PD 168077 MALEATE

Product Name: PD 168077 MALEATE
CAS No.: 630117-19-0
Chemical Name: PD 168077 MALEATE
Synonyms: PD 168077 (maL;PD 168077 MALEATE;PD-168077 maleate, 10 mM in DMSO;N-(METHYL-4-(2-CYANOPHENYL)PIPERAZINYL)-3-METHYLBENZAMIDE MALEATE;N-[[4-(2-CYANOPHENYL)-1-PIPERAZINYL]METHYL]-3-METHYL-BENZAMIDE MALEATE;Benzamide,N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-,(2Z)-2-butenedioate(1:1);PD 168077,Dopamine Receptor,PD-168077,inhibit,PD168077,PD168077 maleate,Inhibitor,PD 168077 maleate
CBNumber: CB6679671
Molecular Formula: C24H26N4O5
Formula Weight: 450.49
MOL File: Mol file

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PD 168077 MALEATE Property

storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: >10 mg/mL
form: powder
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.05878
Product name: PD 168077 Maleate - CAS 630117-19-0 - Calbiochem
Packaging: 10mg
Price: $201
Updated: 2024/03/01

Cayman Chemical

Product number: 29789
Product name: PD 168077 (maleate)
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29789
Product name: PD 168077 (maleate)
Packaging: 50mg
Price: $638
Updated: 2024/03/01

Cayman Chemical

Product number: 29789
Product name: PD 168077 (maleate)
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 29789
Product name: PD 168077 (maleate)
Packaging: 25mg
Price: $365
Updated: 2024/03/01

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PD 168077 MALEATE Chemical Properties,Usage,Production

Description

PD 168077 is a dopamine D₄ receptor agonist (K_i = 8.7 nM in CHO Pro 5 cells expressing the human receptor). It is selective for dopamine D₄ over D₂ and D₃ receptors (K_is = 3,740 and 2,810 nM, respectively), as well as α₁- and α₂-adrenergic and serotonin (5-HT) receptor subtypes 5-HT_1A and 5-HT_2A (K_is = 168, 177, 385, and 4,010 nM, respectively). PD 168077 (20 μM) induces CaMKII translocation from the dendritic shaft to postsynaptic sites on the dendritic processes of primary rat embryonic prefrontal cortex pyramidal neurons, an effect that can be blocked by the IP₃ receptor antagonist 2APB or the calcium chelator BAPTA AM . PD 168077 (50-200 ng/animal) induces penile erections in rats when injected into the paraventricular nucleus (PVN) of the hypothalamus. PD 168077 (0.2-25 mg/kg, s.c.) increases spontaneous locomotor activity and reduces grooming and rearing in rats.

Biological Activity

A potent D 4 dopamine receptor agonist (K i = 8.7 nM) with > 400-fold selectivity over D 2 and > 300-fold selectivity versus D 3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo .

storage

Store at -20°C

PD 168077 MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 168077 MALEATE Suppliers

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630117-19-0, PD 168077 MALEATERelated Search:

N-(METHYL-4-(2-CYANOPHENYL)PIPERAZINYL)-3-METHYLBENZAMIDE MALEATE

PD 168077 MALEATE

N-[[4-(2-CYANOPHENYL)-1-PIPERAZINYL]METHYL]-3-METHYL-BENZAMIDE MALEATE

PD 168077 (maL

Benzamide,N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-,(2Z)-2-butenedioate(1:1)

PD 168077,Dopamine Receptor,PD-168077,inhibit,PD168077,PD168077 maleate,Inhibitor,PD 168077 maleate

PD-168077 maleate, 10 mM in DMSO

630117-19-0

730117-19-0