7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
- Product Name
- 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
- CAS No.
- 213743-31-8
- Chemical Name
- 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
- Synonyms
- RK-24466;KIN001-051;KIN 001-51;d]pyrimidin-4-ylamine;RK-24466 ;RK 24466 ;RK24466;7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR;Lck Inhibitor - CAS 213743-31-8 - Calbiochem;RK-24466,Src,Inhibitor,inhibit,RK 24466,RK24466;7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;4-Amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine
- CBNumber
- CB6497372
- Molecular Formula
- C23H22N4O
- Formula Weight
- 370.45
- MOL File
- 213743-31-8.mol
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Property
- Boiling point:
- 605.1±55.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 17 mg/mL at ≤60 °C, soluble
- form
- White solid
- pka
- 5.75±0.30(Predicted)
- color
- white
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C8863
- Product name
- 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3?d]pyrimidin-4-ylamine
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 15135
- Product name
- LCK Inhibitor
- Purity
- ≥95%
- Packaging
- 500 μg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 15135
- Product name
- Lck Inhibitor
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $95
- Updated
- 2024/03/01
- Product number
- 15135
- Product name
- Lck Inhibitor
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 15135
- Product name
- LCK Inhibitor
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $346
- Updated
- 2024/03/01
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Chemical Properties,Usage,Production
Uses
Lck Inhibitor is a cell-permeable ATP-competitive inhibitor of Lck.
Definition
ChEBI: RK-24466 is a member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by amino, 4-phenoxyphenyl, and cyclopentyl groups at positions 4, 5 and 7, respectively. It is a potent inhibitor of Lck that inhibits Lck (64-509) and LckCD isoforms (IC50 of less than 1 and 2 nM, respectively). It has a role as a geroprotector and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a primary amino compound, a pyrrolopyrimidine, an aromatic amine, an aromatic ether and a member of cyclopentanes.
General Description
A cell-permeable pyrrolopyrimidine compound that acts as a potent, reversible, selective, and ATP-competitive inhibitor of Lck (IC50 at 5 μM ATP = <1 nM, 2 nM, 70 nM, 1.57 μM and 1.98 μM for lck64-509 Y394, Lckcd pY394, Src, Kdr and Tie-2, respectively; IC50 at 1 mM ATP = 16 μM, 66 nM, 126 nM, 420 nM and 5.18 μM for Lck64-509 Y394, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC50 = 3.2 μM, >33 μM, >50 μM and >50 μM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro (IC50<1-40 nM in Jurkat T cells) and in vivo (ED50 = 4 mg/kg in mice, ip.)
Biochem/physiol Actions
Primary TargetLck?????? Y3