Trimetazidine dihydrochloride

ChemicalBook > CAS DataBase List > Trimetazidine dihydrochloride

Trimetazidine dihydrochloride

Description References

Product Name: Trimetazidine dihydrochloride
CAS No.: 13171-25-0
Chemical Name: Trimetazidine dihydrochloride
Synonyms: s4004;Takkmint;vastarel;kyurinett;Yoshimilon;Vastarel F;Youmetazine;Trimetazidine 3HCl;TRIMETAZIDINE 2HCL;TRIMETAZIDINE DI HCL
CBNumber: CB6176226
Molecular Formula: C14H24Cl2N2O3
Formula Weight: 339.26
MOL File: 13171-25-0.mol

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Trimetazidine dihydrochloride Property

Melting point:: 231-235 °C(lit.)
storage temp.: Refrigerator
solubility: Freely soluble in water, sparingly soluble in alcohol.
form: Solid
color: White to Off-White
Merck: 14,9705
Stability:: Hygroscopic
InChIKey: XIRALXKCBGTYSC-UHFFFAOYSA-N
CAS DataBase Reference: 13171-25-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: TM2976100
HazardClass: IRRITANT
HS Code: 29339900
Toxicity: LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 653322
Product name: 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride
Purity: 97%
Packaging: 10g
Price: $121
Updated: 2024/03/01

Sigma-Aldrich

Product number: 653322
Product name: 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride
Purity: 97%
Packaging: 25g
Price: $286
Updated: 2024/03/01

Cayman Chemical

Product number: 18165
Product name: Trimetazidine (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 18165
Product name: Trimetazidine (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $72
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000093
Product name: Trimetazidine for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000093
Price: $153
Updated: 2024/03/01

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Trimetazidine dihydrochloride Chemical Properties,Usage,Production

Description

Trimetazidine dihydrochloride is the dihydrochloride salt of Trimetazidine. It is a drug used for the treatment of angina pectoris. It is capable of improving the left ventricular function in diabetic patients suffering coronary heart disease as well as treating the symptoms of patients suffering heart failure of different etiologies. It takes effects through acting as an anti- ischemic metabolic agent being capable of improving the utilization efficiency of myocardial glucose by inhibiting the metabolism of fatty acid (through inhibiting the activity of mitochondrial long- chain 3-ketoacyl coenzyme A Thiolase). The shift from fatty acid oxidation to glucose oxidation optimizes cellular energy process in cells exposed to hypoxia or ischaemia, further maintaining the intracellular ATP levels and ensuring the normal function of ionic pumps and transmembrane sodium-potassium flow to maintain cellular homeostasis.

References

Fragasso, G, et al. "A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure. " Journal of the American College of Cardiology 48.5 (2006):992.
Tuunanen, H, et al. "Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy."Circulation 118.12(2008):1250.
Kantor, P. F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase."Circulation Research 86.5(2000):580.
Stanley, W. C., and M. Marzilli. "Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. "Fundamental & Clinical Pharmacology 17.2(2003):133–145.
Kantor, Paul F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase." Circulation research 86.5 (2000): 580-588.

Description

Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC₅₀ = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.

Chemical Properties

Crystalline Solid

Uses

Antianoxic

Uses

1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:

Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.

Uses

Coronary vasodilator. Antianginal

Definition

ChEBI: Trimetazidine hydrochloride is an aromatic amine.

Trimetazidine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Trimetazidine dihydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Trimetazidine dihydrochloride 13171-25-0
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98.5%-101.5% Titation;EP
Supply Ability: 1000 KGS
Release date: 2021-06-18

Hebei Zhanyao Biotechnology Co. Ltd

Product: Trimetazidine dihydrochloride 13171-25-0
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-08

Hebei Zhanyao Biotechnology Co. Ltd

Product: Trimetazidine dihydrochloride 13171-25-0
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-09

13171-25-0, Trimetazidine dihydrochloride Related Search:

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1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DIHYDROCHLORIDE

1-[(2,3,4-Trimethoxy-phenyl)methyl]piperazine Dihydrochloride

Vastarel F

Yoshimilon

1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride,Trimetazidine dihydrochloride

Trimetazidine 3HCl

Takkmint

Youmetazine

1-[2,3,4-TRIMETHOXYPHENYL)-METHYI] PIPERAZINE DIHYDROCHLORIDE

Sibutramine trimetazidine hydrochloride

1-(2,3,4-TriMethoxybenzyl)piperazine dihydrochloride 97%

1-((2,3,4-trimethoxyphenyl)methyl)-piperazindihydrochloride

1-(2,3,4-trimethoxybenzyl)-piperazindihydrochloride

kyurinett

s4004

vastarel

1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DI&

TRIMETAZIDINE DI HCL

TRIMETAZIDINE DIHYDROCHLORIDE

TRIMETAZIDINE HYDROCHLORIDE

TRIMETAZIDINE 2HCL

1-[[2,3,4-Trimethoxyphenyl] methyl] piperazine hydrochloride

Trimetazidine for system suitability CRS

Trimetazidine dihydrochloride/TRIMETAZIDINE 2HCL

Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)

Trimetazidine dihydrochloride USP/EP/BP

trimetazidine impurity1136

Trimetazidine dihydrochloride (Y0000092)

Trimetazidine DihydrochlorideQ: What is Trimetazidine Dihydrochloride Q: What is the CAS Number of Trimetazidine Dihydrochloride Q: What is the storage condition of Trimetazidine Dihydrochloride Q: What are the applications of Trimetazidine Dihydrochloride

1-(2,3,4-tetramethoxybenzyl)piperzine Di Hydrochloride

1-(2,3,4-Trimethoxybenzyl)piperazine Dihydrochloride, ≥ 98.0%

13171-25-0

C14H22N2O32HCl

C14H22N2O32HClC14H24Cl2

C14H22N2O32HClC14H24Cl2N2O3

C14H22N2O32ClH

Building Blocks

Heterocyclic Building Blocks

Piperazines

Building Blocks

C14 to C15

Chemical Synthesis

Heterocyclic Building Blocks

Piperazines

Intermediates & Fine Chemicals

Pharmaceuticals

13171-25-0

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