12(S)-HPEPE

Product Name: 12(S)-HPEPE
CAS No.: 103239-14-1
Chemical Name: 12(S)-HPEPE
Synonyms: 12(S)-HPEPE;HDMYXONNVAOHFR-UOLHMMFFSA-N;12(S)-HpEPE(solution in ethanol);12(S)-hydroperoxy-5(Z),8(Z),10(E),14(Z),17(Z)-EPA;12S-HYDROPEROXY-5Z,8Z,10E,14Z,17Z-EICOSAPENTAENOIC ACID;5,8,10,14,17-Eicosapentaenoic acid, 12-hydroperoxy-, (5Z,8Z,10E,12S,14Z,17Z)-
CBNumber: CB6687498
Molecular Formula: C20H30O4
Formula Weight: 334.45
MOL File: 103239-14-1.mol

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12(S)-HPEPE Property

storage temp.: Store at -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 42550
Product name: 12(S)-HpEPE
Purity: ≥96%
Packaging: 25μg
Price: $201
Updated: 2024/03/01

Cayman Chemical

Product number: 42550
Product name: 12(S)-HpEPE
Purity: ≥96%
Packaging: 50μg
Price: $362
Updated: 2024/03/01

Cayman Chemical

Product number: 42550
Product name: 12(S)-HpEPE
Purity: ≥96%
Packaging: 100μg
Price: $642
Updated: 2024/03/01

AHH

Product number: MT-14825
Product name: 12(S)-Hpepe
Purity: 98%
Packaging: 0.0001g
Price: $410
Updated: 2021/12/16

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12(S)-HPEPE Chemical Properties,Usage,Production

Description

12(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 12-lipoxygenase on eicosapentaenoic acid. Although the biological activities of 12(S)-HpEPE have not been well characterized, it is expected to behave similarly to 12(S)-HpETE (Catalog No. 44570).

Uses

12(S)-HPEPE is a lipoxygenase product and an intermediate metabolite that leads to downregulation of PGHS-2 and has potential anti-inflammatory activity. 12(S)-HPEPE reduces interleukin 1h (IL-1h)-induced PGHS-2 expression in human lung microvascular endothelial cells[1].

Definition

ChEBI: 12(S)-HpEPE is a 12-HPEPE in which the hydroperoxy group at positions 12 has S-configuration. It has a role as a human xenobiotic metabolite. It is a conjugate acid of a 12(S)-HpEPE(1-).

References

[1] Ait-Said F, et al. Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. Biochim Biophys Acta. 2003 Feb 20;1631(1):77-84. DOI:10.1016/s1388-1981(02)00358-x

12(S)-HPEPE Preparation Products And Raw materials

Raw materials

Preparation Products

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12(S)-HPEPE Suppliers

China 32 Switzerland 1 United Kingdom 1 United States 3 Global 37

AXXORA, LLC

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Email: alexis-ch@alexis-corp.com
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103239-14-1, 12(S)-HPEPERelated Search:

(Z,Z)-3,6-NONADIEN-1-OL 12(S)-HPEPE 12(S)-HEPE (+/-)-12-HYDROXY-5Z,8Z,10E,14Z,17Z-EICOSAPENTAENOIC ACID

12(S)-HPEPE

12S-HYDROPEROXY-5Z,8Z,10E,14Z,17Z-EICOSAPENTAENOIC ACID

HDMYXONNVAOHFR-UOLHMMFFSA-N

5,8,10,14,17-Eicosapentaenoic acid, 12-hydroperoxy-, (5Z,8Z,10E,12S,14Z,17Z)-

12(S)-hydroperoxy-5(Z),8(Z),10(E),14(Z),17(Z)-EPA

12(S)-HpEPE(solution in ethanol)

103239-14-1