2 4-DIHYDROXY-6-METHYLBENZALDEHYDE
Uses- Product Name
- 2 4-DIHYDROXY-6-METHYLBENZALDEHYDE
- CAS No.
- 487-69-4
- Chemical Name
- 2 4-DIHYDROXY-6-METHYLBENZALDEHYDE
- Synonyms
- 133345;Orcylaldehyde;Orcylic aldehyde;2,4-Dihydroxy-6-Methylbenz;6-Methyl-β-resorcyladehyde;2,4-Dihydroxy-6-methylbenzaldehyde;Benzaldehyde, 2,4-dihydroxy-6-methyl-;2,4-Dihydroxy-6-methylbenzaldehyde - [D71751]
- CBNumber
- CB6500173
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 487-69-4.mol
2 4-DIHYDROXY-6-METHYLBENZALDEHYDE Property
- Melting point:
- 180-184 °C
- Boiling point:
- 321.9±22.0 °C(Predicted)
- Density
- 1.331±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- crystalline needles
- pka
- 7.69±0.23(Predicted)
- color
- Burnt orange
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-43
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- HS Code
- 2912490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 657603
- Product name
- 2,4-Dihydroxy-6-methylbenzaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $237
- Updated
- 2023/06/20
- Product number
- 657603
- Product name
- 2,4-Dihydroxy-6-methylbenzaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $752
- Updated
- 2023/06/20
- Product number
- D480863
- Product name
- 2,4-Dihydroxy-6-methylbenzaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2715-1-48
- Product name
- 2,4-Dihydroxy-6-methylbenzaldehyde
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- FD147432
- Product name
- 2,4-Dihydroxy-6-methylbenzaldehyde
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
2 4-DIHYDROXY-6-METHYLBENZALDEHYDE Chemical Properties,Usage,Production
Uses
2,4-Dihydroxy-6-methylbenzaldehyde is mainly used in pharmaceuticals and experimental research.
Definition
ChEBI: 2,4-dihydroxy-6-methylbenzaldehyde is a dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde in which the hydrogen at position 6 has been replaced by a methyl group. It is a fungal metabolite isolated from Grifola frondosa and Phlebiopsis gigantea. It has a role as an apoptosis inducer, an anti-inflammatory agent and a fungal metabolite.
Synthesis
504-15-4
68-12-2
487-69-4
5-Methylbenzene-1,3-diol (25.0 g, 0.2 mol) was dissolved in N,N-dimethylformamide (100 mL) at 0 °C and slowly added dropwise to a pre-cooled mixture of POCl3 (44.0 g, 0.3 mol) and N,N-dimethylformamide (200 mL). After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was slowly poured into ice water and the solid product was precipitated. The solid was collected by filtration and washed three times with distilled water to remove residual acid and solvent. Finally, the product was dried to afford 2,4-dihydroxy-6-methylbenzaldehyde (21.0 g, 82.0% yield), which could be used in subsequent reactions without further purification.
References
[1] Organic Letters, 2003, vol. 5, # 23, p. 4481 - 4484
[2] Patent: WO2004/58738, 2004, A1. Location in patent: Page 2/2; 10
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 5, p. 664 - 671
[4] Patent: WO2017/151489, 2017, A1. Location in patent: Paragraph 0284
[5] Molecules, 2018, vol. 23, # 10,
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