ChemicalBook > CAS DataBase List > Z-LEU-LEU-GLU-AMC

Z-LEU-LEU-GLU-AMC

Product Name
Z-LEU-LEU-GLU-AMC
CAS No.
348086-66-8
Chemical Name
Z-LEU-LEU-GLU-AMC
Synonyms
Z-ILE-AMC;Z-LLE-AMC;Z-LLG-AMC;Z-LEU-LEU-GLU-MCA;Z-LEU-LEU-GLU-AMC;Z-LEU-LEU-GLY-AMC;CBZ-LEU-LEU-GLU-AMC;Proteasome Substrate II;Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC;PROTEASOME SUBSTRATE II (FLUOROGENIC)
CBNumber
CB6298942
Molecular Formula
C35H44N4O9
Formula Weight
664.75
MOL File
348086-66-8.mol
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Z-LEU-LEU-GLU-AMC Property

Boiling point:
967.8±65.0 °C(Predicted)
Density 
1.253±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
solid
pka
4.43±0.10(Predicted)
color 
Solid lyophilized powder
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0483
Product name
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin
Purity
≥95%, solid
Packaging
5MG
Price
$404
Updated
2023/06/20
Alfa Aesar
Product number
J64613
Product name
Z-Leu-Leu-Glu-7-amino-4-methylcoumarin
Packaging
5mg
Price
$141
Updated
2023/06/20
Cayman Chemical
Product number
10008117
Product name
Z-LLE-AMC
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
10008117
Product name
Z-LLE-AMC
Purity
≥95%
Packaging
5mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
10008117
Product name
Z-LLE-AMC
Purity
≥95%
Packaging
10mg
Price
$235
Updated
2024/03/01
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Z-LEU-LEU-GLU-AMC Chemical Properties,Usage,Production

Description

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.

Uses

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.

Uses

A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole

General Description

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.

Biochem/physiol Actions

Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.

storage

+4°C

Z-LEU-LEU-GLU-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

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348086-66-8, Z-LEU-LEU-GLU-AMCRelated Search:


  • CBZ-LEU-LEU-GLU-AMC
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-GLUTAMIC-ACID-ALPHA-(4-METHYLCOUMARINYL)-7-AMIDE
  • BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-GLUTAMIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE)
  • PROTEASOME SUBSTRATE II (FLUOROGENIC)
  • Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN
  • Z-LEU-LEU-GLU-7-AMINO-4-METHYLCOUMARIN
  • Z-LEU-LEU-GLU-AMC
  • Z-LEU-LEU-GLU-MCA
  • Z-LLE-AMC
  • Z-ILE-AMC
  • N-[(Phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alpha-glutamine
  • Z-LLG-AMC
  • (5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid
  • Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC
  • Z-LEU-LEU-GLY-AMC
  • benzyloxycarbonyl-L-leucyl-L-leucyl-L-glutamic acid α-(4-methylcoumaryl-7-amide)
  • Proteasome Substrate II
  • L-α-Glutamine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • 348086-66-8
  • C35H44N4O9
  • Proteasome substrate II.