Boc-L-glutamic acid 1-tert-butyl ester

Product Name: Boc-L-glutamic acid 1-tert-butyl ester
CAS No.: 24277-39-2
Chemical Name: Boc-L-glutamic acid 1-tert-butyl ester
Synonyms: BOC-GLU-OTBU;BOC-L-;(S)-5-(tert-butoxy)-4-((tert-butoxycarbonyl)aMino)-5-oxopentanoic acid;BOC-L-GLU-OTBU;u-OtBu;EOS-61895;BOC-GLU-OBUT;Boc-Glu-OtBu,>98%;BOC-GLUTAMIC ACID-OTBU;BOC-GLU-OTBU (24277-39-2)
CBNumber: CB6671468
Molecular Formula: C14H25NO6
Formula Weight: 303.35
MOL File: 24277-39-2.mol

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Boc-L-glutamic acid 1-tert-butyl ester Property

Melting point:: 111.0 to 115.0 °C
Boiling point:: 449.8±40.0 °C(Predicted)
Density: 1.121±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in dimethyl formamide.
form: powder to crystaline
pka: 4.48±0.10(Predicted)
color: White to Almost white
optical activity: -30.8554° (C=1.0042 g/100ml, MEOH)
BRN: 3653769
InChI: InChI=1S/C14H25NO6/c1-13(2,3)20-11(18)9(7-8-10(16)17)15-12(19)21-14(4,5)6/h9H,7-8H2,1-6H3,(H,15,19)(H,16,17)/t9-/m0/s1
InChIKey: YMOYURYWGUWMFM-VIFPVBQESA-N
SMILES: C(OC(C)(C)C)(=O)[C@H](CCC(O)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference: 24277-39-2(CAS DataBase Reference)

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Safety

Risk Statements: 22/22-36/37/38
Safety Statements: 4-7-28-35-44
WGK Germany: 3
HS Code: 2924 19 00

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B2522
Product name: Boc-Glu-OtBu
Packaging: 5g
Price: $348.53
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53028
Product name: Boc-Glu-OtBu
Purity: Novabiochem?
Packaging: 25g
Price: $425
Updated: 2025/07/31

TCI Chemical

Product number: B4534
Product name: 1-tert-Butyl N-(tert-Butoxycarbonyl)-L-glutamate
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: B4534
Product name: 1-tert-Butyl N-(tert-Butoxycarbonyl)-L-glutamate
Purity: >97.0%(HPLC)(T)
Packaging: 25g
Price: $148
Updated: 2025/07/31

Usbiological

Product number: 264387
Product name: Boc-L-glutamic acid a-t-butyl ester
Packaging: 5g
Price: $422
Updated: 2021/12/16

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Boc-L-glutamic acid 1-tert-butyl ester Chemical Properties,Usage,Production

Chemical Properties

White powder crystal

Uses

Boc-Glu-OtBu is an N-terminal protected amino acid used in solid-phase peptide synthesis (SPPS) to make unique peptides containing glutamate tert-butyl ester residues.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24277-38-1

24277-39-2

General procedure for the synthesis of Boc-L-glutamic acid 1-tert-butyl ester from (S)-1-tert-butyl 5-methyl 2-((tert-butoxycarbonyl)amino)pentanedioate: crude N-Boc-glutamic acid 1-tert-butyl ester (5-methyl ester from the previous step, 30.4 g, 95.8 mmol) was dissolved in THF (300 mL), 1N LiOH was added aqueous solution (144 mL). The reaction mixture was stirred at room temperature for 40 min and the progress of the reaction was monitored by TLC to confirm complete consumption of the feedstock. Upon completion of the reaction, THF was removed using a rotary evaporator.The remaining aqueous phase was extracted with ethyl acetate (3 × 100 mL) and subsequently acidified with solid citric acid to pH 4. The acidified aqueous phase was again extracted with ethyl acetate (3 × 100 mL). All the ethyl acetate extracts were combined, washed with saturated brine (2×50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to give the target product Boc-L-glutamic acid-1-tert-butyl ester as a colorless oil. Yield: 25 g (92% yield, calculated based on Boc-Glu(OMe)-OH). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) and 13C NMR (75 MHz, CDCl3).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 13, p. 3793 - 3797
[2] Journal of Organic Chemistry, 2005, vol. 70, # 22, p. 8730 - 8733
[3] Russian Chemical Bulletin, 2010, vol. 59, # 1, p. 110 - 115
[4] Journal of the American Chemical Society, 1993, vol. 115, # 15, p. 6646 - 6651
[5] Tetrahedron Letters, 2003, vol. 44, # 28, p. 5251 - 5253

Boc-L-glutamic acid 1-tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-L-glutamic acid 1-tert-butyl ester manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Boc-L-glutamic acid 1-tert-butyl ester 24277-39-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2025-04-01

Shaanxi Haibo Biotechnology Co., Ltd

Product: Boc-L-glutamic acid 1-tert-butyl ester 24277-39-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-28

Career Henan Chemical Co

Product: Boc-L-glutamic acid 1-tert-butyl ester 24277-39-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-16

24277-39-2, Boc-L-glutamic acid 1-tert-butyl esterRelated Search:

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High Quality Boc-L-glutamic acid 1-tert-butyl ester

BOC-L-glutamate-1-tert-butyl ester

24277-39-2

C14H25NO6

Specialty Synthesis

Peptide Synthesis

A - H

Modified Amino Acids

Amino Acid Derivatives

BioChemical