4-METHYL-1-INDANONE
- Product Name
- 4-METHYL-1-INDANONE
- CAS No.
- 24644-78-8
- Chemical Name
- 4-METHYL-1-INDANONE
- Synonyms
- 4-METHYL-INDANONE;4-METHYL-1-INDANONE;4-Methyl-indan-1-one;4-Methyl-1-indanone 97%;4-Methyl-1-indanone, 99+%;4-methyl-2,3-dihydroinden-1-one;2,3-dihydro-4-methylinden-1-one;2,3-dihydro-4-methyl-1H-Inden-1-one;1H-Inden-1-one, 2,3-dihydro-4-Methyl-
- CBNumber
- CB6664219
- Molecular Formula
- C10H10O
- Formula Weight
- 146.19
- MOL File
- 24644-78-8.mol
4-METHYL-1-INDANONE Property
- Melting point:
- 94-96 °C (lit.)
- Boiling point:
- 205.81°C (rough estimate)
- Density
- 0.9071 (rough estimate)
- refractive index
- 1.5530 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- color
- White to yellow
- InChI
- InChI=1S/C10H10O/c1-7-3-2-4-9-8(7)5-6-10(9)11/h2-4H,5-6H2,1H3
- InChIKey
- RUORWXQKVXTQJJ-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C(C)=CC=C2)CC1
- CAS DataBase Reference
- 24644-78-8(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29143990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 433047
- Product name
- 4-Methyl-1-indanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $154
- Updated
- 2023/06/20
- Product number
- 433047
- Product name
- 4-Methyl-1-indanone
- Purity
- 97%
- Packaging
- 5g
- Price
- $287
- Updated
- 2022/05/15
- Product number
- M227265
- Product name
- 4-Methyl-2,3-dihydro-1H-inden-1-one
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- M227265
- Product name
- 4-Methyl-2,3-dihydro-1H-inden-1-one
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- Z4489
- Product name
- 4-Methyl-2,3-dihydro-1H-inden-1-one
- Packaging
- 25g
- Price
- $717
- Updated
- 2021/12/16
4-METHYL-1-INDANONE Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Methyl-2,3-dihydro-1H-inden-1-one acts as a reagent in the synthesis of the following organic compounds: 3,6-dimethylcholanthrene, 3,6-dimethyl-7-methoxycholanthrene and 3-methyl-7-methoxycholanthrene.
Uses
4-Methyl-1-indanone may be used for the following syntheses:
- 3,6-dimethylcholanthrene
- 3,6-dimethyl-7-methoxycholanthrene
- 3-methyl-7-methoxycholanthrene
- methyl 4-methyl-1-fluoroindan-1-carboxylate (4-Me-FICA Me ester)
General Description
4-Methyl-1-indanone on condensation with 2-lithio-N,N-diethyl-1-napthamide and 2-lithio-N,N-diethyl-8-methoxy-1-napthamide, followed by hydrolysis afforded 2-(1-hydroxy-4-methylindan-1-yl)-1-naphthoic acid lactone and 2-(1-hydroxy-4-methylindan-1-yl)-8-methoxy-1-naphthoic acid lactone respectively.
Synthesis
22084-89-5
24644-78-8
General procedure for the synthesis of 4-methyl-2,3-dihydro-1H-inden-1-one from 3-(2-methylphenyl)propionic acid: trifluoromethanesulfonic acid (3 equiv.) was slowly added to a solution of 3-(2-methylphenyl)propionic acid (0.5 mmol) dissolved in anhydrous dichloromethane (1.0 mL) in a 12 mL Q-tube?pressure tube at 0 °C (provided by QLabtech). The reaction system was then warmed to room temperature. A PTFE septum was placed on top of the reaction tube and sealed using the appropriate cap and pressure adapter. The sealed reaction tube was heated in an oil bath at 80°C. The progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC/MS) until the feedstock was completely consumed. Upon completion of the reaction, the mixture was poured into ice water and extracted three times with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Finally, the target compound 4-methyl-2,3-dihydro-1H-inden-1-one was purified from the crude product by fast column chromatography.
References
[1] Molecules, 2014, vol. 19, # 5, p. 5599 - 5610
[2] Patent: WO2013/74892, 2013, A1. Location in patent: Page/Page column 39-40
[3] Patent: US9125407, 2015, B2. Location in patent: Page/Page column 27; 28
[4] Chemistry - A European Journal, 2017, vol. 23, # 53, p. 13037 - 13041
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 1994, vol. 91, # 1-4, p. 69 - 80
4-METHYL-1-INDANONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-METHYL-1-INDANONE manufacturers
- Product
- 4-METHYL-1-INDANONE 24644-78-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2018-08-17