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3-Chloro-4-hydroxybenzotrifluoride

Product Name
3-Chloro-4-hydroxybenzotrifluoride
CAS No.
35852-58-5
Chemical Name
3-Chloro-4-hydroxybenzotrifluoride
Synonyms
3-Chloro-4-hydroxybe;2-chloro-4-trifluoromethylphenl;2-Chloro-4-(trifuloromethyl)phenol;3-CHLORO-4-HYDROXYBENZOTRIFLUORIDE;2-CHLORO-4-(TRIFLUOROMETHYL)PHENOL;3-chloro-4-hydroxytrifluoromethylene;Phenol, 2-chloro-4-(trifluoromethyl)-;3-Chloro-4-hydroxybenzotrifluoride98%;3-Chloro-4-hydroxybenzotrifluoride 98%;2-chloro-4-(trifluoromethyl)phenol - [C86577]
CBNumber
CB6678371
Molecular Formula
C7H4ClF3O
Formula Weight
196.55
MOL File
35852-58-5.mol
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3-Chloro-4-hydroxybenzotrifluoride Property

Boiling point:
66°C/13mmHg(lit.)
Density 
1.474±0.06 g/cm3(Predicted)
refractive index 
1.4740 to 1.4780
Flash point:
68°C(lit.)
storage temp. 
2-8°C
form 
clear liquid
pka
7.09±0.18(Predicted)
color 
Colorless to Light yellow
InChI
InChI=1S/C7H4ClF3O/c8-5-3-4(7(9,10)11)1-2-6(5)12/h1-3,12H
InChIKey
YNWKEXMSQQUMEL-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(C(F)(F)F)C=C1Cl
CAS DataBase Reference
35852-58-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS003105
Product name
2-Chloro-4-(trifluoromethyl)phenol
Purity
AldrichCPR
Packaging
250mg
Price
$68.1
Updated
2023/01/07
TCI Chemical
Product number
C3355
Product name
2-Chloro-4-(trifluoromethyl)phenol
Purity
>98.0%(GC)
Packaging
5g
Price
$128
Updated
2025/07/31
TCI Chemical
Product number
C3355
Product name
2-Chloro-4-(trifluoromethyl)phenol
Purity
>98.0%(GC)
Packaging
25g
Price
$513
Updated
2025/07/31
TRC
Product number
C597128
Product name
2-Chloro-4-(trifluoromethyl)phenol
Packaging
100mg
Price
$60
Updated
2021/12/16
Oakwood
Product number
004473
Product name
3-Chloro-4-hydroxybenzotrifluoride
Purity
97%
Packaging
25g
Price
$60
Updated
2021/12/16
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3-Chloro-4-hydroxybenzotrifluoride Chemical Properties,Usage,Production

Synthesis

402-45-9

35852-58-5

1. Oxidation: 4-(Trifluoromethyl)benzaldehyde (1.54 g, 6.75 mmol, 1.0 eq.) and dichloromethane (20 mL) were added to a round-bottomed flask and m-chloroperoxybenzoic acid (mCPBA, 1.52 g, 6.78 mmol, 1.0 eq.) was added slowly at room temperature. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium bisulfite solution (15 mL). The mixture was transferred to a partition funnel and extracted with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 4-(trifluoromethyl)phenol in 71% yield. 2. Chlorination reaction: N-chlorosuccinimide (NCS, 25.0 mmol, 3.4 g) and dichloromethane (20.0 mL) were added to another round-bottomed flask and cooled to -78 °C. The reaction was carried out by adding zirconium tetrachloride (ZrCl2) to the mixture. Zirconium tetrachloride (ZrCl4, 0.5 mmol, 300 mg) was added, followed by 4-(trifluoromethyl)phenol (25.0 mmol). The reaction mixture was warmed to room temperature and stirred for 6 hours. After completion of the reaction, it was extracted with saturated aqueous sodium bicarbonate. The organic phases were combined and the solvent was removed under reduced pressure to afford 2-chloro-4-(trifluoromethyl)phenol in 88% yield.

