GOMISIN N
- Product Name
- GOMISIN N
- CAS No.
- 69176-52-9
- Chemical Name
- GOMISIN N
- Synonyms
- GOMISIN N;Gomisin N Standard;Gomisin N, 10 mM in DMSO;Benzo(3,4)cycloocta(1,2-F)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13as)-
- CBNumber
- CB6731526
- Molecular Formula
- C23H28O6
- Formula Weight
- 400.46
- MOL File
- 69176-52-9.mol
GOMISIN N Property
- alpha
- -22～-32°(D/20℃)(c=0.25,CH3CN)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- White to off-white
- InChI
- InChI=1/C23H28O6/c1-12-7-14-9-16(24-3)20(25-4)22(26-5)18(14)19-15(8-13(12)2)10-17-21(23(19)27-6)29-11-28-17/h9-10,12-13H,7-8,11H2,1-6H3/t12-,13+/s3
- InChIKey
- RTZKSTLPRTWFEV-JNEKIBDFNA-N
- SMILES
- O1C2=C(OC)C3C4=C(OC)C(OC)=C(OC)C=C4C[C@@H](C)[C@@H](C)CC=3C=C2OC1 |&1:19,21,r|
- LogP
- 6.460 (est)
N-Bromosuccinimide Price
- Product number
- G766613
- Product name
- GomisinN
- Packaging
- 0.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-0027857
- Product name
- GomisinN
- Purity
- ≥99.0%
- Packaging
- 5mg
- Price
- $336
- Updated
- 2021/12/16
- Product number
- orb259278
- Product name
- Gomisin N
- Purity
- 98%
- Packaging
- 10mg
- Price
- $513.4
- Updated
- 2021/12/16
- Product number
- CS-0027857
- Product name
- GomisinN
- Purity
- ≥99.0%
- Packaging
- 10mg
- Price
- $571
- Updated
- 2021/12/16
- Product number
- orb259278
- Product name
- Gomisin N
- Purity
- 98%
- Packaging
- 20mg
- Price
- $591.6
- Updated
- 2021/12/16
GOMISIN N Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Schisandra chinensis.
Uses
Gomisin N, isolated from Schisandra chinensis. Gomisin N has the potential for use in the treatment of allergy. Gomisin N is an anti-cancer agent candidate capable of inhibiting the proliferation and inducing the apoptosis in cancer[1][2][3].
Definition
ChEBI: (+)-schisandrin B is an organic heterotetracyclic compound that is found in Fructus Schisandrae and Schisandra chinensis. It has a role as a nephroprotective agent, an apoptosis inhibitor, a plant metabolite, an anti-asthmatic agent, an antioxidant, an anti-inflammatory agent, a neuroprotective agent, a hepatoprotective agent and an antilipemic drug. It is an organic heterotetracyclic compound, an aromatic ether, an oxacycle and a cyclic acetal.
References
[1] Inoue H, et al. Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5. Int J Oncol. 2012 Apr;40(4):1058-65.
[2] Jung DY, et al. Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):587-593.
[3] Oh SY, et al. Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Biosci Biotechnol Biochem. 2010;74(2):285-91.
[4] Jang MK, et al. Gomisin N inhibits adipogenesis and prevents high-fat diet-induced obesity. Sci Rep. 2017 Jan 9;7:40345.
[5] Zhu PL, et al. Gomisin N Exerts Anti-liver Cancer Effects and Regulates PI3K-Akt and mTOR-ULK1 Pathways in Vitro. Biol Pharm Bull. 2020;43(8):1267-1271.
[6] Yim SY, et al. Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma. Mol Med Rep. 2009 Sep-Oct;2(5):725-32. DOI:10.3892/mmr_00000163
[7] Takimoto Y, et al. Gomisin N in the herbal drug gomishi (Schisandra chinensis) suppresses inducible nitric oxide synthase gene via C/EBPβ and NF-κB in rat hepatocytes. Nitric Oxide. 2013 Jan 15;28:47-56.
[8] Jang MK, et al. Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis. Biol Pharm Bull. 2016 May 1;39(5):832-8.
[9] Chae JK, et al. Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes. Int J Mol Sci. 2017 Feb 22;18(2):471.
[10] Song M, et al. Gomisin N rescues cognitive impairment of Alzheimer's disease by targeting GSK3β and activating Nrf2 signaling pathway. Phytomedicine. 2024 Sep;132:155811.
GOMISIN N Preparation Products And Raw materials
Raw materials
Preparation Products
GOMISIN N Suppliers
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View Lastest Price from GOMISIN N manufacturers
- Product
- Gomisin N 69176-52-9
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-09
- Product
- GOMISIN N 69176-52-9
- Price
- US $8.00/KG
- Min. Order
- 1g
- Purity
- ＞98% HPLC
- Supply Ability
- kg--ton
- Release date
- 2020-02-20