7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester

Product Name: 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
CAS No.: 1599440-07-9
Chemical Name: 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
Synonyms: Fmoc-Gly-NH-CH2-O-CH2-Cbz;7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-d;Benzyl 2-[[2-(Fmoc-amino)acetamido]methoxy]acetate;benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaunde;benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oate;benzyl 2-[(2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido)methoxy]acetate;7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
CBNumber: CB67247521
Molecular Formula: C27H26N2O6
Formula Weight: 474.51
MOL File: 1599440-07-9.mol

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7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Property

Boiling point:: 733.0±60.0 °C(Predicted)
Density: 1.269±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, sealed storage, away from moisture
form: Solid
pka: 10.58±0.46(Predicted)
color: White to off-white
InChIKey: MZOSSDIBSRKPCO-UHFFFAOYSA-N
SMILES: C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCC(=O)NCOCC(=O)OCC1=CC=CC=C1

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Hazard and Precautionary Statements (GHS)

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7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Chemical Properties,Usage,Production

Uses

7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester is an important organic intermediate. It can be used to synthesize camptothecin derivatives and other anticancer organic compounds, and then synthesize antibody-drug conjugate.

Definition

7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester is also known as Benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oate.

Preparation

(2-((((9H-fluorene-9-yl)methoxy)carbonyl)amino)acetamido)methyl acetate (7.36 g, 20.0 mmol), THF, and p-toluenesulfonic acid monohydrate (0.38 g, 2.00 mmol) were added to a single-neck bottle at 0°C. Benzyl glycolate (6.65 g, 40.0 mmol) was added dropwise and the temperature was naturally raised to room temperature for 2-4h. TLC monitoring this reaction. After the reaction was completed, saturated NaHCO3 solution was added to quench the reaction, extracted with ethyl acetate, and washed with saturated sodium chloride solution. After dried over anhydrous sodium sulfate, filtered, concentrated, and the residue was purified by column chromatography to obtain 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester.

7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Suppliers

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View Lastest Price from 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester 1599440-07-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

1599440-07-9, 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl esterRelated Search:

7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester

benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaunde

7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-d

benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oate

Fmoc-Gly-NH-CH2-O-CH2-Cbz

Benzyl 2-[[2-(Fmoc-amino)acetamido]methoxy]acetate

benzyl 2-[(2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido)methoxy]acetate

1599440-07-9