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ENNIATIN FROM MICROBIAL SOURCE

Product Name
ENNIATIN FROM MICROBIAL SOURCE
CAS No.
11113-62-5
Chemical Name
ENNIATIN FROM MICROBIAL SOURCE
Synonyms
Enniatin coMplex;Enniatin microbial;ENNIATIN FROM MICROBIAL SOURCE;(3S,6R,9S,12R,15S,18R)-3,9,15-tri(butan-2-yl)-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
CBNumber
CB6503437
Molecular Formula
C36H63N3O9.C35H61N3O9.C34H59N3O9.C33H57N3O9
Formula Weight
2643.46
MOL File
11113-62-5.mol
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ENNIATIN FROM MICROBIAL SOURCE Property

storage temp. 
2-8°C
solubility 
Soluble in DMSO
form 
powder
color 
white
LogP
3.048 (est)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
22-36/37/39-45
RIDADR 
2811
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
9002040
Product name
Enniatin Complex
Purity
≥95%
Packaging
10mg
Price
$353
Updated
2024/03/01
Cayman Chemical
Product number
9002040
Product name
Enniatin Complex
Purity
≥95%
Packaging
50mg
Price
$1057
Updated
2024/03/01
TRC
Product number
E556028
Product name
Enniatincomplex
Packaging
5mg
Price
$475
Updated
2021/12/16
Usbiological
Product number
E3222-30
Product name
Enniatin complex
Packaging
10mg
Price
$523
Updated
2021/12/16
TRC
Product number
E556028
Product name
Enniatincomplex
Packaging
10mg
Price
$660
Updated
2021/12/16
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ENNIATIN FROM MICROBIAL SOURCE Chemical Properties,Usage,Production

Uses

Enniatin complex is a complex mixture of Fusarium produced depsipeptide ionophores.This compound can be used to control contamination in fermentation of gaseous substrates.

Uses

Enniatins are a complex of depsipeptides produced by several Fusarium species. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatins C, D, E and F. The enniatins act as ionophores. Recently their effects on acyl-CoA cholesterol transferase, as nematocides and the selectivity of their antitumour action have received more focus.

Biological Activity

enniatins, analogues of beauvericin, is a regular cyclic hexadepsipeptide isolated from fusarium species of fungis, also they have been isolated from other genera, such as verticillium and halosarpheia [1]. they have been involved in many biological activities, such as antiinsectan, antifungal, antibiotic and cytotoxic [1].

in vitro

fusafungine is a mixture of several enniatins with bacteriostatic activity against most micro-organisms responsible for infections and superinfections of the respiratory tract. fusafungine has been developed for treatment of upper respiratory tract infections by oral and/or nasal inhalation. fusafungine in low concentrations down-regulated the expression of intercellular adhesion molecule-1 (icam-1) by activated macrophages, inhibited the production of the proinflammatory cytokines il-1, tnfα and il-6 and inhibited the release of oxygen free radicals by inflammatory macrophages without altering their phagocytic activity. fusafungine also inhibited t-cell activation and proliferation, and the synthesis of ifn-γ by activated t cells [2]. exposure 8 h to enniatins at nanomolar concentrations significantly stimulated cell proliferation. at low micromolar concentrations, enniatins exihibited profound apoptosis-inducing effects against various human cancer cell types. in the fluorescence-activated cell sorting analysis, enniatins induced cell cycle arrest in the g0/g1 phase. in human cancer cells, elevated enn concentrations induced profound p53-dependent cytostatic and p53-independent cytotoxic activities [3]. enniatin easily incorporated into the cell membrane in which it formed cation-selective pores [4].

Purification Methods

It is a cyclic peptidic ester antibiotic which is recrystallised from EtOH/water but is deactivated in alkaline solution. [Ovchinnikov & Ivanov in The Proteins (Neurath and Hill eds) Academic Press, NY, Vol V pp. 365 and 516 1982, Tomeda et al. J Antibiot 45 1626 1992.]

References

[1] sy-cordero a a, pearce c j, oberlies n h. revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities[j]. the journal of antibiotics, 2012, 65(11): 541-549.
[2] german-fattal m. fusafungine, an antimicrobial with anti-inflammatory properties in respiratory tract infections[j]. clinical drug investigation, 2001, 21(9): 653-670.
[3] dornetshuber r, heffeter p, kamyar m r, et al. enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells[j]. chemical research in toxicology, 2007, 20(3): 465-473.
[4] kamyar m, rawnduzi p, studenik c r, et al. investigation of the electrophysiological properties of enniatins[j]. archives of biochemistry and biophysics, 2004, 429(2): 215-223.

ENNIATIN FROM MICROBIAL SOURCE Preparation Products And Raw materials

Raw materials

Preparation Products

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ENNIATIN FROM MICROBIAL SOURCE Suppliers

11113-62-5, ENNIATIN FROM MICROBIAL SOURCERelated Search:


  • ENNIATIN FROM MICROBIAL SOURCE
  • Enniatin microbial
  • Enniatin coMplex
  • (3S,6R,9S,12R,15S,18R)-3,9,15-tri(butan-2-yl)-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
  • 11113-62-5
  • C33H57N3O9forB