ChemicalBook > CAS DataBase List > POBN

POBN

Product Name: POBN
CAS No.: 66893-81-0
Chemical Name: POBN
Synonyms: POBN;Butylpyridyloxidenitrone;-(4-pyridyl-1-oxide)nitrone;PYRIDYLOXIDE t-BUTYLNITRONE;N-tert-Butyl-α4-Pyridyl-1-oxide-tert-butyl Nitrone;A-(4-PYRIDYL-N-OXIDE-N-TERT-BUTYLNITRONE;N-TERT-BUTYL-A-(4-PYRIDYL)NITRONEN-OXIDE;N-tert-Butyl-α-(4-pyridyl-1-oxide)nitrone;α-(4-pyridyl n-oxide)-n-tert-butylnitrone
CBNumber: CB6702751
Molecular Formula: C10H14N2O2
Formula Weight: 194.23
MOL File: 66893-81-0.mol

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POBN Property

Melting point:: 183-185 °C(lit.)
Boiling point:: 330.68°C (rough estimate)
Density: 1.1444 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: room temp
solubility: water: soluble10mg/mL, clear, colorless to faintly yellow
form: White to off-white or colorless crystalline solid.
pka: 0.76±0.53(Predicted)
color: White to Light yellow
Water Solubility: water: soluble 10mg/mL, clear, colorless to faintly yellow
BRN: 1453764

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 215430
Product name: α-(4-Pyridyl N-oxide)-N-tert-butylnitrone
Purity: 99%
Packaging: 1g
Price: $644
Updated: 2025/07/31

Sigma-Aldrich

Product number: P9271
Product name: α-(4-Pyridyl N-oxide)-N-tert-butylnitrone
Purity: ~95%
Packaging: 1g
Price: $62
Updated: 2023/06/20

TCI Chemical

Product number: B1735
Product name: N-tert-Butyl-alpha-(4-pyridyl-1-oxide)nitrone
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $224
Updated: 2025/07/31

TCI Chemical

Product number: B1735
Product name: N-tert-Butyl-alpha-(4-pyridyl-1-oxide)nitrone
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $673
Updated: 2025/07/31

Cayman Chemical

Product number: 20623
Product name: POBN
Purity: ≥98%
Packaging: 100mg
Price: $40
Updated: 2024/03/01

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POBN Chemical Properties,Usage,Production

Chemical Properties

white to pale yellow crystalline powder

Uses

Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.

Uses

POBN is a cell permeable hydrophilic spin trap for in vitro studies. It is a water soluble analog of PBN with low paramagnetic impurities and does not require any further purification. POBN has also also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide.

in vivo

Electron spin resonance (ESR) spectrum of radical adducts detected in bile of rats 1 h after acute Sodium formate (2 g/kg) and POBN (1.5 g/kg) i.p. administration^[1].

Animal Model:	Fischer male rats (300-400 g)^[1]
Dosage:	1.5 g/kg (Pharmacokinetic Analysis)
Administration:	Injected simultaneously i.p.
Result:	A strong six-line ESR signal of the POBN radical adduct was detected in the bile of rats after acute sodium formate poisoning.

POBN Preparation Products And Raw materials

Raw materials

Preparation Products

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POBN Suppliers

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66893-81-0, POBNRelated Search:

1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine 4,4'-DIPYRIDYL DISULFIDE 4-Picoline-N-oxide 4-Pyridinealdoxime isonicotinaldehyde oxime 1-oxide POBN

α-(4-Pyridyl N-oxide)-N-tert-butylnitrone,N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide, N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide, POBN

alpha-(4-Pyridyl 1-oxide)-N-tert-butyl-nitrone, 99% 100MG

N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide

POBN, N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide, N-(4-Pyridylmethylene)-tert-butylamine N,Nμ-dioxide

2-Methyl-N-[(pyridine 1-oxide)-4-ylmethylene]-2-propanamine oxide

4-Pyridyl-1-oxide-tert-butyl Nitrone

N-[(Pyridine 1-oxide)-4-ylmethylene]-tert-butylamineN-oxide

N-[[(Pyridine-1-oxide)-4-yl]methylene]-1,1-dimethylethanamine-N-oxide

N-tert-Butyl-α-(4-pyridyl-1-oxide)nitrone

alpha-(4-Pyridyl 1-oxide)-N-tert-butyl-nitrone,99%

N-tert-Butyl-alpha-(4-pyridyl)nitrone N'-Oxide POBN N-(4-Pyridylmethylene)-tert-butylamine N,N'-Dioxide alpha-(4-Pyridyl N-Oxide)-N-tert-butylnitrone

alpha-(4-Pyridyl N-oxide)-N-tert-butylnitrone ~95%

alpha-(4-Pyridyl N-oxide)-N-tert-butylnitrone 99%

-(4-pyridyl-1-oxide)nitrone

N-tert-Butyl-&alpha

(Z)-2-Methyl-N-((1-oxidopyridin-4-yl)methylene)propan-2-amine oxide

Dimethylaminoparthenolide/ Tert-Butyl-[(1-Oxido-4-Pyridylidene)Methyl]-Oxo-Ammonium

N-(4-PYRIDYLMETHYLENE)-TERT-BUTYLAMINE N,N'-DIOXIDE

N-TERT-BUTYL-ALPHA-(4-PYRIDYL-1-OXIDE)NITRONE

N-TERT-BUTYL-ALPHA-(4-PYRIDYL)-NITRONE N'-OXIDE

POBN

ALPHA-(4-PYRIDYL-1-OXIDE)-N-T-BUTYLNITRONE

ALPHA-(4-PYRIDYL 1-OXIDE)-N-TERT-BUTYLNITRONE

ALPHA-(4-PYRIDYL N-OXIDE)-N-TERT-BUTYLNITRONE

Butylpyridyloxidenitrone

N-tert-Butyl-alpha-(4-pyridyl-1-oxide)nitrone [spin trapping

1,1-dimethyl-N-(4-pyridylmethylene)ethylamine N,N'-dioxide

A-(4-PYRIDYL-N-OXIDE-N-TERT-BUTYLNITRONE

α-(4-pyridyl n-oxide)-n-tert-butylnitrone

N-TERT-BUTYL-A-(4-PYRIDYL)NITRONEN-OXIDE

N-TERT-BUTYL-ALPHA-(4-PYRIDYL-1-OXIDE)NITRONE [SPIN TRAPPING REAGENT]

N-tert-Butyl-alpha-(4-pyridyl-1-oxide)nitrone &gt

2-Propanamine, 2-methyl-N-[(1-oxido-4-pyridinyl)methylene]-, N-oxide

ert-butyl-[(1-oxidopyridin-4-ylidene)methyl]-oxoazanium

PYRIDYLOXIDE t-BUTYLNITRONE

α-(4-Pyridyl N-oxide)-N-tert-butylnitrone

66893-81-0

Building Blocks

C9 to C46

Spin Trapping Reagents

ESR Spectrometry

Heterocyclic Building Blocks

Pyridines

Analytical Chemistry

ESR Spectrometry

Spin Trapping Reagents

Analytical Reagents

Analytical/Chromatography

Building Blocks

C10

Chemical Synthesis

Electron Spin Resonance (ESR/EPR) Spectroscopy

Heterocyclic Building Blocks

Pyridines

Spectroscopy