Trimetazidine dihydrochloride
Description References- Product Name
- Trimetazidine dihydrochloride
- CAS No.
- 13171-25-0
- Chemical Name
- Trimetazidine dihydrochloride
- Synonyms
- s4004;Takkmint;vastarel;kyurinett;Yoshimilon;Vastarel F;Youmetazine;Trimetazidine 3HCl;TRIMETAZIDINE 2HCL;TRIMETAZIDINE DI HCL
- CBNumber
- CB6176226
- Molecular Formula
- C14H24Cl2N2O3
- Formula Weight
- 339.26
- MOL File
- 13171-25-0.mol
Trimetazidine dihydrochloride Property
- Melting point:
- 231-235 °C(lit.)
- storage temp.
- Refrigerator
- solubility
- Freely soluble in water, sparingly soluble in alcohol.
- color
- White to Off-White
- Merck
- 14,9705
- Stability:
- Hygroscopic
- InChIKey
- XIRALXKCBGTYSC-UHFFFAOYSA-N
- CAS DataBase Reference
- 13171-25-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- TM2976100
- HazardClass
- IRRITANT
- HS Code
- 29339900
- Toxicity
- LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 653322
- Product name
- 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride
- Purity
- 97%
- Packaging
- 10g
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 653322
- Product name
- 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $286
- Updated
- 2024/03/01
- Product number
- 18165
- Product name
- Trimetazidine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 18165
- Product name
- Trimetazidine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- Y0000093
- Product name
- Trimetazidine for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000093
- Price
- $153
- Updated
- 2024/03/01
Trimetazidine dihydrochloride Chemical Properties,Usage,Production
Description
Trimetazidine dihydrochloride is the dihydrochloride salt of Trimetazidine. It is a drug used for the treatment of angina pectoris. It is capable of improving the left ventricular function in diabetic patients suffering coronary heart disease as well as treating the symptoms of patients suffering heart failure of different etiologies. It takes effects through acting as an anti- ischemic metabolic agent being capable of improving the utilization efficiency of myocardial glucose by inhibiting the metabolism of fatty acid (through inhibiting the activity of mitochondrial long- chain 3-ketoacyl coenzyme A Thiolase). The shift from fatty acid oxidation to glucose oxidation optimizes cellular energy process in cells exposed to hypoxia or ischaemia, further maintaining the intracellular ATP levels and ensuring the normal function of ionic pumps and transmembrane sodium-potassium flow to maintain cellular homeostasis.
References
Fragasso, G, et al. "A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure. " Journal of the American College of Cardiology 48.5 (2006):992.
Tuunanen, H, et al. "Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy."Circulation 118.12(2008):1250.
Kantor, P. F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase."Circulation Research 86.5(2000):580.
Stanley, W. C., and M. Marzilli. "Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. "Fundamental & Clinical Pharmacology 17.2(2003):133–145.
Kantor, Paul F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase." Circulation research 86.5 (2000): 580-588.
Description
Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.
Chemical Properties
Crystalline Solid
Uses
Antianoxic
Uses
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:
- Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
- Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.
Uses
Coronary vasodilator. Antianginal
Definition
ChEBI: Trimetazidine hydrochloride is an aromatic amine.
Trimetazidine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trimetazidine dihydrochloride manufacturers
- Product
- Trimetazidine dihydrochloride 13171-25-0
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98.5%-101.5% Titation;EP
- Supply Ability
- 1000 KGS
- Release date
- 2021-06-18
- Product
- Trimetazidine dihydrochloride 13171-25-0
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-11-08
- Product
- Trimetazidine dihydrochloride 13171-25-0
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-11-09