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POLYDIMETHYLSILOXANE

Product Name
POLYDIMETHYLSILOXANE
CAS No.
8050-81-5
Chemical Name
POLYDIMETHYLSILOXANE
Synonyms
SILICONE FLUID;POLYMETHYLSILOXANE;DIMETHYL SILICONE;Sentry SiMethicone GS;POLYDIMETHYLSILOXAN;ANTIFOAM B EMULSION;ANTIFOAM A CONCENTRATE;phazyMe;ANTIFOAM AF;VISCOSITY STANDARD
CBNumber
CB6696474
Molecular Formula
(C2H6OSi)n
Formula Weight
0
MOL File
8050-81-5.mol
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POLYDIMETHYLSILOXANE Property

Density 
1 g/mL at 20 °C
vapor pressure 
5 mm Hg ( 20 °C)
refractive index 
n20/D 1.406
Flash point:
>101°C
storage temp. 
room temp
solubility 
Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene.
form 
emulsion
color 
Colorless
LogP
3.404 (est)
EPA Substance Registry System
Simethicone (8050-81-5)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37-20-62
Safety Statements 
26-36-23-36/37
WGK Germany 
3
RTECS 
TQ2690000
HS Code 
3910000000
Hazardous Substances Data
8050-81-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8011
Product name
Antifoam C Emulsion
Purity
aqueous-silicone emulsion
Packaging
250ml
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
A5633
Product name
Antifoam A Concentrate
Purity
active silicone polymer 100?%
Packaging
25G
Price
$62.4
Updated
2024/03/01
Sigma-Aldrich
Product number
A6582
Product name
Antifoam A concentrate
Purity
active silicone polymer 100%
Packaging
100g
Price
$91.4
Updated
2024/03/01
Sigma-Aldrich
Product number
A5633
Product name
Antifoam A Concentrate
Purity
active silicone polymer 100?%
Packaging
100G
Price
$125
Updated
2024/03/01
Sigma-Aldrich
Product number
1612652
Product name
Simethicone
Packaging
50g
Price
$483
Updated
2024/03/01
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POLYDIMETHYLSILOXANE Chemical Properties,Usage,Production

Chemical Properties

Viscous, greyish-white, opalescent liquid.

Chemical Properties

The PhEur 6.0 and USP 32 describe simethicone as a mixture of fully methylated linear siloxane polymers containing repeating units of the formula [–(CH3)2SiO–]n, stabilized with trimethylsiloxy endblocking units of the formula [(CH3)3 SiO–], and silicon dioxide. It contains not less than 90.5% and not more than 99.0% of the polydimethylsiloxane [–(CH3)2SiO–]n, and not less than 4.0% and not more than 7.0% of silicon dioxide. The PhEur 6.0 additionally states that the degree of polymerization is between 20–400.
Simethicone occurs as a translucent, gray-colored, viscous fluid. It has a molecular weight of 14 000–21 000.

Originator

Mylicon,Stuart,U.S.,1960

Uses

Antifoam A Concentrate has been used as a component of Luria Bertani culture medium for growth of BL21 (DE3) E. coli cells transformed with the plasmids. It has also been used as a constituent in the preparation of aerosol generation fluid.

Uses

Simethicone is an oral anti-foaming agent used to reduce bloating, discomfort and pain caused by excess gas in the stomach or intestinal tract. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel.

Uses

Simethicone Emulsion USP is a water dilutable, non-ionic emulsion containing 30% Simethicone USP by weight. Highly stable over a broad pH range. Simethicones are used as anti foam agents in the manufacture of drugs. Their use in Pharmaceuticals is to comb

Production Methods

Silicon dioxide is initially rendered hydrophobic in one of a variety of proprietary processes specific to a particular manufacturer. It is then slowly mixed with the silicone fluids in a formulation. After mixing, the simethicone is milled to ensure uniformity.

