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4,4'-Difluorobenzhydrylpiperazine

Product Name
4,4'-Difluorobenzhydrylpiperazine
CAS No.
27469-60-9
Chemical Name
4,4'-Difluorobenzhydrylpiperazine
Synonyms
1-Bis(4-fL;1-(4,4'TIMTEC-BB SBB002996;Flunarizine Impurity A;Flunarizine EP Impurity A;1-[Bis(4-Fluorophenyl)methyl]p;4,4-DIFLUOROBENZHYDRYLPIPERAZINE;4,4-Difluorobenzhydrolpiperazine;4,4'-Difluorobenzhydrylpiperazine;4,4'-DIFLUOROBENZHYDRYL PIPERAZINE
CBNumber
CB2161725
Molecular Formula
C17H18F2N2
Formula Weight
288.33
MOL File
27469-60-9.mol
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4,4'-Difluorobenzhydrylpiperazine Property

Melting point:
88-92 °C(lit.)
Boiling point:
130 °C
Density 
1.1462 (estimate)
vapor pressure 
0.001-0.003Pa at 20-25℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol,Toluene
pka
9.00±0.10(Predicted)
form 
Crystalline Powder
color 
White to yellow
Water Solubility 
0.34 g/L (20 ºC)
BRN 
620754
Stability:
Hygroscopic
InChI
InChI=1S/C17H18F2N2/c18-15-5-1-13(2-6-15)17(21-11-9-20-10-12-21)14-3-7-16(19)8-4-14/h1-8,17,20H,9-12H2
InChIKey
TTXIFFYPVGWLSE-UHFFFAOYSA-N
SMILES
N1(C(C2=CC=C(F)C=C2)C2=CC=C(F)C=C2)CCNCC1
LogP
3.3-3.5 at pH7-11
CAS DataBase Reference
27469-60-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45-36/37/39
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
F 
10-34
Hazard Note 
Toxic
HazardClass 
IRRITANT
HazardClass 
6.1
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
552402
Product name
1-Bis(4-fluorophenyl)methyl piperazine
Purity
97%
Packaging
5g
Price
$138
Updated
2023/06/20
TCI Chemical
Product number
B2764
Product name
1-Bis(4-fluorophenyl)methyl piperazine
Purity
>97.0%(GC)
Packaging
5g
Price
$57
Updated
2025/07/31
TCI Chemical
Product number
B2764
Product name
1-Bis(4-fluorophenyl)methyl piperazine
Purity
>97.0%(GC)
Packaging
25g
Price
$192
Updated
2025/07/31
TRC
Product number
B434875
Product name
1-Bis(4-fluorophenyl)methyl piperazine
Packaging
25g
Price
$185
Updated
2021/12/16
AK Scientific
Product number
O224
Product name
1-Bis(4-fluorophenyl)methyl piperazine
Packaging
5g
Price
$14
Updated
2021/12/16
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4,4'-Difluorobenzhydrylpiperazine Chemical Properties,Usage,Production

Chemical Properties

white to yellow crystalline powder

Uses

1-Bis(4-fluorophenyl)methyl piperazine may be used to synthesize 1-[bis(4-fluorophenyl)methyl]-4-[3-[(N-ethoxycarbonyl-N-phenyl)amino]-2-hydroxypropyl]piperazine and (R, S) 3-[4-(bis(4-fluorophenyl)methyl)piperazin-1-yl]dihydrofuran-2(3H)-one.

General Description

1-Bis(4-fluorophenyl)methyl piperazine is formed during the synthesis of flunarizine. Its crystals exhibits monoclinic crystal system and space group P21/c.

Synthesis

110-85-0

27064-94-4

27469-60-9

GENERAL METHODS: NaBH4 (0.6 mol) was added batchwise to a stirred solution of benzophenone (1.0 mol) in methanol (2 vol) for 45 min at room temperature. The reaction mixture was stirred at ambient temperature for 2-3 h (the progress of the reaction was monitored by TLC), followed by dilution with water (750 mL) and adjusting the pH with acetic acid to 4. Extraction was carried out with dichloromethane (2 x 400 mL), the organic layer was washed with water (200 mL), dried with anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to afford the pure benzophenol derivative as a white to off-white solid The yield was 93-97%. To a solution of diphenylmethanol derivative (1.0 mol) in toluene (370 mL) at room temperature, concentrated HCl (35% aqueous solution, 370 mL) and tetrabutylammonium bromide (0.01 mol) were added while stirring. The mixture was stirred continuously at 40-45 °C for 6-7 hours. After completion of the reaction (confirmed by TLC), it was cooled to room temperature. The organic layer was separated and concentrated under vacuum to give the crude diphenylmethyl chloride derivative as a light brown liquid in 95-97% yield. To a solution of diphenylmethyl chloride derivative (0.96 mol) in toluene (380 mL) at 60-70°C, anhydrous piperazine (5.0 mol) was slowly added over 45-60 minutes. The resulting mixture was heated at 90-100°C for 8-10 hours with stirring. After completion of the reaction, the mixture was cooled, water (380 mL) was added and the organic layer was separated. The organic layer was washed with a mixture of concentrated HCl and water (1:1, 2 x 350 mL) and neutralized with 20% NaOH solution (750 mL). The aqueous layer was again extracted with toluene (2 × 300 mL), and the organic layer was dried with anhydrous sodium sulfate and concentrated in vacuum to give pure 1-(bis(p-fluorophenyl)methyl)piperazine as a white to off-white solid in 88% yield.

References

[1] Journal of Medicinal Chemistry, 1997, vol. 40, # 13, p. 2047 - 2052
[2] Synthesis, 2010, # 12, p. 1989 - 1991
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1822 - 1826
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, vol. 29, # 2, p. 205 - 214
[5] Synthetic Communications, 2014, vol. 44, # 5, p. 600 - 609

4,4'-Difluorobenzhydrylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-Difluorobenzhydrylpiperazine Suppliers

Americas 1 Belgium 2 China 187 Europe 4 Germany 6 India 46 Japan 6 South Korea 1 Switzerland 3 Ukraine 2 United Kingdom 15 United States 41 Global 314
Shanghai Taijilin Industrial Co., Ltd.
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021-50630626 18964684208
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021-50563898
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kate@tajilin.com
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China
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Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd
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18072846723 18072846723
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2493446488@qq.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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Energy Chemical
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Wuhan Chemwish Technology Co., Ltd
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sales@chemwish.com
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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+86-21-54098501
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+86-21-54096319
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sales@sinch.com.cn
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View Lastest Price from 4,4'-Difluorobenzhydrylpiperazine manufacturers

Moxin Chemicals
Product
Flunarizine EP Impurity A 27469-60-9
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
100000
Release date
2025-03-19
Hebei Yanxi Chemical Co., Ltd.
Product
4,4'-Difluorobenzhydrylpiperazine 27469-60-9
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-07
Career Henan Chemical Co
Product
4,4'-Difluorobenzhydrylpiperazine 27469-60-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

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