ChemicalBook > CAS DataBase List > TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE

TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE

Product Name
TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE
CAS No.
864771-44-8
Chemical Name
TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE
Synonyms
2-(1-Bo;1-Boc-indazole-5-boronic acid pinacol ester;1-Boc-indazolyl-5-boronic Acid Pinacol Ester;1-Boc-1H-indalzole-5-boronic acid picol ester;1-Boc-1H-indalzole-5-boronic acid pinacol ester;1H-Indazole-5-boronic acid pinacol ester, N1-BOC protected;1-(tert-Butoxycarbonyl)indazolyl-5-boronic Acid Pinacol Ester;1-Boc-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole;1-(tert-Butoxycarbonyl)-1H-indazole-5-boronic acid pinacol ester;1-Boc-5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
CBNumber
CB6589574
Molecular Formula
C18H25BN2O4
Formula Weight
344.21
MOL File
864771-44-8.mol
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TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE Property

Melting point:
110 °C
Boiling point:
461.4±37.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.48±0.30(Predicted)
form 
solid
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-26-36/37/39
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CVT00055
Product name
1-Boc-5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole, contains isomer
Packaging
1g
Price
$356
Updated
2025/07/31
TCI Chemical
Product number
B5992
Product name
1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole
Purity
min. 98.0 %
Packaging
200MG
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
B5992
Product name
1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole
Purity
min. 98.0 %
Packaging
1G
Price
$159
Updated
2025/07/31
TRC
Product number
B682943
Product name
1-Boc-indazole-5-boronicacid,pinacolester
Packaging
50mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
409023
Product name
1-Boc-indazole-5-boronic acid, pinacol ester
Packaging
25mg
Price
$305
Updated
2021/12/16
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TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

651780-02-8

73183-34-3

864771-44-8

Tert-butyl 5-bromo-1H-indazole-1-carboxylate (10.1 mmol) and pinacol ester of bisboronic acid (11.1 mmol) were used as raw materials for the reaction catalyzed by palladium(II) acetate (1.01 mmol) and dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) (1.01 mmol) with the addition of potassium acetate (30.3 mmol) in triethylamine ( 1.5 mL) solution of potassium acetate (30.3 mmol) and 1,4-dioxane (60 mL) as a solvent, and the reaction was carried out at 110 °C overnight. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by fast column chromatography (eluent: 5% ethyl acetate/petroleum ether) to afford the target product 1-tert-butoxycarbonylindazole-5-boronic acid pinacol ester as a yellow solid in 74% yield.

References

[1] Patent: WO2011/66211, 2011, A1. Location in patent: Page/Page column 69-70
[2] Organic Letters, 2009, vol. 11, # 13, p. 2860 - 2863
[3] Patent: WO2010/59943, 2010, A2. Location in patent: Page/Page column 83; 84
[4] Patent: WO2006/86705, 2006, A1. Location in patent: Page/Page column 89
[5] Patent: US2008/153813, 2008, A1. Location in patent: Page/Page column 22

TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE Suppliers

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View Lastest Price from TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE manufacturers

Career Henan Chemical Co
Product
TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE 864771-44-8
Price
US $6.60/KG
Min. Order
500g
Purity
98%
Supply Ability
1KG, 50KG, 100KG
Release date
2019-12-25

864771-44-8, TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATERelated Search:

TERT-BUTYL FORMATE INDAZOLE-5-BORONIC ACID PINACOL ESTER 1H-INDAZOLE-5-BORONIC ACID 1-METHYLINDAZOL-5-BORONIC ACID TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDAZOLE-1-CARBOXYLATE

  • 1-(tert-Butoxycarbonyl)-1H-indazole-5-boronic acid pinacol ester
  • 1-Boc-indazole-5-boronic acid pinacol ester
  • tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate
  • 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)- indazole-1-carboxylic acid tert-butyl ester
  • tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate, 1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
  • 1H-Indazole-1-carboxylicacid,5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-,1,1-diMethylethylester
  • tert-butyl 5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate
  • 1-Boc-5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
  • 1-Boc-1H-indalzole-5-boronic acid pinacol ester
  • 1-Boc-5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole, contains isomer
  • tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate
  • tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole-1-carboxyla
  • 1H-Indazole-5-boronic acid pinacol ester, N1-BOC protected
  • 1-Boc-1H-indalzole-5-boronic acid picol ester
  • 1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole
  • 1-(tert-Butoxycarbonyl)indazolyl-5-boronic Acid Pinacol Ester
  • 1-Boc-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)indazole
  • 1-Boc-indazolyl-5-boronic Acid Pinacol Ester
  • 2-(1-Bo
  • 2-(1-tert-Butoxycarbonyl-5-indazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole-1-carboxylate
  • tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-1-carboxylate
  • tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)indazole-1-carboxylate
  • tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate - [B13702]
  • 864771-44-8
  • C18H25BN2O4
  • Indazoles