H1152, DIHYDROCHLORIDE
- Product Name
- H1152, DIHYDROCHLORIDE
- CAS No.
- 871543-07-6
- Chemical Name
- H1152, DIHYDROCHLORIDE
- Synonyms
- H-1152 2HCl;H1152, DIHYDROCHLORIDE;H-1152 2HCl|||H-1152 dihydrochloride;H 1152 DIHYDROCHLORIDE; H1152 DIHYDROCHLORIDE;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline;(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride;H1152P2HCl,(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazineDihydrochloride;H1152P Dihydrochloride, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride
- CBNumber
- CB6506731
- Molecular Formula
- C16H21N3O2S
- Formula Weight
- 319.42184
- MOL File
- 871543-07-6.mol
H1152, DIHYDROCHLORIDE Property
- Melting point:
- 182-184°C
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- Methanol, Water
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- 555550
- Product name
- Rho Kinase Inhibitor - Calbiochem
- Purity
- TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific,
- Packaging
- 1mg
- Price
- $324
- Updated
- 2024/03/01
- Product number
- 555550
- Product name
- Rho Kinase Inhibitor - Calbiochem
- Purity
- TheRhokinaseinhibitor,CAS872543-07-6,isacell-permeable,highlyspecific,
- Packaging
- 5mg
- Price
- $659
- Updated
- 2024/03/01
- Product number
- 2414
- Product name
- H1152dihydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 1
- Price
- $231
- Updated
- 2021/12/16
- Product number
- H011520
- Product name
- H-1152Dihydrochloride
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- H011520
- Product name
- H-1152Dihydrochloride
- Packaging
- 25mg
- Price
- $695
- Updated
- 2021/12/16
H1152, DIHYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine
Uses
ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.
Definition
ChEBI: (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride is a hydrochloride salt resulting from the reaction of (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane with 2 mol eq. of hydrogen chloride. An ATP-competitive inhibitor of Rho kinase (ROCK). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It contains a (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane(2+).
General Description
A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50 = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 μg/128 μl) solution of Rho Kinase Inhibitor (Cat. No. 555552) in H2O is also available.
Biochem/physiol Actions
Primary TargetROCK
storage
Desiccate at +4°C
H1152, DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
H1152, DIHYDROCHLORIDE Suppliers
View Lastest Price from H1152, DIHYDROCHLORIDE manufacturers
- Product
- H1152 871543-07-6
- Price
- US $0.00-0.00/MG
- Min. Order
- 1MG
- Purity
- 99
- Supply Ability
- 20G
- Release date
- 2024-07-12