ALMITRINE

Product Name: ALMITRINE
CAS No.: 27469-53-0
Chemical Name: ALMITRINE
Synonyms: S-2620;ALMITRINE;AlMitrine Mesylate;ALMITRINE USP/EP/BP;Almitrine dimethanesulfonic acid;2,4-Bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine;1-[2,4-Bis(allylamino)-1,3,5-triazin-6-yl]-4-[bis(4-fluorophenyl)methyl]piperazine;6-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]-N,N'-di(2-propenyl)-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N2,N4-di-2-propen-1-yl-
CBNumber: CB6667472
Molecular Formula: C26H29F2N7
Formula Weight: 477.55
MOL File: 27469-53-0.mol

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ALMITRINE Property

Melting point:: 181°
Density: 1.2278 (estimate)
form: Solid

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Safety

Toxicity: LD50 ipr-mus: 390 mg/kg DRFUD4 3,717,78

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0009191
Product name: ALMITRINE
Purity: 95.00%
Packaging: 25MG
Price: $225.75
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 18470
Product name: Almitrine
Packaging: 5mg
Price: $950
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 18470
Product name: Almitrine
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

AvaChem

Product number: 1592B
Product name: Almitrine
Packaging: 1g
Price: $890
Updated: 2021/12/16

AvaChem

Product number: 1592B
Product name: Almitrine
Packaging: 10mg
Price: $49
Updated: 2021/12/16

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ALMITRINE Chemical Properties,Usage,Production

Originator

Armanor ,Les Laboratoires Servier

Uses

Respiratory stimulant.

Definition

ChEBI: A triamino-1,3,5-triazine compound having allylamino substituents at the 2- and 4-positions and a 4-(bis(p-fluorophenyl)methyl)-1-piperazinyl group at the 6-position.

Manufacturing Process

A solution of 4,6-bis(allylamino)-2-chloro-s-triazine, melting point 204°C (Kofler) and dihydrochloride of 1-p,p'-difluorobenzhydryl piperazine, melting point 178°-180°C (capillary) in anhydrous dimethylformamide are heated under reflux. On completion of this operation the solvent is removed under vacuum and the residue taken up in a mixture of chloroform and of water (1:1). The organic phase is separated, and repeatedly extracted with aqueous N-methanesulphonic acid and the aqueous acidic layers separated. The aforementioned acidic solutions are then combined and rendered alkaline (pH 10) with dilute aqueous sodium hydroxide, the base extracted with ether, the extract dried over anhydrous potassium carbonate, and filtered. The etheral filtrate, upon evaporation yields the 2,4-bis(allylamino)-6-(4-(bis(pfluorophenyl) methyl)-1-piperazinyl)-s-triazine, melting point 175°-180°C.

brand name

Vectarion (Oril S.A., France).

Therapeutic Function

Respiratory stimulant

World Health Organization (WHO)

Peripheral neuropathy has been reported in a few patients receiving almitrine for long periods. The indications for treatment have consequently been restricted in the Federal Republic of Germany. Some other countries have advised doctors to maintain patients under close supervision throughout treatment and to restrict dosage to two out of every three months.

Pharmacology

Almitrine, like doxapram, increases the rate and depth of respiration. In addition, it is believed that it redistributes pulmonary blood circulation, increasing it in alveoli, which leads to relatively better pulmonary ventilation. It has a more prolonged effect than doxapram.

Safety Profile

Poison by intraperitoneal andintravenous routes. When heated to decomposition itemits very toxic fumes of F?? and NOx.

Synthesis

Almitrine, 2,4-bis (allylamino)-6-[4-[bis-(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine (8.2.6), is synthesized by reacting 1-[bis-(p-fluorophenyl)methyl]piperazine with cyanuric chloride, which gives 2,4-dichloro-6-[4-[bis-(p-fluorophenyl) methyl]-1-piperazinyl]-s-trazine (8.2.5). Reacting this with allylamine gives almitrine (8.2.6) [19¨C22].

ALMITRINE Preparation Products And Raw materials

Raw materials

Preparation Products

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ALMITRINE Suppliers

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View Lastest Price from ALMITRINE manufacturers

Hebei Duling International Trade Co. LTD

Product: ALMITRINE 27469-53-0
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 tons
Release date: 2023-02-23

Dideu Industries Group Limited

Product: ALMITRINE 27469-53-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-27

Career Henan Chemical Co

Product: almitrine 27469-53-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: G/KG/TON
Release date: 2020-01-31

27469-53-0, ALMITRINERelated Search:

TRIAZINONE almitrine-raubasine TRIETAZINE-ETHYLAMINO Melamine hydrogen flouride 4,4'-Difluorobenzhydrylpiperazine 1-(4-FLUORO-ALPHA-PHENYLBENZYL)PIPERAZINE (R)-1-(4-Fluorophenyl)ethylamine 1-(1,3,5-TRIAZIN-2-YL)PIPERAZINE (S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE ALMITRINE BISMESYLATE,ALMITRINE DIMESYLATE,ALMITRINE DIMESILATE 1-(4-FLUOROBENZYL)PIPERAZINE (R)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE 1-[1-(4-FLUORO-PHENYL)-ETHYL]-PIPERAZINE ALMITRINE (S)-1-(4-FLUOROPHENYL)ETHYLAMINE (4-fluorophenyl)(phenyl)methylamine

ALMITRINE

1-[2,4-Bis(allylamino)-1,3,5-triazin-6-yl]-4-[bis(4-fluorophenyl)methyl]piperazine

2,4-Bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine

6-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]-N,N'-di(2-propenyl)-1,3,5-triazine-2,4-diamine

S-2620

AlMitrine Mesylate

Almitrine dimethanesulfonic acid

1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N2,N4-di-2-propen-1-yl-

ALMITRINE USP/EP/BP

27469-53-0

C26H29F2N7