References

[1] Patent: US4607128, 1986, A
[2] Journal of the American Chemical Society, 2009, vol. 131, p. 4031 - 4041
[3] Patent: CN107915584, 2018, A. Location in patent: Paragraph 0025; 0026; 0027; 0028
[4] Patent: CN108276254, 2018, A. Location in patent: Paragraph 0012; 0013; 0014; 0015
[5] Patent: US4076741, 1978, A

3-Chloro-4-hydroxybenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

Acifluorfen Lactofen
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3-Chloro-4-hydroxybenzotrifluoride Suppliers

Americas 1 China 125 Europe 3 France 1 Germany 3 India 4 Italy 1 Japan 1 United Kingdom 10 United States 19 Global 168
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 3-Chloro-4-hydroxybenzotrifluoride manufacturers

Hubei Lidu New Material Technology Co., Ltd
Product
3-Chloro-4-hydroxybenzotrifluoride 35852-58-5
Price
US $0.00-0.00/G
Min. Order
1G
Purity
98%
Supply Ability
20TONS
Release date
2025-11-04
Shaanxi Dideu Medichem Co. Ltd
Product
3-Chloro-4-hydroxybenzotrifluoride 35852-58-5
Price
US $0.00-0.00/KG
Min. Order
50mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-08
Career Henan Chemical Co
Product
3-Chloro-4-hydroxybenzotrifluoride 35852-58-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-24

35852-58-5, 3-Chloro-4-hydroxybenzotrifluorideRelated Search:

Oxyfluorfen 3-Chloro-4-hydroxybenzotrifluoride 3-(2-CHLORO-4-TRIFLUOROMETHYLPHENOXY)BENZOIC ACID 5-(2-Chloro-4-(trifluoro-methyl)phenoxy)-2-nitro-benzoic acid sodium salt Fomesafen Fluoroglycofen-ethyl 4-(2,6-DICHLORO-4-TRIFLUOROMETHYL-PHENOXY)-PHENYLAMINE Acifluorfen Flufenoxuron ACIFLUORFEN METHYL ESTER Lactofen Fomesafen sodium 2-Chloro-3-hydroxybenzotrifluoride98%,2-CHLORO-3-HYDROXYBENZOTRIFLUORIDE,2-Chloro-3-hydroxybenzotrifluoride 98% 3-Chloro-5-hydroxyBenzotrifluoride 2-Chloro-5-hydroxybenzotrifluoride 98%,2-CHLORO-5-HYDROXYBENZOTRIFLUORIDE,2-Chloro-5-hydroxybenzotrifluoride98% 4-CHLORO-3-HYDROXYBENZOTRIFLUORIDE,4-Chloro-3-hydroxybenzotrifluoride 98%,4-Chloro-3-hydroxybenzotrifluoride98% Benzotrifluoride NITROFLUORFEN

  • 3-Chloro-4-hydroxybenzotrifluoride 98%
  • 3-Chloro-4-hydroxybenzotrifluoride98%
  • 2-CHLORO-4-(TRIFLUOROMETHYL)PHENOL
  • 3-CHLORO-4-HYDROXYBENZOTRIFLUORIDE
  • 2-Chloro-4-(trifuloromethyl)phenol
  • 2-Chloro-4-(trifluoromethyl)phenol, 3-Chloro-4-hydroxy-alpha,alpha,alpha-trifluorotoluene
  • 3-Chloro-4-hydroxybenzotrifluoride[2-Chloro-4-(trifluoroMethyl)phenol]
  • 3-Chloro-4-hydroxybe
  • 2-chloro-4-trifluoromethylphenl
  • Phenol, 2-chloro-4-(trifluoromethyl)-
  • 3-chloro-4-hydroxytrifluoromethylene
  • 2-chloro-4-(trifluoromethyl)phenol - [C86577]
  • 35852-58-5
  • C7H4OClF3
  • Fluorine series
  • Phenol&Thiophenol&Mercaptan