Homo-PROTAC pVHL30 degrader 1

Product Name: Homo-PROTAC pVHL30 degrader 1
CAS No.: 2244684-49-7
Chemical Name: Homo-PROTAC pVHL30 degrader 1
Synonyms: CM11 VHL inhibitor;CM11 (Homo-PROTAC);Homo-PROTAC pVHL30 degrader 1;Homo-PROTAC pVHL30 degrader 1, 10 mM in DMSO;PROTACs,Inhibitor,Homo PROTAC pVHL30 degrader 1,Homo-PROTAC pVHL-30 degrader 1,Homo-PROTAC pVHL30 degrader 1,HomoPROTAC pVHL30 degrader 1,inhibit;N1,N20-Bis((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosane-1,20-diamide;N,N'-bis[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]-3,6,9,12,15,18-hexaoxaicosanediamide
CBNumber: CB65848810
Molecular Formula: C58H82N8O14S2
Formula Weight: 1179.46
MOL File: 2244684-49-7.mol

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Homo-PROTAC pVHL30 degrader 1 Property

Boiling point:: 1293.3±65.0 °C(Predicted)
Density: 1.266±0.06 g/cm3(Predicted)
storage temp.: 4°C, stored under nitrogen
solubility: DMSO : ≥ 150 mg/mL (127.18 mM)
pka: 13.24±0.46(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC11590
Product name: CM-11
Purity: >98%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

DC Chemicals

Product number: DC11590
Product name: CM-11
Purity: >98%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC11590
Product name: CM-11
Purity: >98%
Packaging: 1g
Price: $2900
Updated: 2021/12/16

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Homo-PROTAC pVHL30 degrader 1 Chemical Properties,Usage,Production

Uses

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.

IC 50

VHL

storage

Store at -20°C

References

[1] Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830. DOI:10.1038/s41467-017-00954-1

Homo-PROTAC pVHL30 degrader 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Homo-PROTAC pVHL30 degrader 1 Suppliers

China 28 United States 4 Global 32

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2244684-49-7, Homo-PROTAC pVHL30 degrader 1Related Search:

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N,N'-bis[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]-3,6,9,12,15,18-hexaoxaicosanediamide

Homo-PROTAC pVHL30 degrader 1, 10 mM in DMSO

N1,N20-Bis((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosane-1,20-diamide

2244684-49-7

C58H82N8O14S2