.com
Country
China
ProdList
1111
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44806
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44458
Advantage
58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4315
Advantage
58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Fax
18003835034(微信)
Email
2853979819@qq.com
Country
China
ProdList
9732
Advantage
58
ChemeGen 中国
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62075
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ:2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054 13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
9470
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
6813
Advantage
58
Shanghai AMINO Biotechnology Co., Ltd
Tel
17302153218
Email
1743952078@qq.com
Country
China
ProdList
700
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29979
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
SY06@accelachem.com
Country
China
ProdList
8118
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12005
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
32957
Advantage
60
LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
43340
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054
Email
trendseenbio@gmail.com
Country
China
ProdList
11681
Advantage
58
Nanjing Doge Biomedical Technology Co., Ltd
Tel
+86-25-58227606 +86-15305155328
Email
sales@dogechemical.com
Country
China
ProdList
4128
Advantage
58
Shanghai Machine Pure Industrial Co., Ltd.
Tel
--
Fax
--
Email
3245176082@qq.com
Country
CHINA
ProdList
6800
Advantage
58
Jiangxi Jianglan Pure Biological Reagent Co., Ltd.
Tel
--
Fax
--
Email
3245176082@qq.com
Country
CHINA
ProdList
6134
Advantage
58
Shanghai Wowu Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shhebio@126.com
Country
CHINA
ProdList
6137
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Guangzhou WeiBo Chemical Co., Ltd.
Tel
--
Fax
--
Email
weibochem@163.com
Country
China
ProdList
6187
Advantage
67

213743-31-8, 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYRRelated Search:


  • 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • RK-24466 ;RK 24466 ;RK24466
  • Lck Inhibitor - CAS 213743-31-8 - Calbiochem
  • d]pyrimidin-4-ylamine
  • RK-24466
  • 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
  • KIN 001-51
  • 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-cyclopentyl-5-(4-phenoxyphenyl)-
  • KIN001-051
  • RK-24466,Src,Inhibitor,inhibit,RK 24466,RK24466
  • 4-Amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine
  • 213743-31-8
  • LckNon-Receptor Tyrosine Kinase Biology
  • Lymphocyte Specific Kinase (Lck)Cell Signaling and Neuroscience
  • Non-Receptor Tyrosine Kinase Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Kinase/Phosphatase Biology
  • L to
  • Protein Kinase Inhibitors