Z-LEU-LEU-GLU-AMC

Product Name: Z-LEU-LEU-GLU-AMC
CAS No.: 348086-66-8
Chemical Name: Z-LEU-LEU-GLU-AMC
Synonyms: Z-ILE-AMC;Z-LLE-AMC;Z-LLG-AMC;Z-LEU-LEU-GLU-MCA;Z-LEU-LEU-GLU-AMC;Z-LEU-LEU-GLY-AMC;CBZ-LEU-LEU-GLU-AMC;Proteasome Substrate II;Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC;PROTEASOME SUBSTRATE II (FLUOROGENIC)
CBNumber: CB6298942
Molecular Formula: C35H44N4O9
Formula Weight: 664.75
MOL File: 348086-66-8.mol

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Z-LEU-LEU-GLU-AMC Property

Boiling point:: 967.8±65.0 °C(Predicted)
Density: 1.253±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble
form: solid
pka: 4.43±0.10(Predicted)
color: Solid lyophilized powder

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C0483
Product name: Z-Leu-Leu-Glu-7-amido-4-methylcoumarin
Purity: ≥95%, solid
Packaging: 5MG
Price: $404
Updated: 2023/06/20

Alfa Aesar

Product number: J64613
Product name: Z-Leu-Leu-Glu-7-amino-4-methylcoumarin
Packaging: 5mg
Price: $141
Updated: 2023/06/20

Cayman Chemical

Product number: 10008117
Product name: Z-LLE-AMC
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10008117
Product name: Z-LLE-AMC
Purity: ≥95%
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 10008117
Product name: Z-LLE-AMC
Purity: ≥95%
Packaging: 10mg
Price: $235
Updated: 2024/03/01

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Z-LEU-LEU-GLU-AMC Chemical Properties,Usage,Production

Description

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.

Uses

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.

Uses

A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole

General Description

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.

Biochem/physiol Actions

Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.

storage

+4°C

Z-LEU-LEU-GLU-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-LEU-LEU-GLU-AMC Suppliers

China 65 India 1 Japan 1 Switzerland 2 United Kingdom 3 United States 12 Global 84

VDM Biochemicals

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ShenZhen InnoSyn Biotech Co.,Ltd

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Sigma-Aldrich

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Shenzhen Chim Biotech Co., Ltd.

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Creative Peptides

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Shanghai Chaolan Chemical Technology Center

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348086-66-8, Z-LEU-LEU-GLU-AMCRelated Search:

Z-LEU-LEU-ARG-AMC Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Z-LEU-LEU-OH Z-LLL-AMC BENZYLOXYCARBONYL-L-LEUCYL-L-ARGINYLGLYCYLGLYCINE 4-METHYLCOUMARYL-7-AMIDE H-GLU(AMC)-OH MG-115 Z-LEU-LEU-GLU-AMC Z-LEU-LEU-GLU-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN GLUTAMIC ACID(ANILIDE)-OH

CBZ-LEU-LEU-GLU-AMC

CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-GLUTAMIC-ACID-ALPHA-(4-METHYLCOUMARINYL)-7-AMIDE

BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-GLUTAMIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE)

PROTEASOME SUBSTRATE II (FLUOROGENIC)

Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN

Z-LEU-LEU-GLU-7-AMINO-4-METHYLCOUMARIN

Z-LEU-LEU-GLU-AMC

Z-LEU-LEU-GLU-MCA

Z-LLE-AMC

Z-ILE-AMC

N-[(Phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alpha-glutamine

Z-LLG-AMC

(5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid

Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC

Z-LEU-LEU-GLY-AMC

benzyloxycarbonyl-L-leucyl-L-leucyl-L-glutamic acid α-(4-methylcoumaryl-7-amide)

Proteasome Substrate II

L-α-Glutamine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

348086-66-8

C35H44N4O9

Proteasome substrate II.