7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- Product Name
- 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- CAS No.
- 1599440-07-9
- Chemical Name
- 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- Synonyms
- Fmoc-Gly-NH-CH2-O-CH2-Cbz;7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-d;Benzyl 2-[[2-(Fmoc-amino)acetamido]methoxy]acetate;benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaunde;benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oate;9H-Fluoren-9-ylmethyl 4,9-dioxo-11-phenyl-7,10-dioxa-2,5-diazaundecanoate;benzyl 2-[(2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido)methoxy]acetate;7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- CBNumber
- CB67247521
- Molecular Formula
- C27H26N2O6
- Formula Weight
- 474.51
- MOL File
- 1599440-07-9.mol
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Property
- Boiling point:
- 733.0±60.0 °C(Predicted)
- Density
- 1.269±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, sealed storage, away from moisture
- form
- Solid
- pka
- 10.58±0.46(Predicted)
- color
- White to off-white
- InChIKey
- MZOSSDIBSRKPCO-UHFFFAOYSA-N
- SMILES
- C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCC(=O)NCOCC(=O)OCC1=CC=CC=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Chemical Properties,Usage,Production
Uses
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester is an important organic intermediate. It can be used to synthesize camptothecin derivatives and other anticancer organic compounds, and then synthesize antibody-drug conjugate.
Definition
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester is also known as Benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oate.
Preparation
(2-((((9H-fluorene-9-yl)methoxy)carbonyl)amino)acetamido)methyl acetate (7.36 g, 20.0 mmol), THF, and p-toluenesulfonic acid monohydrate (0.38 g, 2.00 mmol) were added to a single-neck bottle at 0°C. Benzyl glycolate (6.65 g, 40.0 mmol) was added dropwise and the temperature was naturally raised to room temperature for 2-4h. TLC monitoring this reaction. After the reaction was completed, saturated NaHCO3 solution was added to quench the reaction, extracted with ethyl acetate, and washed with saturated sodium chloride solution. After dried over anhydrous sodium sulfate, filtered, concentrated, and the residue was purified by column chromatography to obtain 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester.
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester manufacturers
- Product
- 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester 1599440-07-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13