DOTA di(tBu)ester

Product Name: DOTA di(tBu)ester
CAS No.: 913542-71-9
Chemical Name: DOTA di(tBu)ester
Synonyms: DOTA di(tBu)ester;Zaterol impurity 3;Gadobutrol Impurity 91;Gadobutrol Impurity 243;DOTA-bis(tert-butyl)ester;1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,7-bis(1,1-dimethylethyl) ester;2,2'-(4,10-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid;1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate or DOTA-bis(tert-butyl)ester
CBNumber: CB65857245
Molecular Formula: C24H44N4O8
Formula Weight: 516.63
MOL File: 913542-71-9.mol

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DOTA di(tBu)ester Property

Boiling point:: 644.7±55.0 °C(Predicted)
Density: 1.133±0.06 g/cm3(Predicted)
pka: 3.94±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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DOTA di(tBu)ester Chemical Properties,Usage,Production

Uses

DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.

IC 50

RDC Bifunctional Chelator

DOTA di(tBu)ester Preparation Products And Raw materials

Raw materials

Preparation Products

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DOTA di(tBu)ester Suppliers

China 32 Global 32

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913542-71-9, DOTA di(tBu)esterRelated Search:

DOTA di(tBu)ester

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,7-bis(1,1-dimethylethyl) ester

2,2'-(4,10-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid

Zaterol impurity 3

1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate

Gadobutrol Impurity 91

DOTA-bis(tert-butyl)ester

1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate or DOTA-bis(tert-butyl)ester

Gadobutrol Impurity 243

913542-71-9