CDK12 antibody
Source Reactivity Background References- Product Name
- CDK12 antibody
- Chemical Name
- CDK12 antibody
- Synonyms
- CDK12 antibody;Rabbit Polyclonal CDK12 Antibody
- CBNumber
- CB65616415
- Formula Weight
- 0
- MOL File
- Mol file
CDK12 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Monkey
Background
Cyclin-dependent kinase 12 is composed of a central CTD kinase domain, several proline-rich regions, and several amino-terminal arginine/serine motifs common to splicing factors. CDK12 is ubiquitously expressed and forms a complex with cyclin K that regulates phosphorylation of the C-terminal domain of RNA polymerase II. CDK12 is important for expression of a subset of long genes with high numbers of exons including some regulators of the DNA damage response, such as breast and ovarian cancer type 1 susceptibility protein 1 and ataxia telangiectasia and Rad3-related. Depletion of CDK12 results in spontaneous DNA damage and increased sensitivity to DNA damage agents. Research studies have shown that CDK12 is recurrently mutated in high-grade ovarian cancer. In addition, high levels of CDK12 are required to maintain pluripotency of embryonic stem cells.
References
[1] Ko, T.K. et al. (2001) J Cell Sci 114, 2591-603.
[2] Bartkowiak, B. et al. (2010) Genes Dev 24, 2303-16.
[3] Blazek, D. et al. (2011) Genes Dev 25, 2158-72.
[4] Cheng, S.W. et al. (2012) Mol Cell Biol 32, 4691-704.
[5] The Cancer Genome Atlas Research Network (2011) Nature 474, 609-15.
[6] Carter, S.L. et al. (2012) Nat Biotechnol 30, 413-21.
[7] Dai, Q. et al. (2012) J Biol Chem 287, 25344-52.
CDK12 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
CDK12 antibody Suppliers
- Tel
- 15921930842 15921930842
- yh-wang@univ-bio.com
- Country
- China
- ProdList
- 25004
- Advantage
- 58
- Tel
- 18007124176 19384116026
- 2706668885@qq.com
- Country
- China
- ProdList
- 4987
- Advantage
- 58
- Tel
- 027-87196173
- cusabio@163.com
- Country
- China
- ProdList
- 6066
- Advantage
- 58
- Tel
- 027-19371278702 18008634902
- nuodina88@163.com
- Country
- China
- ProdList
- 3011
- Advantage
- 58
- Tel
- 858.663.9055 8586639055
- NSJBioname@qq.com
- Country
- China
- ProdList
- 6941
- Advantage
- 58
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
- 6174
- Advantage
- 58
- Tel
- 21-80243558 86218024
- info@cellsignal.cn
- Country
- China
- ProdList
- 6725
- Advantage
- 58
- Tel
- 4006-123-828 13162017139
- market@ab-mart.com
- Country
- China
- ProdList
- 6917
- Advantage
- 58
- Tel
- 0512-65829739
- antibodies-onlinename@qq.com
- Country
- China
- ProdList
- 0
- Advantage
- 58
- Tel
- 15121098156
- Country
- CHINA
- ProdList
- 134
- Advantage
- 58