ChemicalBook > CAS DataBase List > H1152, DIHYDROCHLORIDE

H1152, DIHYDROCHLORIDE

Product Name: H1152, DIHYDROCHLORIDE
CAS No.: 871543-07-6
Chemical Name: H1152, DIHYDROCHLORIDE
Synonyms: H-1152 2HCl;H1152, DIHYDROCHLORIDE;H-1152 2HCl|||H-1152 dihydrochloride;H-1152 dihydrochloride, 10 mM in DMSO;H 1152 DIHYDROCHLORIDE; H1152 DIHYDROCHLORIDE;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline;(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride;H1152P2HCl,(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazineDihydrochloride;H1152P Dihydrochloride, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride
CBNumber: CB6506731
Molecular Formula: C16H21N3O2S
Formula Weight: 319.42184
MOL File: 871543-07-6.mol

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H1152, DIHYDROCHLORIDE Property

Melting point:: 182-184°C
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Methanol, Water
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 555550
Product name: Rho Kinase Inhibitor - Calbiochem
Purity: TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific,
Packaging: 1mg
Price: $337
Updated: 2025/07/31

Sigma-Aldrich

Product number: 555550
Product name: Rho Kinase Inhibitor - Calbiochem
Purity: TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific,
Packaging: 5mg
Price: $685
Updated: 2025/07/31

Tocris

Product number: 2414
Product name: H1152dihydrochloride
Purity: ≥98%(HPLC)
Packaging: 1
Price: $231
Updated: 2021/12/16

TRC

Product number: H011520
Product name: H-1152Dihydrochloride
Packaging: 5mg
Price: $150
Updated: 2021/12/16

TRC

Product number: H011520
Product name: H-1152Dihydrochloride
Packaging: 25mg
Price: $695
Updated: 2021/12/16

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H1152, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine

Uses

ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.

Definition

ChEBI: (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride is a hydrochloride salt resulting from the reaction of (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane with 2 mol eq. of hydrogen chloride. An ATP-competitive inhibitor of Rho kinase (ROCK). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It contains a (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane(2+).

General Description

A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; K_i = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (K_i = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC₅₀ = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 μg/128 μl) solution of Rho Kinase Inhibitor (Cat. No. 555552) in H₂O is also available.

Biochem/physiol Actions

Primary TargetROCK

storage

Desiccate at +4°C

H1152, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from H1152, DIHYDROCHLORIDE manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: H1152 871543-07-6
Price: US $0.00-0.00/MG
Min. Order: 1MG
Purity: 99
Supply Ability: 20G
Release date: 2024-07-12

871543-07-6, H1152, DIHYDROCHLORIDERelated Search:

4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline

5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline

H1152, DIHYDROCHLORIDE

H1152P2HCl,(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazineDihydrochloride

H1152P Dihydrochloride, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride

H-1152 2HCl

H 1152 DIHYDROCHLORIDE; H1152 DIHYDROCHLORIDE

H-1152 2HCl|||H-1152 dihydrochloride

(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride

H-1152 dihydrochloride, 10 mM in DMSO

871543-07-6

C16H23Cl2N3O2S

Protein Kinase Inhibitors and Activators

Inhibitors

All Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals