4-Benzyloxy-3-methylbenzeneboronic acid
- Product Name
- 4-Benzyloxy-3-methylbenzeneboronic acid
- CAS No.
- 338454-30-1
- Chemical Name
- 4-Benzyloxy-3-methylbenzeneboronic acid
- Synonyms
- oxy-3-methyL;AKOS BRN-0646;4-BENZYLOXY-3-METHYLPHENYLBORONIC ACID;(4-BENZYLOXY-3-METHYL)BENZENEBORONIC ACID;4-Benzyloxy-3-methylbenzeneboronicacid96%;4-Benzyloxy-3-methylbenzeneboronic acid 96%;(3-methyl-4-phenylmethoxyphenyl)boronic acid;Boronic acid, B-[3-methyl-4-(phenylmethoxy)phenyl]-;4-Benzyloxy-3-methylbenzeneboronic acid(contains varying amounts of Anhydride);4-Benzyloxy-3-methylphenylboronic Acid (contains varying amounts of Anhydride)
- CBNumber
- CB6723345
- Molecular Formula
- C14H15BO3
- Formula Weight
- 242.08
- MOL File
- 338454-30-1.mol
4-Benzyloxy-3-methylbenzeneboronic acid Property
- Melting point:
- 102-106
- Boiling point:
- 431.6±55.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- powder to crystal
- pka
- 8.74±0.17(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 338454-30-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- HazardClass
- IRRITANT
- HS Code
- 29310095
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B5169
- Product name
- 4-Benzyloxy-3-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $65
- Updated
- 2025/07/31
- Product number
- B5169
- Product name
- 4-Benzyloxy-3-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $192
- Updated
- 2025/07/31
- Product number
- B410903
- Product name
- 4-Benzyloxy-3-methylphenylboronicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- V1882
- Product name
- 4-Benzyloxy-3-methylphenylboronicacid
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- 40199
- Product name
- 4-Benzyloxy-3-methylphenylboronicacid,96-105%(Assaybytitration)
- Purity
- 96-105%(Assaybytitration)
- Packaging
- 1G
- Price
- $68.32
- Updated
- 2021/12/16
4-Benzyloxy-3-methylbenzeneboronic acid Chemical Properties,Usage,Production
Uses
suzuki reaction
Synthesis
338454-32-3
338454-30-1
General procedure for the synthesis of 4-benzyloxy-3-methylbenzeneboronic acid from 2-benzyloxy-5-bromotoluene: 4-bromo-1-benzyloxy-2-methylbenzene (6.9 g, 25 mmol) was dissolved in molecularly sieve-dried tetrahydrofuran (37.5 mL) and the solution was cooled to -78 °C. A n-hexane solution of 1.6 M n-butyllithium (17 mL, 27.5 mmol) was added slowly and dropwise over a period of 30 min, keeping the reaction temperature from exceeding -70 °C. After continued stirring at this temperature for 10 min, trimethyl borate (8.3 mL, 75 mmol) was added dropwise over 25 min below -70 °C. The reaction mixture was allowed to warm slowly to room temperature and stirred overnight. The reaction mixture was then cooled to 0 °C and aqueous 1 N hydrochloric acid was added dropwise. The reaction mixture was diluted with water and ethyl acetate to separate the organic and aqueous phases, and the aqueous phase was then extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated aqueous sodium chloride solution, dried with magnesium sulfate, filtered and concentrated. 4-Benzyloxy-3-methylphenylboronic acid 3.95 g (yield 65%) was obtained as a white powder. Mass spectrum (ISN): 301.2 (M-H)-.
References
[1] Patent: US6821980, 2004, B1. Location in patent: Page column 28
[2] Chemistry - A European Journal, 2000, vol. 6, # 20, p. 3821 - 3837
4-Benzyloxy-3-methylbenzeneboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Benzyloxy-3-methylbenzeneboronic acid Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from 4-Benzyloxy-3-methylbenzeneboronic acid manufacturers
- Product
- 4-Benzyloxy-3-methylbenzeneboronic acid 338454-30-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg; 100kg
- Release date
- 2019-07-03