5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE

Product Name: 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE
CAS No.: 51516-70-2
Chemical Name: 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE
Synonyms: AKOS B029474;BUTTPARK 51\09-64;TIMTEC-BB SBB000407;5-Amino-1-(4-fluorophenyl);5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole97%;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole 97%;5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE;1H-Pyrazole-4-carbonitrile, 5-amino-1-(4-fluorophenyl)-
CBNumber: CB6663838
Molecular Formula: C10H7FN4
Formula Weight: 202.19
MOL File: 51516-70-2.mol

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5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Property

Melting point:: 164-165°C
Boiling point:: 394.1±37.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: -0.92±0.10(Predicted)
form: solid
Appearance: Yellow to brown Solid
CAS DataBase Reference: 51516-70-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-41
Safety Statements: 22-36/37/39-39-26
RIDADR: 3439
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0041
Product name: 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile
Purity: Aldrich
Packaging: 1g
Price: $107
Updated: 2025/07/31

TRC

Product number: A602185
Product name: 5-Amino-1-(4-fluorophenyl)pyrazole-4-carbonitrile
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA54002
Product name: 5-Amino-4-cyano-1-(4-fluorophenyl)pyrazole
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA54002
Product name: 5-Amino-4-cyano-1-(4-fluorophenyl)pyrazole
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA54002
Product name: 5-Amino-4-cyano-1-(4-fluorophenyl)pyrazole
Packaging: 1g
Price: $160
Updated: 2021/12/16

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5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Chemical Properties,Usage,Production

Uses

5-Amino-1-(4-fluorophenyl)pyrazole-4-carbonitrile was used in the preparation of compounds that were shown to have anti-viral activity against TMV.

Synthesis

371-14-2

123-06-8

51516-70-2

GENERAL METHOD: (4-Fluorophenyl)hydrazine (0.001 mol) was mixed with 10 mL of ethanol, stirred and heated to reflux. Subsequently, ethoxymethylene malononitrile (0.001 mol) dissolved in 10 mL of ethanol was added slowly and dropwise. The reaction mixture was kept at reflux for 2 hours. After completion of the reaction, the mixture was poured into 50 mL of ice water. The precipitate was collected by filtration and washed with cold water to afford 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile (10a) in 61% yield. The product characterization data were as follows: melting point: 173-174 °C. IR (cm^-1): 3297-3183 (NH2); 2225 (CN); 1662; 1568. ^1H NMR (400 MHz, DMSO-d6, TMS, δ in ppm): 7.31-7.25 (m, 2H, H3', H5'); 7.54- 7.49 (m, 2H, H2', H6'); 7.67 (s, 1H, H3). ^13C NMR (100 MHz, DMSO-d6, TMS, δ in ppm): 73.2 (C4); 114.8 (CN); 116.3 (d, J = 22.8 Hz, C3', C5'); 126.9 (d, J = 8.9 Hz, C2', C6'); 133.7 (d, J = 2.8 Hz, C1'); 141.7 (C5); 151.4 (C3); 161.2 (d, J = 243.6 Hz, C4'). ^19F NMR (376 MHz, DMSO-d6, TMS, δ in ppm): -114.26. EI-MS [M + 1]^+: 203.07.

References

[1] European Journal of Organic Chemistry, 2018, vol. 2018, # 13, p. 1514 - 1524
[2] Tetrahedron Letters, 2008, vol. 49, # 2, p. 305 - 310
[3] Medicinal Chemistry Research, 2018, vol. 27, # 8, p. 1876 - 1884
[4] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2892 - 2898
[5] Organic and Biomolecular Chemistry, 2007, vol. 5, # 17, p. 2758 - 2761

5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE Suppliers

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51516-70-2, 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLERelated Search:

5-AMINO-1-(4,6-DIFLUOROPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE 5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-4-CYANOPYRAZOLE 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE 5-AMINO-1-(4-FLUOROPHENYL)-3-METHYL-1H-PYRAZOLE-4-CARBONITRILE 5-amino-3-(4-fluorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile AKOS BBS-00002128 5-amino-3-(2,4-dichlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 5-amino-1-(3-chloro-4-fluorophenyl)-3-cyclobutyl-1H-pyrazole-4-carbonitrile BINUCLEINE 2 5-AMINO-3-CYANOMETHYL-1-(4-FLUORO-PHENYL)-1H-PYRAZOLE-4-CARBONITRILE BUTTPARK 34\09-23 5-amino-1-(3-chloro-4-fluorophenyl)-3-cyclopentyl-1H-pyrazole-4-carbonitrile 5-amino-3-(2-fluorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 5-amino-3-(2-chloro-4-methylphenyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 5-amino-3-[4-(trifluoromethyl)phenyl]-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 5-amino-3-cyclobutyl-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 5-amino-3-[3-(trifluoromethyl)phenyl]-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 5-amino-3-(3-fluorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile

TIMTEC-BB SBB000407

BUTTPARK 51\09-64

AKOS B029474

5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE

5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE

5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole 97%

5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole97%

5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 97%

5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile97%

5-Amino-1-(4-fluorophenyl)

5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole

1H-Pyrazole-4-carbonitrile, 5-amino-1-(4-fluorophenyl)-

51516-70-2

C10H7FN4