7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- Product Name
- 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- CAS No.
- 1599440-07-9
- Chemical Name
- 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- Synonyms
- Fmoc-Gly-NH-CH2-O-CH2-Cbz;7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-d;Benzyl 2-[[2-(Fmoc-amino)acetamido]methoxy]acetate;benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaunde;benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oate;benzyl 2-[(2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido)methoxy]acetate;7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- CBNumber
- CB67247521
- Molecular Formula
- C27H26N2O6
- Formula Weight
- 474.51
- MOL File
- 1599440-07-9.mol
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Property
- Boiling point:
- 733.0±60.0 °C(Predicted)
- Density
- 1.269±0.06 g/cm3(Predicted)
- pka
- 10.58±0.46(Predicted)
- form
- Solid
- color
- White to off-white
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Chemical Properties,Usage,Production
Uses
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester is an important organic intermediate. It can be used to synthesize camptothecin derivatives and other anticancer organic compounds, and then synthesize antibody-drug conjugate.
Definition
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester is also known as Benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oate.
Preparation
(2-((((9H-fluorene-9-yl)methoxy)carbonyl)amino)acetamido)methyl acetate (7.36 g, 20.0 mmol), THF, and p-toluenesulfonic acid monohydrate (0.38 g, 2.00 mmol) were added to a single-neck bottle at 0°C. Benzyl glycolate (6.65 g, 40.0 mmol) was added dropwise and the temperature was naturally raised to room temperature for 2-4h. TLC monitoring this reaction. After the reaction was completed, saturated NaHCO3 solution was added to quench the reaction, extracted with ethyl acetate, and washed with saturated sodium chloride solution. After dried over anhydrous sodium sulfate, filtered, concentrated, and the residue was purified by column chromatography to obtain 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester.
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Preparation Products And Raw materials
Raw materials
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View Lastest Price from 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester manufacturers
- Product
- 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester 1599440-07-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13