SR12343

Product Name: SR12343
CAS No.: 2055101-86-3
Chemical Name: SR12343
Synonyms: SR12343;N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide;Acetamide, N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-
CBNumber: CB65867455
Molecular Formula: C15H15BrClN3O
Formula Weight: 368.66
MOL File: 2055101-86-3.mol

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SR12343 Property

Boiling point:: 603.4±55.0 °C(Predicted)
Density: 1.496±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
form: A crystalline solid
pka: 14.86±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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SR12343 Chemical Properties,Usage,Production

Biological Activity

SR 12343 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It selectively disrupts the association of NEMO/IKKγ with IKKβ over TNF receptor-associated factor 2 (TRAF2), IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at concentrations ranging from 25 to 150 μM. SR 12343 inhibits TNF-α-induced NF-κB activation in a reporter assay. It reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia when administered at a dose of 10 mg/kg. SR 12343 (30 mg/kg) improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy.

References

1.Zhao, J., Zhang, L., Mu, X., et al.Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activationPLoS Biol.16(6)e2004663(2018)

SR12343 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR12343 Suppliers

China 9 United States 2 Global 11

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2055101-86-3, SR12343Related Search:

SR12343

Acetamide, N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-

N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide

2055101-86-3

C15H15BrClN3O