DIFOPEIN
- Product Name
- DIFOPEIN
- CAS No.
- 396834-58-5
- Chemical Name
- DIFOPEIN
- Synonyms
- DIFOPEIN;M.W. 6387.17 C273H424N76O89S6
- CBNumber
- CB6675527
- Molecular Formula
- C273H424N76O89S6
- Formula Weight
- 6387.13
- MOL File
- 396834-58-5.mol
DIFOPEIN Property
- storage temp.
- Store at -20°C
- Water Solubility
- Soluble to 5 mg/ml in Water
N-Bromosuccinimide Price
- Product number
- 255139
- Product name
- Difopein
- Packaging
- 100ug
- Price
- $573
- Updated
- 2021/12/16
- Product number
- PRO0000351
- Product name
- DIFOPEIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.48
- Updated
- 2021/12/16
DIFOPEIN Chemical Properties,Usage,Production
Description
Difopein is an inhibitor of 14-3-3 protein.
14-3-3 protein has been involved in a wide range of biologic processes such as signal transduction, vesicular transport, cell cycle control, DNA replication, DNA repair and apoptosis. 14-3-3 protein has been associated with tumor genesis. 14-3-3 protein correlates with reduced tumor cell apoptosis and abbreviated patient survival. Up-regulation of 14-3-3 protein provides a survival advantage to tumor cells. Inhibition of 14-3-3 protein might trigger apoptosis, inhibit growth of established tumors, suppress de novo tumor formation, and promise a novel therapeutic approach for glioma treatment [1].
In human glioma U251 and U87 cells, difopein resulted in apoptosis characteristics, such as nuclear fragmentation, DNA laddering fragment and appearance of membrane-enclosed apoptotic bodies. Difopein induced apoptosis in a time-dependent manner [1]. Difopein induced glioma cell apoptosis through down-regulating Bcl-2, up-regulating Bax and activating caspase-9 and caspase-3. In vivo, difopein effectively hindered proliferation and triggered apoptosis of tumor cells implanted into nude mice [1].
References
[1] Cao W, Yang X, Zhou J, et al. Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice[J]. Apoptosis, 2010, 15(2): 230-241.