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Lomerizine hydrochloride

Product Name
Lomerizine hydrochloride
CAS No.
101477-54-7
Chemical Name
Lomerizine hydrochloride
Synonyms
KB 2796;TERRANAS;Lomeizine HCL;Lomerizine2HCl;LOMERIZINE HCL;LOMERIZINE DIHCL;KB-2796, Terranas;KB-2796 dihydrochloride;LOMERIZINEHYDROCHLORTDE;LOMERIZINE HYDROCHLORIDE
CBNumber
CB5186585
Molecular Formula
C27H32Cl2F2N2O3
Formula Weight
541.46
MOL File
101477-54-7.mol
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Lomerizine hydrochloride Property

Melting point:
214-218°C dec.
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: ≥30mg/mL
form 
powder
color 
white to tan
Merck 
14,5563
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference
101477-54-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
TK9189000
HS Code 
29335990
Toxicity
LD50 orally in mice: 300 mg/kg (Ohtaka)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L6295
Product name
Lomerizine dihydrochloride
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$105
Updated
2024/03/01
Sigma-Aldrich
Product number
L6295
Product name
Lomerizine dihydrochloride
Purity
≥98% (HPLC), powder
Packaging
50mg
Price
$416
Updated
2024/03/01
TCI Chemical
Product number
L0245
Product name
Lomerizine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$308
Updated
2024/03/01
TCI Chemical
Product number
L0245
Product name
Lomerizine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
28374
Product name
Lomerizine (hydrochloride)
Packaging
250mg
Price
$68
Updated
2024/03/01
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Lomerizine hydrochloride Chemical Properties,Usage,Production

Description

Lomerizine hydrochloride was introduced as Teranas and Migsis in Japan for the treatment of migraine. It is the first in its class of dual sodium and calcium channel blockers to be marketed for this indication. It can be synthetically obtained by reductive amination of 2,3,4-trimethoxybenzaldehyde with the appropiate benzhydryl piperazine. In dogs, Lomerizine exerts a potent, selective and long-lasting vasodilation of cerebral arteries related to a combination of mechanisms, especially a functional block of L-type voltagesensitive calcium channels (L-VSCCs). Lomerizine increases cerebral blood flow compared to peripheral blood flow with only weak effects on systemic arterial blood pressure. Other mechanisms involved could be blockade of other VSCC and sodium channels, 5-HT2 and alpha-1 receptors. As a reducing agent of cortical spreading depression and neurogenic inflammation, Lomerizine was shown to be useful in migraine. In an open clinical study, it demonstrated efficacy in the treatment of cluster headache. Moreover, it may have utility in other neurological diseases such as cerebrovascular ischemia or cerebral infarction.

Chemical Properties

Colourless Crystalline Solid

Originator

Akzo Nobel (Netherlands)

Uses

A diphenylpiperazine calcium channel blocker. A selective cerebral vasodilator. Antimigraine.

brand name

Teranas;Migsis

References

1) Ishii?et al. (2009), Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery; ?J. Pharmacol. Sci. 111 221 2)?Hara et al. (2004), Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage; Cardiovasc.Drug Rev. 22 199 3)?Ishii et al. (2011), Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity; Mol. Cell Biochem. 358 1 4) Savigni?et al. (2013), Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma; ?Neuropharmacology 75 380 5) Tran?et al. (2014), The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD, but not TDP-43; ?J. Neurochem. 130 455 6) O’Hare?et al. (2016), Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro; ?Neuroscience 339 450

Lomerizine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Lomerizine hydrochloride Suppliers

Shandong Chenlong Pharmaceutical Co., Ltd.
Tel
0537-6460896
Fax
0537-6460806
Email
cx_04027@cisengroup.com
Country
CHINA
ProdList
23
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8836
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2866
Advantage
58
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View Lastest Price from Lomerizine hydrochloride manufacturers

Career Henan Chemical Co
Product
Lomerizine hydrochloride 101477-54-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-11

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