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Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN

Product Name
Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN
CAS No.
156192-32-4
Chemical Name
Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN
Synonyms
Z-LEU-ARG-AMC;Z-LEU-ARG-AMC HYDROCHLORIDE;Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN;CBZ-Leu-Arg-AMC hydrochloride salt;Benzyloxycarbonyl-L-leucyl-L-arginine 4-methylcoumaryl-7-amide;L-Argininamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
CBNumber
CB6691323
Molecular Formula
C30H38N6O6
Formula Weight
578.66
MOL File
156192-32-4.mol
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Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Property

Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at 0-5°C
solubility 
Soluble in DMSO
form 
solid
pka
11.13±0.46(Predicted)
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. Protect from light!
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64082
Product name
Cathepsin K Substrate (fluorogenic)
Packaging
10mg
Price
$140
Updated
2023/06/20
Alfa Aesar
Product number
J64082
Product name
Cathepsin K Substrate (fluorogenic)
Packaging
25mg
Price
$307
Updated
2023/06/20
Chem-Impex
Product number
04695
Product name
Z-Leu-Arg-AMC·HCl,99%
Purity
99%
Packaging
5G
Price
$512.51
Updated
2021/12/16
Chem-Impex
Product number
04695
Product name
Z-Leu-Arg-AMC·HCl,99%
Purity
99%
Packaging
250MG
Price
$908.54
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0009299
Product name
Z-LEU-ARG-AMC-HYDROCHLORIDE
Purity
99.00%
Packaging
0.1G
Price
$1540
Updated
2021/12/16
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Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Chemical Properties,Usage,Production

Description

Z-Leu-Arg-AMC (156192-32-4) is a sensitive Cathepsin K fluorogenic substrate (Km=8μM, kcat/Km=4 x 105 M-1s-1)1-3. It is cleaved more slowly by the following cathepsins (kcat/Km: B (105)4, F (106)4, L (106)4,5, L2/V (104)5, S (105)2,4,5. Also cleaved by malaria parasite proteases berghepain6, vivapain-2 and -37, and falcipain-1, -2, and -36,8,9. Excitation: 365nm, Emission: 440nm.

Uses

A sensitive fluorogenic substrate for cathepsin K

References

Bossard et al. (1996), Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification; J. Biol. Chem. 271 12517 Br?mme et al. (1996), Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme; J. Biol. Chem. 271 2126 Linnevers et al. (1997), Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex; Protein Sci. 6 919 Wang et al. (1998), Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization; J. Biol. Chem., 273 32000 Br?mme et al. (1999), Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization and chromosomal localization; Biochemistry, 38 2377 Singh et al. (2007), A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2; Protein Eng. Des. Sel. 20 171 Na et al. (2004), Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax; Biochem. J. 378(Pt2) 529 Goh et al. (2005), Cysteine protease falcipain 1 in Plasmodium falciparum is biochemically distinct from its isozymes; Parasitol. Res. 97 295 Pandey et al. (2004), Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2; J. Biol. Chem. 279 3484

Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN Suppliers

China 29 United States 4 Global 33
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Chem-Impex International, Inc.
Tel
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Fax
--
Country
United States
ProdList
6730
Advantage
64
3B Scientific Corporation
Tel
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Fax
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Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
MP Biomedicals, Inc.
Tel
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Fax
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Country
United States
ProdList
6561
Advantage
81

156192-32-4, Z-LEU-ARG-7-AMINO-4-METHYLCOUMARINRelated Search:

Z-LEU-SER-OME Z-HIS-ALA-OH Z-LEU-LEU-OH BENZYLOXYCARBONYL-L-LEUCYL-L-ARGINYLGLYCYLGLYCINE 4-METHYLCOUMARYL-7-AMIDE Z-HIS-TRP-OH Z-ILE-VAL-OH Z-HIS-4-NITRO-PHE-PHE-OME Z-HIS-PHE-TRP-OET Z-LEU-GLY-OME Z-HIS-VAL-OH Z-LEU-MET-OH Z-LEU-TYR-NH2 Z-LYS(BOC)-LEU-OME Z-LLL-AMC Z-LEU-LEU-GLU-AMC Z-LEU-LEU-ARG-AMC Boc-Cha-OH·xH2O H-ALA-ARG-AMC HCL

  • Z-LEU-ARG-7-AMINO-4-METHYLCOUMARIN
  • Z-LEU-ARG-AMC
  • Z-LEU-ARG-AMC HYDROCHLORIDE
  • L-Argininamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • Benzyloxycarbonyl-L-leucyl-L-arginine 4-methylcoumaryl-7-amide
  • CBZ-Leu-Arg-AMC hydrochloride salt
  • 156192-32-4
  • C30H38N6O6