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Mebeverine hydrochloride

Product Name
Mebeverine hydrochloride
CAS No.
2753-45-9
Chemical Name
Mebeverine hydrochloride
Synonyms
MEBEVERINE;MEBEVERINE HCL;COLOFAC;csag-144;duspatalin;Colofac Hydrochloride;Duspatal Hydrochloride;MEBEVERINE HYDROCHLORIDE;Duspatalin Hydrochloride;Mebeverine HCL SR Pellets
CBNumber
CB2444585
Molecular Formula
C25H35NO5.ClH
Formula Weight
466.01
MOL File
2753-45-9.mol
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Mebeverine hydrochloride Property

Melting point:
105-107 C
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO : ≥ 155 mg/mL (332.61 mM)
form 
Solid
pka
pKa 9.07± 0.02(40% EtOH,t =25,) (Uncertain)
color 
White to off-white
CAS DataBase Reference
2753-45-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-26
WGK Germany 
3
RTECS 
YX5425000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M202490
Product name
Mebeverine hydrochloride
Packaging
1g
Price
$185
Updated
2021/12/16
Matrix Scientific
Product number
159619
Product name
4-{Ethyl[2-(4-methoxyphenyl)-1-methylethyl]amino}butyl 3,4-dimethoxybenzoate hydrochloride
Packaging
1g
Price
$200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003268
Product name
MEBEVERINE HYDROCHLORIDE
Purity
95.00%
Packaging
2.5MG
Price
$300
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003268
Product name
MEBEVERINE HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$704.55
Updated
2021/12/16
AK Scientific
Product number
Q712
Product name
MebeverineHCl
Packaging
25mg
Price
$91
Updated
2021/12/16
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Mebeverine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Duspatalin,Duphar,France,1965

Uses

muscarinic ACh agonist, antiglaucoma

Uses

Smooth muscle relaxant. Antispasmodic.

Manufacturing Process

(A) Sodium-3,4-Dimethoxybenzoate: A solution of 91 g of 3,4- dimethoxybenzoic acid in 500 ml of boiling, absolute alcohol was added quickly to a solution of 11.5 g of sodium in 300 ml of absolute alcohol; after cooling to room temperature the resulting precipitate was filtered off and washed with 2 x 50 ml of absolute alcohol and 4 x 200 ml of ether and dried in air to constant weight; yield 92.5 g, MP about 265°C. The filtrate was bulked with the alcohol and ether washings, left to stand overnight, and a further precipitate then filtered off, washed with 3 x 100 ml of ether, and dried in air to constant weight. Yield 22.5 g, MP about 265°C. Total yield therefore 115 g (=113%).
(B) 4'-Chlorobutyl-3,4-Dimethoxybenzoate: 92 g of the sodium salt described under (A) (it contains at the most 81.5 g of sodium 3,4-dimethoxybenzoate) was boiled in 900 ml of tetramethylene dichloride for 90 hours; after cooling the mixture was filtered and the residue washed with 3 x 50 ml of ether. The filtrate was evaporated to dryness in vacuo and the residue (102 g) was distilled in vacuo. Fraction 1: 50° to 55°C/0.5 mm; 19 g (probably tetramethylene dichloride). Fraction 2: 175° to 184°C/0.5 mm; 77.5 g (=71%); Cl= 12.6% (calculated 13.0%). Remark: The second fraction partially solidified or became more viscous on standing, and even during the distillation.
(C) 4'-Iodobutyl-3,4-Dimethoxybenzoate: 32.5 g of 4'-chlorobutyl-3,4- dimethoxybenzoate and 19.5 g of sodium iodide (10% excess) were boiled in 150 ml of methyl ethyl ketone for 2.5 hours; after cooling and filtering off the sodium chloride produced, the reaction was found not to be entirely completed; boiling was then continued for another two hours; the reaction mixture was cooled, and the solid filtered off and washed with 2 x 100 ml of ether.
The filtrate was evaporated to dryness in vacuo and the residue was dissolved in 300 ml of ether and 100 ml of water; the layers were separated and the water layer was once again extracted with 100 ml of ether; then the ether layers were boiled and washed again with a solution of 3.5 g of sodium thiosulfate in 100 ml of water. The ether layer was dried over sodium sulfate. Finally the solution was filtered and the ether was evaporated; the residue was an almost colorless oil, which partially solidified or became more viscous after being left to stand for some time. Yield: 40 g (=92%), I=34.2% (calculated 34.9%).
(D) 4'-[N-Ethyl-1''-Methyl-2''-(4'''-Methoxyphenyl)Ethylamino]Butyl-3,4- Dimethoxybenzoate Hydrochloride: 10.3 g of 4'-iodobutyl-3,4- dimethoxybenzoate and 11.0 g of N-ethyl-p-methoxyphenylisopropylamine (obtained by catalytic reduction of an alcoholic solution of an excess quantity (60%) of p-methoxy-phenyl-acetone, to which was added a 33% (weight-for-weight) aqueous solution of ethylamine, with Pt as a catalyst), were boiled in 200 ml of methyl ethyl ketone for 20 hours, cooled and the iodine ion was determined; the reaction was found to be complete. Then the methyl ethyl ketone was evaporated in vacuo and the residue was dissolved in 300 ml of water and 30 ml of ether; the layers were separated and the water layer was extracted twice more with 20 ml portions of ether.

Therapeutic Function

Spasmolytic

Mebeverine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Mebeverine hydrochloride Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Jai Radhe Sales
Tel
+(91)-(79)-26431096/65255722
Fax
+(91)-(79)-26569884
Email
info@jairadhesales.com
Country
India
ProdList
397
Advantage
60
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View Lastest Price from Mebeverine hydrochloride manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
Mebeverine hydrochloride 2753-45-9
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-10
Career Henan Chemical Co
Product
Mebeverine hydrochloride 2753-45-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-11

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