Manufacturing Process

In a 5 liter three-necked flask, fitted with a reflux condenser, agitator and thermometer, were placed 1,393 g (9.41 mold) of redistilled (CH3)2Si(OEt)2 and 1,110 g (9.41 mols) of (CH3)3SiOEt. To this solution was added 254 g (14.11 mols) of water containing 7.5 g of NaOH (approximately 1 NaOH per 100 silicon atoms). This insured the formation of only straight chain polymers. The mixture was heated to 40°C and the temperature continued to rise for nearly an hour. After adding 50 cc (20% excess) more water, the mixture was refluxed for two hours and then allowed to stand overnight.
Alcohol was then distilled off, until the temperature reached 100°C. 1,706.6 g of distillate was collected. (Theory 1,430 g.) This alcohol was poured into four times its volume of water and an insoluble oil separated (457 g). The insoluble fraction was added back to the copolymer residue from the distillation and 555 cc of 20% hydrochloric acid was added. The acid mixture was refluxed for two hours, and the silicon oils were carefully washed with distilled water until neutral. The yield was 1,420 g. (Theory 1,409 g.)

brand name

Gas-X (Novartis); Mylanta Gas Relief (Johnson & Johnson-Merck Consumer); Mylicon Infant’s Drops (Johnson & Johnson-Merck Consumer); Sentry Simethicone (Witco); Sentry Simethicone Emulsion (Witco).

Therapeutic Function

Antiflatulent

General Description

Antifoam A Concentrate is an extremely effective foam suppressor for aqueous and non-aqueous systems. It is 100% active silicone polymer. No emulsifiers are present. Antifoam A Concentrate is typically effective at 1-100 ppm. Antifoam A Concentrate should be diluted with 3-10 parts of propylene glycol (aqueous) or vegetable oil (nonaqueous) with slow mixing. The product will be stable in the pH range of 5 to 9. Antifoam A Concentrate can be added directly to a fermentation medium, but it is not recommended that it be pumped to a fermenter on an as-needed basis.

Pharmaceutical Applications

The main use of simethicone as an excipient is as an antifoaming agent in pharmaceutical manufacturing processes, for which 1–50 ppm is used.
Therapeutically, simethicone is included in a number of oral pharmaceutical formulations as an antiflatulent, although its therapeutic benefit is questionable. It is also included in antacid products such as tablets or capsules. In some types of surgical or gastroscopic procedures where gas is used to inflate the body cavity, a defoaming preparation containing simethicone may be used in the area to control foaming of the fluids.
When simethicone is used in aqueous formulations, it should be emulsified to ensure compatibility with the aqueous system and components.
In the USA, up to 10 ppm of simethicone may be used in food products.

Safety

Simethicone is used in cosmetics, foods, and oral and topical pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient. Direct contact with the eye may cause irritation.
Therapeutically, oral doses of 125–250mg of simethicone, three or four times daily, have been given as an antiflatulent. Doses of 20–40 mg of simethicone have been given with feeds to relieve colic in infants.
LD50 (dog, IV): 0.9 g/kg

storage

Simethicone is generally regarded as a stable material when stored in the original unopened container. A shelf-life of 18 months from the date of manufacture is typical. However, some simethicone products have a tendency for the silicon dioxide to settle slightly and containers of simethicone should therefore be shaken thoroughly to ensure uniformity of contents before sampling or use. Simethicone should be stored in a cool, dry, location away from oxidizing materials.
Simethicone can be sterilized by dry heating or autoclaving. With dry heating, a minimum of 4 hours at 160℃ is required.

Incompatibilities

Simethicone as supplied is not generally compatible with aqueous systems and will float like an oil on a formulation unless it is first emulsified. It should not be used in formulations or processing conditions that are very acidic (below pH 3) or highly alkaline (above pH 10), since these conditions may have some tendency to break the polydimethylsiloxane polymer. Simethicone cannot normally be mixed with polar solvents of any kind because it is very minimally soluble. Simethicone is incompatible with oxidizing agents.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (oral emulsions, powders, solutions, suspensions, tablets; and rectal and topical preparations). Included in nonparenteral medicines licensed in the UK.

POLYDIMETHYLSILOXANE Preparation Products And Raw materials

Raw materials

Preparation Products

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POLYDIMETHYLSILOXANE Suppliers

Sinfachem Limited.
Tel
025-84683399 13952017251
Email
sinfachem@foxmail.com
Country
China
ProdList
308
Advantage
58
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18736
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
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View Lastest Price from POLYDIMETHYLSILOXANE manufacturers

Hebei Duling International Trade Co. LTD
Product
POLYDIMETHYLSILOXANE 8050-81-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-03-27
Hebei Yanxi Chemical Co., Ltd.
Product
POLYDIMETHYLSILOXANE 8050-81-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-10
Shanghai Chinqesen Biotechnology Co., Ltd.
Product
POLYDIMETHYLSILOXANE 8050-81-5
Price
US $30.00-20.00/BOX
Min. Order
10BOX
Purity
99
Supply Ability
20TONS
Release date
2023-11-08

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