Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN

Product Name: Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN
CAS No.: 156192-32-4
Chemical Name: Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN
Synonyms: Z-LEU-ARG-AMC;Z-LEU-ARG-AMC HYDROCHLORIDE;Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN;CBZ-Leu-Arg-AMC hydrochloride salt;Benzyloxycarbonyl-L-leucyl-L-arginine 4-methylcoumaryl-7-amide;L-Argininamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
CBNumber: CB6691323
Molecular Formula: C30H38N6O6
Formula Weight: 578.66
MOL File: 156192-32-4.mol

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Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at 0-5°C
solubility: Soluble in DMSO
form: solid
pka: 11.13±0.46(Predicted)
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. Protect from light!

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J64082
Product name: Cathepsin K Substrate (fluorogenic)
Packaging: 10mg
Price: $140
Updated: 2023/06/20

Alfa Aesar

Product number: J64082
Product name: Cathepsin K Substrate (fluorogenic)
Packaging: 25mg
Price: $307
Updated: 2023/06/20

Chem-Impex

Product number: 04695
Product name: Z-Leu-Arg-AMC·HCl,99%
Purity: 99%
Packaging: 5G
Price: $512.51
Updated: 2021/12/16

Chem-Impex

Product number: 04695
Product name: Z-Leu-Arg-AMC·HCl,99%
Purity: 99%
Packaging: 250MG
Price: $908.54
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0009299
Product name: Z-LEU-ARG-AMC-HYDROCHLORIDE
Purity: 99.00%
Packaging: 0.1G
Price: $1540
Updated: 2021/12/16

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Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Chemical Properties,Usage,Production

Description

Z-Leu-Arg-AMC (156192-32-4) is a sensitive Cathepsin K fluorogenic substrate (Km=8μM, kcat/Km=4 x 105 M-1s-1)1-3. It is cleaved more slowly by the following cathepsins (kcat/Km: B (105)4, F (106)4, L (106)4,5, L2/V (104)5, S (105)2,4,5. Also cleaved by malaria parasite proteases berghepain6, vivapain-2 and -37, and falcipain-1, -2, and -36,8,9. Excitation: 365nm, Emission: 440nm.

Uses

A sensitive fluorogenic substrate for cathepsin K

References

Bossard et al. (1996), Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification; J. Biol. Chem. 271 12517 Br?mme et al. (1996), Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme; J. Biol. Chem. 271 2126 Linnevers et al. (1997), Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex; Protein Sci. 6 919 Wang et al. (1998), Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization; J. Biol. Chem., 273 32000 Br?mme et al. (1999), Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization and chromosomal localization; Biochemistry, 38 2377 Singh et al. (2007), A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2; Protein Eng. Des. Sel. 20 171 Na et al. (2004), Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax; Biochem. J. 378(Pt2) 529 Goh et al. (2005), Cysteine protease falcipain 1 in Plasmodium falciparum is biochemically distinct from its isozymes; Parasitol. Res. 97 295 Pandey et al. (2004), Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2; J. Biol. Chem. 279 3484

Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Suppliers

China 28 United States 4 Global 32

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-025-58361106-805-805 13082558573
Fax: 025-58361106-806
Email: liugang@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 6756
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Nanchang Tianzhen Biotechnology Co., Ltd

Tel: 13173652190
Email: pomy@tanzhenbio.com
Country: China
ProdList: 1775
Advantage: 58

Nanjing TGpeptide Biotechnology Co.,Ltd.

Tel: 18115476705
Email: sales@tgpeptide.com
Country: China
ProdList: 3058
Advantage: 58

DONBOO AMINO ACID COMPANY

Tel: +8613063595538
Email: donboo@donboo.com
Country: China
ProdList: 9363
Advantage: 58

156192-32-4, Z-LEU-ARG-7-AMINO-4-METHYLCOUMARINRelated Search:

Z-LEU-SER-OME Z-HIS-ALA-OH Z-LEU-LEU-OH BENZYLOXYCARBONYL-L-LEUCYL-L-ARGINYLGLYCYLGLYCINE 4-METHYLCOUMARYL-7-AMIDE Z-HIS-TRP-OH Z-ILE-VAL-OH Z-HIS-4-NITRO-PHE-PHE-OME Z-HIS-PHE-TRP-OET Z-LEU-GLY-OME Z-HIS-VAL-OH Z-LEU-MET-OH Z-LEU-TYR-NH2 Z-LYS(BOC)-LEU-OME Z-LLL-AMC Z-LEU-LEU-GLU-AMC Z-LEU-LEU-ARG-AMC Boc-Cha-OH·xH2O H-ALA-ARG-AMC HCL

Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN

Z-LEU-ARG-AMC

Z-LEU-ARG-AMC HYDROCHLORIDE

L-Argininamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Benzyloxycarbonyl-L-leucyl-L-arginine 4-methylcoumaryl-7-amide

CBZ-Leu-Arg-AMC hydrochloride salt

156192-32-4

C30H38N6O6