Drotaverine hydrochloride

Product Name: Drotaverine hydrochloride
CAS No.: 985-12-6
Chemical Name: Drotaverine hydrochloride
Synonyms: DROTAVERINE HCL;no-spa;NOSH-BRA;Tetraspasmin-Lef;tetraspasmin-lefa;no-spahydrochloride;D10-Drotaverine HCl;drotaveriniumchloride;2H10]-Drotaverine.HCl;Drotaverinehydrochlorid
CBNumber: CB9245093
Molecular Formula: C24H32ClNO4
Formula Weight: 433.97
MOL File: 985-12-6.mol

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Drotaverine hydrochloride Property

Melting point:: 208-212°C
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Yellow
InChI: InChI=1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13+;
InChIKey: JBFLYOLJRKJYNV-UNUAAEKOSA-N
SMILES: C1(=C/C2=CC=C(OCC)C(OCC)=C2)/C2=C(C=C(OCC)C(OCC)=C2)CCN/1.[H]Cl
CAS DataBase Reference: 985-12-6(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D6205
Product name: Drotaverine Hydrochloride
Packaging: 200MG
Price: $115
Updated: 2025/07/31

TCI Chemical

Product number: D6205
Product name: Drotaverine Hydrochloride
Packaging: 1G
Price: $345
Updated: 2025/07/31

Cayman Chemical

Product number: 20944
Product name: Drotaverine (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $69
Updated: 2024/03/01

Cayman Chemical

Product number: 20944
Product name: Drotaverine (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $259
Updated: 2024/03/01

Cayman Chemical

Product number: 20944
Product name: Drotaverine (hydrochloride)
Purity: ≥98%
Packaging: 100mg
Price: $449
Updated: 2024/03/01

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Drotaverine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Pale-Yellow Crystalline Solid

Uses

A papaverine analog

Uses

Analogue of Papaverine. Antispasmodic.

Biological Activity

Drotaverine (Drotaverin) is an isoquinoline-based PDE4-selective phosphodiesterase (PDE) inhibitor and an L-type voltage-dependent (voltage-operated) calcium channel (L-VDCC or L-VOCC) blocker th at exhibits in vivo antispasmodic efficacy without anticholinergic effects.', 'It is a benzylisoquinoline derivative. Drotaverine acts as a smooth muscle relaxant.

in vivo

Drotaverine (10-80 mg/kg, i.p., single dose) hydrochloride improves cognitive impairment and shows the ability to regulate levels of neurotransmitters in the brain^[3].

Animal Model:	STZ-induced AD white mice ^[3]
Dosage:	10, 20, 40, 80 mg/kg; single dose
Administration:	Intraperitoneal injection (i.p.)
Result:	Increased physical activity in a dose-dependent manner, with more time spent in the open arms, increased in the number of crossings and time spent in the north quadrant. Increased in brain antioxidant levels (SOD, CAT, GSH), a reduction in nitrite levels, and significant increased in serotonin, dopamine, and norepinephrine levels.

IC 50

L-type calcium channel; PDE4

Drotaverine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Drotaverine hydrochloride Suppliers

Canada 1 China 167 Europe 1 Germany 1 India 19 Russia 1 United Kingdom 7 United States 15 Global 212

Tianjin Zhangxin Pharmaceutical Technology Co., Ltd

Tel: 022-28219283 18522293726
Email: linda_zxyy@163.com
Country: China
ProdList: 41
Advantage: 58

Wuhan Xinru Chemical Co., Ltd.

Tel: 15927387915 15337108568
Email: 2769903731@qq.com
Country: China
ProdList: 3336
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824; 13184580281
Fax: 400-880-2824
Email: hj@ruiweier.cn
Country: China
ProdList: 2686
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

HUBEI HICKS BIOCHEMICAL CO.,LTD

Tel: 18696113233
Email: 15927219311@163.com
Country: China
ProdList: 1660
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1931
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

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View Lastest Price from Drotaverine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Drotaverine hydrochloride 985-12-6
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%-102%;USP
Supply Ability: 200kgs
Release date: 2021-07-06

Hebei Chuanghai Biotechnology Co., Ltd

Product: Drotaverine hydrochloride 985-12-6
Price: US $19.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-20

Shaanxi Dideu Medichem Co. Ltd

Product: Drotaverine hydrochloride 985-12-6
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-06

985-12-6, Drotaverine hydrochlorideRelated Search:

Methylene Blue 4,4'-Diphenylmethane diisocyanate Trimetazidine dihydrochloride Trazodone hydrochloride INTERMEDIATES FOOD ADDITIVES Amitriptyline hydrochloride Buflomedil hydrochloride Topotecan hydrochloride Mebeverine hydrochloride 1-AdaMantanethylaMine Drotaverin hydrochloride Methylene Chloride Tramadol hydrochloride Sibutramine hydrochloride Drotaverine hydrochloride Tetrahydro

1,2,3,4-Tetrahydro-6,7-diethoxy-1-((3,4-diethoxyphenyl) methylene)-isoquinoline hydrochloride

1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinolin

Tetraspasmin-Lef

(Z)-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

DROTAVERINE HYDROCHLORIDE

DROTAVERINE HCL

DROTAVERINE HCL ,1-[(3,4-DIETHOXYPHENYL)METHYLENE]-6,7-DIETHOXY 1,2,3,4-TETRAHYDROISOQUINOLINE HCL

Drotaverinehydrochlorid

drotaveriniumchloride

isoquinoline,1,2,3,4-tetrahydro-6,7-diethoxy-1-((3,4-diethoxyphenyl)methylene)

no-spa

no-spahydrochloride

tetraspasmin-lefa

1-(3,4-Diethoxybenzylidine)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride

NOSH-BRA

1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-3,4-dihydroisoquinoline hydrochloride

Isoquinoline,1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-,hydrochloride (1:1)

Drotaverine hydrochloride USP/EP/BP

Drotaverine D10 hydrochlorideQ: What is Drotaverine D10 hydrochloride Q: What is the CAS Number of Drotaverine D10 hydrochloride Q: What are the applications of Drotaverine D10 hydrochloride

Drotaverine HydrochlorideQ: What is Drotaverine Hydrochloride Q: What is the CAS Number of Drotaverine Hydrochloride Q: What is the storage condition of Drotaverine Hydrochloride Q: What are the applications of Drotaverine Hydrochloride

Drotaverine hydrochloride Powder USP Standard

2H10]-Drotaverine.HCl

3’-Desethoxy-drotaverine-d10

Drotaverine hydrochloride in methanol

Drotaverine hydrochloride, 10 mM in DMSO

Drotaverine HCl - Bio-X ?

D10-Drotaverine HCl

985-12-6

C24H31NO4HClC24H32ClNO4

C24H31NO4ClH

C24H31NO4

C24H32ClNO4

Intermediates & Fine Chemicals

Pharmaceuticals

Heterocycles

985-12-6