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SR12343

Product Name
SR12343
CAS No.
2055101-86-3
Chemical Name
SR12343
Synonyms
SR12343;N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide;Acetamide, N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-
CBNumber
CB65867455
Molecular Formula
C15H15BrClN3O
Formula Weight
368.66
MOL File
2055101-86-3.mol
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SR12343 Property

Boiling point:
603.4±55.0 °C(Predicted)
Density 
1.496±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
form 
A crystalline solid
pka
14.86±0.46(Predicted)
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Hazard and Precautionary Statements (GHS)

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SR12343 Chemical Properties,Usage,Production

Biological Activity

SR 12343 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It selectively disrupts the association of NEMO/IKKγ with IKKβ over TNF receptor-associated factor 2 (TRAF2), IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at concentrations ranging from 25 to 150 μM. SR 12343 inhibits TNF-α-induced NF-κB activation in a reporter assay. It reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia when administered at a dose of 10 mg/kg. SR 12343 (30 mg/kg) improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy.

References

1.Zhao, J., Zhang, L., Mu, X., et al.Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activationPLoS Biol.16(6)e2004663(2018)

SR12343 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR12343 Suppliers

Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136
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21-5161 9052
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info@SuperLan-chem.com
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China
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InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
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United States
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Jinan Jiuli Biotechnology Co. , Ltd.
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2717893647 14768611851
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486064515@qq.com
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China
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ChemeGen 中国
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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6975
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InvivoChem
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13549236410
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sales@invivochem.cn
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China
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6749
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Beijing Biocreative Technology Co., Ltd.
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15522676233
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3007606172@qq.com
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China
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Nanjing Tengyi Biotechnology Co., Ltd
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025-58851786 17714337195
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sales@tybiochem.com
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China
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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025-85563444
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cindy.huang@synzest.com
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China
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YJ Pharma
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0513-15251351988 15251351988
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3686954964@qq.com
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China
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372
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2055101-86-3, SR12343Related Search:


  • SR12343
  • Acetamide, N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-
  • N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide
  • 2055101-86-3
  • C15H15BrClN3O