AC-D-ALA-OME
- Product Name
- AC-D-ALA-OME
- CAS No.
- 19914-36-4
- Chemical Name
- AC-D-ALA-OME
- Synonyms
- AC-D-ALA-OME;AC-D-ALANINE-OME;N-Acetyl-D-alanine methyl;ACETYL-D-ALANINE METHYL ESTER;-Methyl 2-acetamidopropanoate;N-Acetyl-D-alanine methyl ester;(R)-Methyl 2-acetaMidopropanoate;methyl (2R)-2-acetamidopropanoate;D-Alanine, N-acetyl-, methyl ester;N-ALPHA-ACETYL-D-ALANINE METHYL ESTER
- CBNumber
- CB6718387
- Molecular Formula
- C6H11NO3
- Formula Weight
- 145.16
- MOL File
- 19914-36-4.mol
AC-D-ALA-OME Property
- Boiling point:
- 251.1℃
- Density
- 1.056
- Flash point:
- 105.7℃
- storage temp.
- Sealed in dry,2-8°C
- pka
- 14.78±0.46(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3533
- Product name
- Ac-D-Ala-OMe
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $169
- Updated
- 2025/07/31
- Product number
- A3533
- Product name
- Ac-D-Ala-OMe
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $508
- Updated
- 2025/07/31
- Product number
- A168073
- Product name
- N-Acetyl-D-alanineMethylEster
- Packaging
- 5g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 457973
- Product name
- N-Acetyl-D-alanine Methyl Ester
- Packaging
- 1g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- AS41807-2R
- Product name
- (R)-Methyl 2-acetamidopropanoate
- Purity
- 95% ee
- Packaging
- 25g
- Price
- $308
- Updated
- 2021/12/16
AC-D-ALA-OME Chemical Properties,Usage,Production
Chemical Properties
Yellow liquid
Uses
N-Acetyl-D-alanine Methyl Ester was used in preparation of chiral bis(phospholate)-rhodium complexesa s catalysts via asymmetric hydrogentation.
Synthesis
35356-70-8
19914-36-4
GENERAL METHODS: 438.5 mg (2.00 mmol) of the α-dehydroamino acid 2-(N-acetamido)-3-phenyl-2-propenoic acid methyl ester was used as a substrate for the reaction, and 1.55 mg of (2.RxR)-1,2-bis(tert-butylmethylphosphinato)-4,5-(methylenedioxy)benzyl)(1,5-cyclooctadienyl) rhodium (1+) hexafluoroantimonate was added as an asymmetric hydrogenation catalyst. The reaction system was purged five times with hydrogen and 5 mL of predegassed anhydrous methanol was added. Subsequently, the reaction was initiated by setting the hydrogen pressure to 3 atmospheres. After stirring at room temperature for 30 min, it was observed that the consumption of hydrogen stopped, indicating the completion of the reaction. The reaction solution was concentrated and the residual white crystals were dissolved in ethyl acetate and purified by silica gel column chromatography.HPLC analysis of the eluent afforded methyl (R)-2-(N-acetylamino)-3-phenylpropionate with an enantiomeric excess (ee) of 99.9%. In addition, the chemical yield of the compounds was confirmed to be 99% or higher by 1H NMR analysis (corresponding to No. 1 in Table 1).The HPLC conditions were as follows: a Daicel Chiralcel OJ column at a flow rate of 1.0 mL/min, a mobile phase of hexane:2-propanol (9:1), and the retention times of the enantiomers were (R)-13.3 min, (S)-19.3 Under the same asymmetric hydrogenation reaction conditions, only the reaction substrate and reaction conditions were changed (as shown in Table 1), and the reaction results are also listed in Table 1.
References
[1] Journal of the American Chemical Society, 1993, vol. 115, # 22, p. 10125 - 10138
[2] Journal of Organometallic Chemistry, 2001, vol. 621, # 1-2, p. 130 - 142
[3] Synthesis, 2004, # 9, p. 1353 - 1358
[4] Tetrahedron Letters, 2005, vol. 46, # 34, p. 5643 - 5646
[5] Tetrahedron Letters, 2006, vol. 47, # 25, p. 4263 - 4266
AC-D-ALA-OME Preparation Products And Raw materials
Raw materials
Preparation Products
AC-D-ALA-OME Suppliers
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