OLPRINONE HYDROCHLORIDE
- Product Name
- OLPRINONE HYDROCHLORIDE
- CAS No.
- 119615-63-3
- Chemical Name
- OLPRINONE HYDROCHLORIDE
- Synonyms
- e1020;Coretec;OLPRINONE HCL;xo-,monohydrochloride,monohydrate;Olprinone hydrochloride - Loprinone hydrochloride;3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o;1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride;Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
- CBNumber
- CB6504070
- Molecular Formula
- C14H11ClN4O
- Formula Weight
- 286.72
- MOL File
- 119615-63-3.mol
OLPRINONE HYDROCHLORIDE Property
- Melting point:
- >3000C
- storage temp.
- 2-8°C
- solubility
- DMSO: ≤4 mg/mL
- form
- solid
- color
- beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O7389
- Product name
- Olprinone hydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $214
- Updated
- 2022/05/15
- Product number
- O7389
- Product name
- Olprinone hydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 50mg
- Price
- $818
- Updated
- 2022/05/15
- Product number
- 28396
- Product name
- Olprinone (hydrochloride)
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 28396
- Product name
- Olprinone (hydrochloride)
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 28396
- Product name
- Olprinone (hydrochloride)
- Packaging
- 5mg
- Price
- $122
- Updated
- 2024/03/01
OLPRINONE HYDROCHLORIDE Chemical Properties,Usage,Production
Description
Coatec was launched in Japan for acute cardiac insufficiency in cases resistant to other treatments. There are three related synthetic routes, 5-6 steps each, to loprinone all converging on 1-(imidazo[1,2a]pyridyl-6-yl)-Zpropanone as an advanced intermediate. It is a potent and selective inhibitor of PDE Ⅲ and a long lasting, orally active, positive inotropic agent. The PDE Ⅲ inhibition caused increased levels of CAMP which leads to the positive inotropic effect that was not altered by β or H2-preceptor antagonists. It was 100 times less potent at PDE I and PDE Ⅱ with no Na-K-ATPase activity. Improved hemodynamic parameters with slight changes in heart rate and blood pressure were seen in vivo. It is not mutagenic and its primary metabolite was less active.
Chemical Properties
Off-White Crystalline Powder
Originator
Eisai (Japan)
Uses
Inotropic agent which inhibits cAMP phosphodiesterase. Cardiotonic.
Definition
ChEBI: Olprinone hydrochloride is an organic molecular entity.
brand name
Coatec
OLPRINONE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from OLPRINONE HYDROCHLORIDE manufacturers
- Product
- OLPRINONE HYDROCHLORIDE 119615-63-3
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-18