ChemicalBook > CAS DataBase List > H1152, DIHYDROCHLORIDE

H1152, DIHYDROCHLORIDE

Product Name
H1152, DIHYDROCHLORIDE
CAS No.
871543-07-6
Chemical Name
H1152, DIHYDROCHLORIDE
Synonyms
H-1152 2HCl;H1152, DIHYDROCHLORIDE;H-1152 2HCl|||H-1152 dihydrochloride;H 1152 DIHYDROCHLORIDE; H1152 DIHYDROCHLORIDE;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline;(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride;H1152P2HCl,(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazineDihydrochloride;H1152P Dihydrochloride, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride
CBNumber
CB6506731
Molecular Formula
C16H21N3O2S
Formula Weight
319.42184
MOL File
871543-07-6.mol
More
Less

H1152, DIHYDROCHLORIDE Property

Melting point:
182-184°C
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Methanol, Water
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
555550
Product name
Rho Kinase Inhibitor - Calbiochem
Purity
TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific,
Packaging
1mg
Price
$324
Updated
2024/03/01
Sigma-Aldrich
Product number
555550
Product name
Rho Kinase Inhibitor - Calbiochem
Purity
TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific,
Packaging
5mg
Price
$659
Updated
2024/03/01
Tocris
Product number
2414
Product name
H1152dihydrochloride
Purity
≥98%(HPLC)
Packaging
1
Price
$231
Updated
2021/12/16
TRC
Product number
H011520
Product name
H-1152Dihydrochloride
Packaging
5mg
Price
$150
Updated
2021/12/16
Usbiological
Product number
H0004
Product name
H1152, dihydrochloride
Packaging
5mg
Price
$460
Updated
2021/12/16
More
Less

H1152, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine

Uses

ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.

Definition

ChEBI: (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride is a hydrochloride salt resulting from the reaction of (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane with 2 mol eq. of hydrogen chloride. An ATP-competitive inhibitor of Rho kinase (ROCK). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It contains a (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane(2+).

General Description

A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50 = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 μg/128 μl) solution of Rho Kinase Inhibitor (Cat. No. 555552) in H2O is also available.

Biochem/physiol Actions

Primary TargetROCK

storage

Desiccate at +4°C

H1152, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

H1152, DIHYDROCHLORIDE Suppliers

Canada 1 China 36 Germany 1 India 1 United Kingdom 2 United States 11 Global 52
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2988
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Tel
0571-85361029
Fax
0571-85361029
Email
synstar518@163.com
Country
China
ProdList
1990
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai Zeye Biotechnology Co., Ltd.
Tel
021-61998551 13122364865
Email
sale1@shzysw.net
Country
China
ProdList
9772
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4009
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15342225168
Email
yutianchun2007@126.com
Country
China
ProdList
10003
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44458
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62075
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Hubei Chuchang Chemical Co., Ltd
Tel
18; 15623560702
Email
Joy.Ren@aliyun.com
Country
China
ProdList
146
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9266
Advantage
58
Hubei Chuchang Biotech Co., Ltd.
Tel
+undefined15623860702
Email
info@chuchangbiotech.com
Country
China
ProdList
116
Advantage
58
Shanghai Xiyuan Biotechnology Co., Ltd
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6934
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Jiangxi Jianglan Pure Biological Reagent Co., Ltd.
Tel
--
Fax
--
Email
3245176082@qq.com
Country
CHINA
ProdList
6134
Advantage
58
Fujifilm Wako (Guangzhou) Trading Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
1409
Advantage
58
Shanghai Wowu Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shhebio@126.com
Country
CHINA
ProdList
6137
Advantage
58
Shanghai Machine Pure Industrial Co., Ltd.
Tel
--
Fax
--
Email
3245176082@qq.com
Country
CHINA
ProdList
6800
Advantage
58
Shanghai Ziqi Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2453006496@qq.com
Country
CHINA
ProdList
6184
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Advanced Technology & Industrial Co., Ltd.
Tel
--
Fax
--
Email
sales@advtechind.com
Country
China
ProdList
6523
Advantage
75
More
Less

View Lastest Price from H1152, DIHYDROCHLORIDE manufacturers

Hubei Chuchang Biotech Co., Ltd.
Product
H1152 871543-07-6
Price
US $0.00-0.00/MG
Min. Order
1MG
Purity
99
Supply Ability
20G
Release date
2024-07-12

871543-07-6, H1152, DIHYDROCHLORIDERelated Search:


  • 4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline
  • 5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline
  • H1152, DIHYDROCHLORIDE
  • H1152P2HCl,(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazineDihydrochloride
  • H1152P Dihydrochloride, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride
  • H-1152 2HCl
  • H 1152 DIHYDROCHLORIDE; H1152 DIHYDROCHLORIDE
  • H-1152 2HCl|||H-1152 dihydrochloride
  • (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride
  • 871543-07-6
  • C16H23Cl2N3O2S
  • Protein Kinase Inhibitors and Activators
  • Inhibitors
  • All Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals