Flocoumafen Property

Melting point:

181 °C

Boiling point:

672.4±55.0 °C(Predicted)

Density 

1.2 g/cm3

vapor pressure 

1.33 x l0^-10 Pa (25 °C)

Flash point:

23 °C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

Water Solubility 

1.1 mg l^-1

pka

4.50±1.00(Predicted)

color 

White to off-white

InChIKey

KKBGNYHHEIAGOH-UHFFFAOYSA-N

EPA Substance Registry System

2H-1-Benzopyran-2-one, 4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1-naphthalenyl]- (90035-08-8)

Safety

Hazard Codes 

T+,N

Risk Statements 

26/27/28-48/23/24/25-50/53

Safety Statements 

28-36/37/39-45-60-61

RIDADR 

3027

WGK Germany 

3

RTECS 

DJ3100300

HazardClass 

6.1(a)

PackingGroup 

I

Hazardous Substances Data

90035-08-8(Hazardous Substances Data)

Toxicity

LD50 in rats, mice, rabbits (mg/kg): 0.25, 0.8, 0.2 orally (Bowler)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Flocoumafen Chemical Properties,Usage,Production

Uses

Flocoumafen is used to control rodents around buildings. It also has some use in field and plantation crops including cocoa, cotton, oilpalm, rice and sugar cane.

Uses

Flocoumafen is a second-generation anti-coagulant used as a rodenticide. It has a very high toxicity and is restricted to indoor use and sewers (in the United Kingdom). This restriction is mainly due to the increased risk to non-target species. Studies have shown that rodents resistant to first-generation anti-coagulants can be adequately controlled with flocoumafen. The chemical substance is off-white solid, does not mix well with water (1.1 mg/L), and is sparingly soluble in acetone, ethanol, xylene, and octanol. Flocoumafen is stable to hydrolysis. Because of the acute toxicity of flocoumafen and its intended use as a rodenticide, chronic toxicity studies have not been reported. However, flocoumafen is known to cause adverse health effects and abnormal prothrombin.

Definition

ChEBI: Flocoumafen is a ring assembly, a member of naphthalenes and a member of benzenes.

Metabolic pathway

Flocoumafen exists as cis and trans isomers (Scheme 1). The tetralin ring adopts its most stable conformation in each case and the two forms have very similar shapes. Both are active rodenticides. The fate of flocoumafen in soils and plants has not been studied in detail because the compound is usually used as a pelleted bait or in a wax block. This limits its dissipation in the environment. Studies in animals and birds have been conducted as part of the assessment of safety and to investigate mode of action. Metabolism is slow in the rat and rapid in Japanese quail but this difference should be interpreted with care because of the 100-fold difference in dose used (see also Overview).

Degradation

Flocoumafen is a stable compound; no detectable degradation occurs at 50 °C at pH 7-9 over 4 weeks.