ChemicalBook > CAS DataBase List > PD 168077 MALEATE

PD 168077 MALEATE

Product Name
PD 168077 MALEATE
CAS No.
630117-19-0
Chemical Name
PD 168077 MALEATE
Synonyms
PD 168077 (maL;PD 168077 MALEATE;PD-168077 maleate, 10 mM in DMSO;N-(METHYL-4-(2-CYANOPHENYL)PIPERAZINYL)-3-METHYLBENZAMIDE MALEATE;N-[[4-(2-CYANOPHENYL)-1-PIPERAZINYL]METHYL]-3-METHYL-BENZAMIDE MALEATE;Benzamide,N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-,(2Z)-2-butenedioate(1:1);PD 168077,Dopamine Receptor,PD-168077,inhibit,PD168077,PD168077 maleate,Inhibitor,PD 168077 maleate
CBNumber
CB6679671
Molecular Formula
C24H26N4O5
Formula Weight
450.49
MOL File
Mol file
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PD 168077 MALEATE Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: >10 mg/mL
form 
powder
color 
white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05878
Product name
PD 168077 Maleate - CAS 630117-19-0 - Calbiochem
Packaging
10mg
Price
$201
Updated
2024/03/01
Cayman Chemical
Product number
29789
Product name
PD 168077 (maleate)
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29789
Product name
PD 168077 (maleate)
Packaging
50mg
Price
$638
Updated
2024/03/01
Cayman Chemical
Product number
29789
Product name
PD 168077 (maleate)
Packaging
10mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
29789
Product name
PD 168077 (maleate)
Packaging
25mg
Price
$365
Updated
2024/03/01
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PD 168077 MALEATE Chemical Properties,Usage,Production

Description

PD 168077 is a dopamine D4 receptor agonist (Ki = 8.7 nM in CHO Pro 5 cells expressing the human receptor). It is selective for dopamine D4 over D2 and D3 receptors (Kis = 3,740 and 2,810 nM, respectively), as well as α1- and α2-adrenergic and serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A (Kis = 168, 177, 385, and 4,010 nM, respectively). PD 168077 (20 μM) induces CaMKII translocation from the dendritic shaft to postsynaptic sites on the dendritic processes of primary rat embryonic prefrontal cortex pyramidal neurons, an effect that can be blocked by the IP3 receptor antagonist 2APB or the calcium chelator BAPTA AM . PD 168077 (50-200 ng/animal) induces penile erections in rats when injected into the paraventricular nucleus (PVN) of the hypothalamus. PD 168077 (0.2-25 mg/kg, s.c.) increases spontaneous locomotor activity and reduces grooming and rearing in rats.

Biological Activity

A potent D 4 dopamine receptor agonist (K i = 8.7 nM) with > 400-fold selectivity over D 2 and > 300-fold selectivity versus D 3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo .

storage

Store at -20°C

PD 168077 MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 168077 MALEATE Suppliers

China 35 India 1 Japan 1 Switzerland 1 United Kingdom 2 United States 8 USA 1 Global 49
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9804
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
5960
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15818
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58

630117-19-0, PD 168077 MALEATERelated Search:


  • N-(METHYL-4-(2-CYANOPHENYL)PIPERAZINYL)-3-METHYLBENZAMIDE MALEATE
  • PD 168077 MALEATE
  • N-[[4-(2-CYANOPHENYL)-1-PIPERAZINYL]METHYL]-3-METHYL-BENZAMIDE MALEATE
  • PD 168077 (maL
  • Benzamide,N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-,(2Z)-2-butenedioate(1:1)
  • PD 168077,Dopamine Receptor,PD-168077,inhibit,PD168077,PD168077 maleate,Inhibitor,PD 168077 maleate
  • PD-168077 maleate, 10 mM in DMSO
  • 630117-19-0
  • 730117-19-0