ChemicalBook > CAS DataBase List > 3-Chloro-4-hydroxybenzotrifluoride

3-Chloro-4-hydroxybenzotrifluoride

Product Name: 3-Chloro-4-hydroxybenzotrifluoride
CAS No.: 35852-58-5
Chemical Name: 3-Chloro-4-hydroxybenzotrifluoride
Synonyms: 3-Chloro-4-hydroxybe;2-chloro-4-trifluoromethylphenl;2-Chloro-4-(trifuloromethyl)phenol;3-CHLORO-4-HYDROXYBENZOTRIFLUORIDE;2-CHLORO-4-(TRIFLUOROMETHYL)PHENOL;3-chloro-4-hydroxytrifluoromethylene;Phenol, 2-chloro-4-(trifluoromethyl)-;3-Chloro-4-hydroxybenzotrifluoride98%;3-Chloro-4-hydroxybenzotrifluoride 98%;2-chloro-4-(trifluoromethyl)phenol - [C86577]
CBNumber: CB6678371
Molecular Formula: C7H4ClF3O
Formula Weight: 196.55
MOL File: 35852-58-5.mol

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3-Chloro-4-hydroxybenzotrifluoride Property

Boiling point:: 66°C/13mmHg(lit.)
Density: 1.474±0.06 g/cm3(Predicted)
refractive index: 1.4740 to 1.4780
Flash point:: 68°C(lit.)
storage temp.: 2-8°C
form: clear liquid
pka: 7.09±0.18(Predicted)
color: Colorless to Light yellow
InChI: InChI=1S/C7H4ClF3O/c8-5-3-4(7(9,10)11)1-2-6(5)12/h1-3,12H
InChIKey: YNWKEXMSQQUMEL-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(C(F)(F)F)C=C1Cl
CAS DataBase Reference: 35852-58-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003105
Product name: 2-Chloro-4-(trifluoromethyl)phenol
Purity: AldrichCPR
Packaging: 250mg
Price: $68.1
Updated: 2023/01/07

TCI Chemical

Product number: C3355
Product name: 2-Chloro-4-(trifluoromethyl)phenol
Purity: >98.0%(GC)
Packaging: 5g
Price: $128
Updated: 2025/07/31

TCI Chemical

Product number: C3355
Product name: 2-Chloro-4-(trifluoromethyl)phenol
Purity: >98.0%(GC)
Packaging: 25g
Price: $513
Updated: 2025/07/31

TRC

Product number: C597128
Product name: 2-Chloro-4-(trifluoromethyl)phenol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 002533
Product name: 3-Chloro-4-hydroxybenzotrifluoride
Purity: 97%
Packaging: 5g
Price: $14
Updated: 2021/12/16

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3-Chloro-4-hydroxybenzotrifluoride Chemical Properties,Usage,Production

Synthesis

402-45-9

35852-58-5

1. Oxidation: 4-(Trifluoromethyl)benzaldehyde (1.54 g, 6.75 mmol, 1.0 eq.) and dichloromethane (20 mL) were added to a round-bottomed flask and m-chloroperoxybenzoic acid (mCPBA, 1.52 g, 6.78 mmol, 1.0 eq.) was added slowly at room temperature. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium bisulfite solution (15 mL). The mixture was transferred to a partition funnel and extracted with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 4-(trifluoromethyl)phenol in 71% yield. 2. Chlorination reaction: N-chlorosuccinimide (NCS, 25.0 mmol, 3.4 g) and dichloromethane (20.0 mL) were added to another round-bottomed flask and cooled to -78 °C. The reaction was carried out by adding zirconium tetrachloride (ZrCl2) to the mixture. Zirconium tetrachloride (ZrCl4, 0.5 mmol, 300 mg) was added, followed by 4-(trifluoromethyl)phenol (25.0 mmol). The reaction mixture was warmed to room temperature and stirred for 6 hours. After completion of the reaction, it was extracted with saturated aqueous sodium bicarbonate. The organic phases were combined and the solvent was removed under reduced pressure to afford 2-chloro-4-(trifluoromethyl)phenol in 88% yield.

References

[1] Patent: US4607128, 1986, A
[2] Journal of the American Chemical Society, 2009, vol. 131, p. 4031 - 4041
[3] Patent: CN107915584, 2018, A. Location in patent: Paragraph 0025; 0026; 0027; 0028
[4] Patent: CN108276254, 2018, A. Location in patent: Paragraph 0012; 0013; 0014; 0015
[5] Patent: US4076741, 1978, A

3-Chloro-4-hydroxybenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

Acifluorfen Lactofen

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View Lastest Price from 3-Chloro-4-hydroxybenzotrifluoride manufacturers

Hubei Lidu New Material Technology Co., Ltd

Product: 3-Chloro-4-hydroxybenzotrifluoride 35852-58-5
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 20TONS
Release date: 2025-11-04

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Chloro-4-hydroxybenzotrifluoride 35852-58-5
Price: US $0.00-0.00/KG
Min. Order: 50mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-08

Career Henan Chemical Co

Product: 3-Chloro-4-hydroxybenzotrifluoride 35852-58-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-24

35852-58-5, 3-Chloro-4-hydroxybenzotrifluorideRelated Search:

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3-Chloro-4-hydroxybenzotrifluoride 98%

3-Chloro-4-hydroxybenzotrifluoride98%

2-CHLORO-4-(TRIFLUOROMETHYL)PHENOL

3-CHLORO-4-HYDROXYBENZOTRIFLUORIDE

2-Chloro-4-(trifuloromethyl)phenol

2-Chloro-4-(trifluoromethyl)phenol, 3-Chloro-4-hydroxy-alpha,alpha,alpha-trifluorotoluene

3-Chloro-4-hydroxybenzotrifluoride[2-Chloro-4-(trifluoroMethyl)phenol]

3-Chloro-4-hydroxybe

2-chloro-4-trifluoromethylphenl

Phenol, 2-chloro-4-(trifluoromethyl)-

3-chloro-4-hydroxytrifluoromethylene

2-chloro-4-(trifluoromethyl)phenol - [C86577]

35852-58-5

C7H4OClF3

Fluorine series

Phenol&Thiophenol&Mercaptan