2-BROMO-4-NITROBENZOIC ACID

Product Name: 2-BROMO-4-NITROBENZOIC ACID
CAS No.: 16426-64-5
Chemical Name: 2-BROMO-4-NITROBENZOIC ACID
Synonyms: NSC 227965;Metoclopramide Impurity 104;3-Bromo-4-carboxynitrobenzene;BENZOIC ACID, 2-BROMO-4-NITRO;2-Bromo-4-nitrobenzoic Acid >2-Bromo-4-nitrobenzoic acid 98%
CBNumber: CB6501453
Molecular Formula: C7H4BrNO4
Formula Weight: 246.01
MOL File: 16426-64-5.mol

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2-BROMO-4-NITROBENZOIC ACID Property

Melting point:: 165-168°C
Boiling point:: 381.6±32.0 °C(Predicted)
Density: 2.0176 (rough estimate)
refractive index: 1.6200 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 1.98±0.13(Predicted)
color: Light orange to Yellow to Green
InChI: InChI=1S/C7H4BrNO4/c8-6-3-4(9(12)13)1-2-5(6)7(10)11/h1-3H,(H,10,11)
InChIKey: CEXGTXNIIFSPSF-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C([N+]([O-])=O)C=C1Br

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3607
Product name: 2-Bromo-4-nitrobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: B3607
Product name: 2-Bromo-4-nitrobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $193
Updated: 2025/07/31

TRC

Product number: B686215
Product name: 2-Bromo-4-nitrobenzoic Acid
Packaging: 5g
Price: $145
Updated: 2021/12/16

TRC

Product number: B686215
Product name: 2-Bromo-4-nitrobenzoic Acid
Packaging: 25g
Price: $380
Updated: 2021/12/16

AK Scientific

Product number: J51305
Product name: 2-Bromo-4-nitrobenzoic Acid
Packaging: 5g
Price: $25
Updated: 2021/12/16

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2-BROMO-4-NITROBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

Light Brown Solid

Synthesis

7745-93-9

16426-64-5

(a) Synthesis of 2-bromo-4-nitrobenzoic acid: 40 mL of water was added to 20 mL of pyridine solution containing 2-bromo-4-nitrotoluene (4.41 g, 20.0 mmol), and the mixture was heated to 70°C. Potassium permanganate (19.0 g, 120 mmol) was added batchwise over a 40-minute period, and the reaction mixture was subsequently refluxed for 8 hours. After completion of the reaction, the resulting suspension was thermally filtered. The filtrate was acidified with 6N hydrochloric acid to pH<2 under ice bath cooling, precipitated as a solid and filtered to give crude 2-bromo-4-nitrobenzoic acid (1.63 g). The filtrates were combined, the pH was adjusted to acidic with 6N hydrochloric acid and extracted with ethyl acetate and chloroform sequentially. The organic phases were combined, dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure to give the second batch of product (1.61 g). The total mass of the two batches of product was 3.24 g and the yield was 66%.

References

[1] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 12, p. 3011 - 3024
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 3, p. 482 - 492
[3] Angewandte Chemie - International Edition, 2008, vol. 47, # 17, p. 3184 - 3187
[4] Chinese Chemical Letters, 2011, vol. 22, # 12, p. 1411 - 1414
[5] European Journal of Medicinal Chemistry, 2014, vol. 81, p. 59 - 75

2-BROMO-4-NITROBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-4-NITROBENZOIC ACID Suppliers

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View Lastest Price from 2-BROMO-4-NITROBENZOIC ACID manufacturers

Career Henan Chemical Co

Product: 2-BROMO-4-NITROBENZOIC ACID 16426-64-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

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