(3β,24S)-Cholest-5-ene-3,24-diol
- Product Name
- (3β,24S)-Cholest-5-ene-3,24-diol
- CAS No.
- 474-73-7
- Chemical Name
- (3β,24S)-Cholest-5-ene-3,24-diol
- Synonyms
- 24-hydroxycholesterol;24(S)-HYDROXYCHOLESTEROL;5-CHOLESTEN-3β, 24(S)-DIOL;cholest-5-ene-3β,24(S)-diol;(24S)-24-hydroxycholesterol;cholest-5-ene-3-beta,24-diol;(3β,24S)-Cholest-5-ene-3,24-diol;(3β,24S)-Cholest-5-ene-3,24-diol;Cholest-5-ene-3,24-diol, (3β,24S)-;24(S)-hydroxycholesterol (24(S)-HC)
- CBNumber
- CB6498177
- Molecular Formula
- C27H46O2
- Formula Weight
- 402.65
- MOL File
- 474-73-7.mol
(3β,24S)-Cholest-5-ene-3,24-diol Property
- Melting point:
- 174-176 °C
- Boiling point:
- 513.1±23.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
- form
- powder
- pka
- 15.03±0.70(Predicted)
- color
- white to beige
- optical activity
- [α]/D -45 to -52°, c = 1 in chloroform-d
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
N-Bromosuccinimide Price
- Product number
- SML1648
- Product name
- 24(S)-Hydroxycholesterol
- Purity
- ≥98% (HPLC)
- Packaging
- 1MG
- Price
- $124
- Updated
- 2023/06/20
- Product number
- SML1648
- Product name
- 24(S)-Hydroxycholesterol
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $504
- Updated
- 2023/06/20
- Product number
- 10009931
- Product name
- 24(S)-hydroxy Cholesterol
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 10009931
- Product name
- 24(S)-hydroxy Cholesterol
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $319
- Updated
- 2024/03/01
- Product number
- 10009931
- Product name
- 24(S)-hydroxy Cholesterol
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $601
- Updated
- 2024/03/01
(3β,24S)-Cholest-5-ene-3,24-diol Chemical Properties,Usage,Production
Description
24(S)-
Uses
(3β,24S)-Cholest-5-ene-3,24-diol is used as a biomarker in the analysis of disease.
Uses
(3β,24S)-Cholest-5-ene-3,24-diol is used as a biomarker in the analysis of disease.
Definition
ChEBI: (24S)-24-hydroxycholesterol is a 24-hydroxycholesterol that has S configuration at position 24. It is the major metabolic breakdown product of cholesterol in the brain. It has a role as a mouse metabolite, a biomarker and a human blood serum metabolite.
General Description
24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1). It is catabolized to bile acids in the liver.
Biochem/physiol Actions
24(S)-hydroxycholesterol (24HC) elevated levels are reported in liver inflammation and fibrosis. It is a N-methyl-D-aspartate receptor (NMDAR) modulator. The levels of 24HC are potential indicators of brain development as well as pathology including Alzheimer′s disease (AD) and multiple sclerosis. Polymorphism in the cholesterol 24-hydroxylase (CYP46A1) gene leads to elevated 24HC levels and toxicity. 24HC is a mediator of apoptosis and necroptosis. Elevated levels of 24HC are reported in liver inflammation and fibrosis.
References
1) Lujohann et al. (1996), Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into circulation; Proc. Natl. Acad. Sci. USA, 93 9799 2) Chawla et al. (2001), Nuclear receptors and lipid physiology:opening the X-files; Science, 294 1866 3) Kolsch et al. (1999), The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells; Brain Res., 818 171 4) Yamanaka et al. (2011), 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis; J. Biol. Chem., 286 24666 5) Wang et al. (2010), A second class of nuclear receptors for oxysterols: regulation of RORalpha and RORgamma activity by 24(S)-hydroxycholesteraol (cerebrosterol); Biochim. Biophys. Acta, 1801 917 6) Leoni and Caccia (2013), Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid; Biochem. Pharmacol., 86 26 7) Urano et al. (2013), Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking; FASEB J.,?27?4305
(3β,24S)-Cholest-5-ene-3,24-diol Preparation Products And Raw materials
Raw materials
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View Lastest Price from (3β,24S)-Cholest-5-ene-3,24-diol manufacturers
- Product
- (3β,24S)-Cholest-5-ene-3,24-diol 474-73-7
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-02