ChemicalBook > CAS DataBase List > 3,5-Di-tert-butylbromobenzene

3,5-Di-tert-butylbromobenzene

Application

Product Name: 3,5-Di-tert-butylbromobenzene
CAS No.: 22385-77-9
Chemical Name: 3,5-Di-tert-butylbromobenzene
Synonyms: 1-BROMO-3,5-DI-TERT-BUTYLBENZENE;1-BROMO-3,5-DI-T-BUTYLBENZENE;TIMTEC-BB SBB005901;3,5- Di TERTbutylbenzene;1-Bromo-3,5-di-tert-butyL;3,5-DI-T-BUTYLBROMOBENZENE;3,5-Di-tert-butylbromobenze;3,5-Di-tert-butylbromobenzene;1-BroMo-3,5-di-tert-butybenzene;1,3-Di-tert-butyl-5-bromobenzene
CBNumber: CB6679949
Molecular Formula: C14H21Br
Formula Weight: 269.22
MOL File: 22385-77-9.mol

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3,5-Di-tert-butylbromobenzene Property

Melting point:: 62-66 °C(lit.)
Boiling point:: 152-156 °C(Press: 26 Torr)
Density: 1.126±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: White to Almost white
Water Solubility: 35μg/L at 25℃
BRN: 2091559
InChI: InChI=1S/C14H21Br/c1-13(2,3)10-7-11(14(4,5)6)9-12(15)8-10/h7-9H,1-6H3
InChIKey: BUOWTUULDKULFI-UHFFFAOYSA-N
SMILES: C1(Br)=CC(C(C)(C)C)=CC(C(C)(C)C)=C1
LogP: 6.7 at 25℃
CAS DataBase Reference: 22385-77-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 592161
Product name: 1-Bromo-3,5-di-tert-butylbenzene
Purity: 97%
Packaging: 1g
Price: $26.91
Updated: 2025/07/31

Sigma-Aldrich

Product number: 592161
Product name: 1-Bromo-3,5-di-tert-butylbenzene
Purity: 97%
Packaging: 10g
Price: $274
Updated: 2025/07/31

TCI Chemical

Product number: B3547
Product name: 1-Bromo-3,5-di-tert-butylbenzene
Packaging: 5G
Price: $95
Updated: 2025/07/31

TCI Chemical

Product number: B3547
Product name: 1-Bromo-3,5-di-tert-butylbenzene
Packaging: 25G
Price: $286
Updated: 2025/07/31

TRC

Product number: B689578
Product name: 1-Bromo-3,5-di-t-butylbenzene
Packaging: 500mg
Price: $65
Updated: 2021/12/16

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3,5-Di-tert-butylbromobenzene Chemical Properties,Usage,Production

Application

3,5-Di-tert-butylbromobenzene can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes.

Chemical Properties

White solid

Synthesis

1460-02-2

22385-77-9

General procedure for the synthesis of 3,5-di-tert-butylbromobenzene from 1,3,5-tri-tert-butylbenzene: In a dry and argon-flushed 250 mL three-necked round-bottomed flask, a condenser (with nitrogen inlet connector), a thermometer, a dosing funnel, and a magnetic stirring bar coated with Teflon were assembled. Under nitrogen protection, 1,3,5-tri-tert-butylbenzene (15.0 g, 61 mmol, 1.0 eq.) was dissolved in 42 mL of dichloromethane, stirred, and cooled to 0°C. The solution was then purged with an argon flushing syringe. 1.0 mL (7.8 mmol, 0.13 equiv) of antimony pentachloride (SbCl5) was added slowly using an argon-flushed syringe. Liquid bromine (4.94 mL, 96.0 mmol, 1.6 equiv) was dissolved in 20 mL of dichloromethane and transferred to the addition funnel. The entire apparatus was wrapped in aluminum foil to protect it from light. The bromine solution was slowly added dropwise (approximately 1 drop every 2 seconds) over a period of 2 hours. After the dropwise addition, stirring was continued for 3 hours at 0°C. The reaction solution was poured into a mixture of 800 g of ice and 800 mL of water and stirred for 15 minutes. Adjust to pH 8-9 by slowly adding 100 mL of 5 M aqueous sodium hydroxide under stirring. extract the aqueous phase with dichloromethane three times using a 2 L partition funnel. The organic phases were combined and washed sequentially with water, saturated aqueous sodium thiosulfate, water and brine and dried over anhydrous magnesium sulfate. Concentrated by rotary evaporation and dried under vacuum for several hours. The crude product was recrystallized from 30 mL of hot ethanol, heated to boiling and then cooled to room temperature, the solid was collected by filtration and washed three times with minimal amounts of cold ethanol. Vacuum drying gave 11.1 g (68% yield) of 1-bromo-3,5-di-tert-butylbenzene.1H NMR (500 MHz, CDCl3): δ 1.30 (s, 18H), 7.17 (d, 1H), 7.32 (s, 2H). The analytical data are in agreement with literature reports.

