Boc-Val-Ala-PAB-PNP
Uses In vitro Storage- Product Name
- Boc-Val-Ala-PAB-PNP
- CAS No.
- 1884578-00-0
- Chemical Name
- Boc-Val-Ala-PAB-PNP
- Synonyms
- Boc-Val-Ala-PAB-PNP;Boc-Val-Ala-PAB-PNP USP/EP/BP;4-[(S)-2-[(S)-2-(Boc-amino)-3-methylbutanamido]propanamido]benzyl (4-Nitrophenyl) Carbonate;L-Alaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;tert-Butyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate
- CBNumber
- CB65864429
- Molecular Formula
- C27H34N4O9
- Formula Weight
- 558.58
- MOL File
- 1884578-00-0.mol
Boc-Val-Ala-PAB-PNP Property
- Boiling point:
- 793.1±60.0 °C(Predicted)
- Density
- 1.269±0.06 g/cm3(Predicted)
- pka
- 11.26±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- ADC1050
- Product name
- Boc-Val-Ala-PAB-PNP
- Packaging
- 100mg
- Price
- $168.75
- Updated
- 2021/12/16
- Product number
- ADC1050
- Product name
- Boc-Val-Ala-PAB-PNP
- Packaging
- 250mg
- Price
- $337.5
- Updated
- 2021/12/16
- Product number
- ADC1050
- Product name
- Boc-Val-Ala-PAB-PNP
- Packaging
- 1g
- Price
- $1012.5
- Updated
- 2021/12/16
Boc-Val-Ala-PAB-PNP Chemical Properties,Usage,Production
Uses
Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Description
Boc-Val-Ala-PAB-PNP can be used to design cleavable ADC linkers. The Val-Ala, as shown in the ACD Zynlonta, is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Boc-Val-Ala-PAB-PNP Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Boc-Val-Ala-PAB-PNP manufacturers
- Product
- Boc-Val-Ala-PAB-PNP 1884578-00-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >95.00%
- Supply Ability
- 1g
- Release date
- 2024-03-29