DIFOPEIN
- Product Name
- DIFOPEIN
- CAS No.
- 396834-58-5
- Chemical Name
- DIFOPEIN
- Synonyms
- DIFOPEIN;M.W. 6387.17 C273H424N76O89S6
- CBNumber
- CB6675527
- Molecular Formula
- C273H424N76O89S6
- Formula Weight
- 6387.13
- MOL File
- 396834-58-5.mol
DIFOPEIN Property
- storage temp.
- Store at -20°C
- Water Solubility
- Soluble to 5 mg/ml in Water
N-Bromosuccinimide Price
- Product number
- 255139
- Product name
- Difopein
- Packaging
- 100ug
- Price
- $573
- Updated
- 2021/12/16
- Product number
- PRO0000351
- Product name
- DIFOPEIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.48
- Updated
- 2021/12/16
DIFOPEIN Chemical Properties,Usage,Production
Description
Difopein is an inhibitor of 14-3-3 protein.
14-3-3 protein has been involved in a wide range of biologic processes such as signal transduction, vesicular transport, cell cycle control, DNA replication, DNA repair and apoptosis. 14-3-3 protein has been associated with tumor genesis. 14-3-3 protein correlates with reduced tumor cell apoptosis and abbreviated patient survival. Up-regulation of 14-3-3 protein provides a survival advantage to tumor cells. Inhibition of 14-3-3 protein might trigger apoptosis, inhibit growth of established tumors, suppress de novo tumor formation, and promise a novel therapeutic approach for glioma treatment [1].
In human glioma U251 and U87 cells, difopein resulted in apoptosis characteristics, such as nuclear fragmentation, DNA laddering fragment and appearance of membrane-enclosed apoptotic bodies. Difopein induced apoptosis in a time-dependent manner [1]. Difopein induced glioma cell apoptosis through down-regulating Bcl-2, up-regulating Bax and activating caspase-9 and caspase-3. In vivo, difopein effectively hindered proliferation and triggered apoptosis of tumor cells implanted into nude mice [1].
References
[1] Cao W, Yang X, Zhou J, et al. Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice[J]. Apoptosis, 2010, 15(2): 230-241.
DIFOPEIN Preparation Products And Raw materials
Raw materials
Preparation Products
DIFOPEIN Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15185
- Advantage
- 58
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- eric@peptidego.com
- Country
- China
- ProdList
- 6347
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10523
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30255
- Advantage
- 58
- Tel
- 888-4366503
- Fax
- 888-502-1736
- sales@amelpharmatech.com
- Country
- China
- ProdList
- 5351
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14092
- Advantage
- 58
- Tel
- 0571-88211921 13355716090
- Sales@gotopbio.com
- Country
- China
- ProdList
- 2831
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 0571-88211921 15572296305
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5144
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 5950
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- 15888826472@163.com
- Country
- China
- ProdList
- 2729
- Advantage
- 58
- Tel
- 19961912513
- sales@hongtide.com
- Country
- China
- ProdList
- 4545
- Advantage
- 58
- Tel
- 18014456767 18014456767
- wenxi@jszkhy.com
- Country
- China
- ProdList
- 1349
- Advantage
- 58
- Tel
- 0512-51886999 17706251929
- office@combiosz.com
- Country
- China
- ProdList
- 2224
- Advantage
- 58
- Tel
- 0571-88211951 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 4904
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12007
- Advantage
- 58
- Tel
- 0571-85350119 13305819357
- bptsales@163.com
- Country
- China
- ProdList
- 3610
- Advantage
- 58
- Tel
- +86-755-89396905 +86-15013857715
- admin@nexconn.com
- Country
- China
- ProdList
- 10248
- Advantage
- 58
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 43348
- Advantage
- 58
- Tel
- +8617531972939
- anna@api-made.com
- Country
- China
- ProdList
- 2944
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1985563437@qq.com
- Country
- CHINA
- ProdList
- 6172
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6979
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15800446246@163.com
- Country
- CHINA
- ProdList
- 5417
- Advantage
- 58
- Tel
- --
- Fax
- --
- john.st@163.com
- Country
- CHINA
- ProdList
- 1472
- Advantage
- 58
- Tel
- --
- Fax
- --
- 596799915@QQ.COM
- Country
- CHINA
- ProdList
- 2905
- Advantage
- 58
- Tel
- --
- Fax
- --
- SHYIJIEBIO@126.COM
- Country
- CHINA
- ProdList
- 3510
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@f-biology.com
- Country
- CHINA
- ProdList
- 6039
- Advantage
- 58