References

[1] Chemistry - A European Journal, 2007, vol. 13, # 16, p. 4433 - 4451
[2] Synthetic Communications, 1996, vol. 26, # 9, p. 1693 - 1697
[3] Synlett, 2017, vol. 28, # 13, p. 1548 - 1553
[4] Organic Letters, 2005, vol. 7, # 24, p. 5365 - 5368
[5] Macromolecules, 2002, vol. 35, # 14, p. 5382 - 5387

3,5-Di-tert-butylbromobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Di-tert-butylbromobenzene manufacturers

Zhejiang Free Trade Zone Violet Trade Co., Ltd.

Product: 3,5-Di-tert-butylbromobenzene 22385-77-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.9% HPLC
Supply Ability: 10 tons
Release date: 2024-03-18

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,5-Di-tert-butylbromobenzene 22385-77-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Henan Aochuang Chemical Co.,Ltd.

Product: 3,5-Di-tert-butylbromobenzene 22385-77-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

22385-77-9, 3,5-Di-tert-butylbromobenzeneRelated Search:

1-Bromo-4-tert-butylbenzene 1,3-Dibromobenzene tert-Butanol Butylated Hydroxytoluene 5-Bromo-m-xylene Di-tert-butyl peroxide Bromoxynil Bromine Butylbenzene THIOGLYCOLIC ACID N-BUTYL ESTER 2-BROMO-4,6-DI-TERT-BUTYLPHENOL 4-Bromo-2,6-di-tert-butylphenol 4,5-DIBROMO-2,7-DI-TERT-BUTYL-9,9-DIMETHYLXANTHENE Recombinant Human Telomerase 3,5-Di-tert-butylbromobenzene 1-BROMO-3,5-DITERT-BUTYL-2-NITROBENZENE

TIMTEC-BB SBB005901

1-BROMO-3,5-DI-TERT-BUTYLBENZENE

1-BROMO-3,5-DI-T-BUTYLBENZENE

3,5-DI-T-BUTYLBROMOBENZENE

1-Bromo-3,5-di-tert-butyL

3,5-Di-tert-butylbromobenzene

3,5-Di-tert-butylbromobenze

1-BROMO-3,5-DI-TERT-BUTYLBENZENE 99%

1,3-Di-tert-butyl-5-bromobenzene

1-Bromo-3,5-di(tert-butyyl)benzene

5-BroMo-1,3-di-tert-butylbenzene

1-BroMo-3,5-di-tert-butybenzene

1,3-Bis(tert-butyl)-5-bromobenzene

3,5- Di TERTbutylbenzene

1-Bromo-3,5-di-<i>tert</i>-butylbenzene

1-Bromo-3,5-di-tert-butylbenzene≥ 99%(GC)

Benzene,1-bromo-3,5-bis(1,1-dimethylethyl)-

1-Bromo-3,5-di-tert-butylbenzene, 99% white crystalline solid

1-bromo-3,5-di-tert-butylbenzene, 3,5-di-tert-Bu-bromobenzene, 3,5-tert-butyl bromobenzene, bromo-3,5-di-t-butylbenzene, 1-bromo-3,5-di(tert-butyl)benzene, 1-bromo-3,5-di-tert-butyl benzene, 3,5-di-tert-butyl-1-bromobenzene

5-Bromo-1,3-di-tert-butylbenzene/1-Bromo-3,5-di-tert-butylbenzene

3,5-Bis(tert-butyl)-1-bromo-benzene

1-Bromo-3,5-di-tert-butylbenzene &gt

3,5-Di-tert-butylbromobenzene ISO 9001：2015 REACH

3, 5-Di-Tert-Butylbromobenzene CAS 22385-77-9

1-Bromo-3,5-bis(1,1-dimethylethyl)benzene

3,5-Di-tert-butylbromobenzene 98+

22385-77-9

BrC6H3CCH332

ARYL HALIDE

Organic Building Blocks

Halogenated Hydrocarbons

Building Blocks

C13 to C37+

Aryl

C13 to C37+

Halogenated Hydrocarbons