ENNIATIN FROM MICROBIAL SOURCE
- Product Name
- ENNIATIN FROM MICROBIAL SOURCE
- CAS No.
- 11113-62-5
- Chemical Name
- ENNIATIN FROM MICROBIAL SOURCE
- Synonyms
- Enniatin coMplex;Enniatin microbial;ENNIATIN FROM MICROBIAL SOURCE;(3S,6R,9S,12R,15S,18R)-3,9,15-tri(butan-2-yl)-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
- CBNumber
- CB6503437
- Molecular Formula
- C36H63N3O9.C35H61N3O9.C34H59N3O9.C33H57N3O9
- Formula Weight
- 2643.46
- MOL File
- 11113-62-5.mol
ENNIATIN FROM MICROBIAL SOURCE Property
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- form
- powder
- color
- white
- LogP
- 3.048 (est)
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 22-36/37/39-45
- RIDADR
- 2811
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- 9002040
- Product name
- Enniatin Complex
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $353
- Updated
- 2024/03/01
- Product number
- 9002040
- Product name
- Enniatin Complex
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $1057
- Updated
- 2024/03/01
- Product number
- E556028
- Product name
- Enniatincomplex
- Packaging
- 5mg
- Price
- $475
- Updated
- 2021/12/16
- Product number
- E3222-30
- Product name
- Enniatin complex
- Packaging
- 10mg
- Price
- $523
- Updated
- 2021/12/16
- Product number
- E556028
- Product name
- Enniatincomplex
- Packaging
- 10mg
- Price
- $660
- Updated
- 2021/12/16
ENNIATIN FROM MICROBIAL SOURCE Chemical Properties,Usage,Production
Uses
Enniatin complex is a complex mixture of Fusarium produced depsipeptide ionophores.This compound can be used to control contamination in fermentation of gaseous substrates.
Uses
Enniatins are a complex of depsipeptides produced by several Fusarium species. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatins C, D, E and F. The enniatins act as ionophores. Recently their effects on acyl-CoA cholesterol transferase, as nematocides and the selectivity of their antitumour action have received more focus.
Biological Activity
enniatins, analogues of beauvericin, is a regular cyclic hexadepsipeptide isolated from fusarium species of fungis, also they have been isolated from other genera, such as verticillium and halosarpheia [1]. they have been involved in many biological activities, such as antiinsectan, antifungal, antibiotic and cytotoxic [1].
in vitro
fusafungine is a mixture of several enniatins with bacteriostatic activity against most micro-organisms responsible for infections and superinfections of the respiratory tract. fusafungine has been developed for treatment of upper respiratory tract infections by oral and/or nasal inhalation. fusafungine in low concentrations down-regulated the expression of intercellular adhesion molecule-1 (icam-1) by activated macrophages, inhibited the production of the proinflammatory cytokines il-1, tnfα and il-6 and inhibited the release of oxygen free radicals by inflammatory macrophages without altering their phagocytic activity. fusafungine also inhibited t-cell activation and proliferation, and the synthesis of ifn-γ by activated t cells [2]. exposure 8 h to enniatins at nanomolar concentrations significantly stimulated cell proliferation. at low micromolar concentrations, enniatins exihibited profound apoptosis-inducing effects against various human cancer cell types. in the fluorescence-activated cell sorting analysis, enniatins induced cell cycle arrest in the g0/g1 phase. in human cancer cells, elevated enn concentrations induced profound p53-dependent cytostatic and p53-independent cytotoxic activities [3]. enniatin easily incorporated into the cell membrane in which it formed cation-selective pores [4].
Purification Methods
It is a cyclic peptidic ester antibiotic which is recrystallised from EtOH/water but is deactivated in alkaline solution. [Ovchinnikov & Ivanov in The Proteins (Neurath and Hill eds) Academic Press, NY, Vol V pp. 365 and 516 1982, Tomeda et al. J Antibiot 45 1626 1992.]
References
[1] sy-cordero a a, pearce c j, oberlies n h. revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities[j]. the journal of antibiotics, 2012, 65(11): 541-549.
[2] german-fattal m. fusafungine, an antimicrobial with anti-inflammatory properties in respiratory tract infections[j]. clinical drug investigation, 2001, 21(9): 653-670.
[3] dornetshuber r, heffeter p, kamyar m r, et al. enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells[j]. chemical research in toxicology, 2007, 20(3): 465-473.
[4] kamyar m, rawnduzi p, studenik c r, et al. investigation of the electrophysiological properties of enniatins[j]. archives of biochemistry and biophysics, 2004, 429(2): 215-223.
ENNIATIN FROM MICROBIAL SOURCE Preparation Products And Raw materials
Raw materials
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