BENZYLOXYACETONE

Product Name: BENZYLOXYACETONE
CAS No.: 22539-93-1
Chemical Name: BENZYLOXYACETONE
Synonyms: BENZYLOXYACETONE;1-(Benzyloxy)acetone;Benzyloxyacetone 90%;3-benzyloxypropanone;1-BENZYLOXY-2-PROPANONE;1-(Benzyloxy)propan-2-one;1-(Benzyloxy)propane-2-one;1-phenylmethoxypropan-2-one;1-phenylmethoxy-2-propanone;2-Propanone, 1-(phenylMethoxy)-
CBNumber: CB6736228
Molecular Formula: C10H12O2
Formula Weight: 164.2
MOL File: 22539-93-1.mol

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BENZYLOXYACETONE Property

Boiling point:: 259 °C (lit.)
Density: 1.04 g/mL at 25 °C (lit.)
refractive index: n20/D 1.512(lit.)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C10H12O2/c1-9(11)7-12-8-10-5-3-2-4-6-10/h2-6H,7-8H2,1H3
InChIKey: YHMRKVGUSQWDGZ-UHFFFAOYSA-N
SMILES: C(OCC1=CC=CC=C1)C(=O)C

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 489174
Product name: Benzyloxyacetone
Purity: 90%
Packaging: 5g
Price: $196
Updated: 2025/07/31

TRC

Product number: B289158
Product name: 1-(Benzyloxy)propan-2-one
Packaging: 500mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: 1360AB
Product name: 1-(Benzyloxy)propan-2-one
Packaging: 25g
Price: $1072
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0156481
Product name: BENZYLOXYACETONE
Purity: 95.00%
Packaging: 5G
Price: $938.28
Updated: 2021/12/16

Matrix Scientific

Product number: 143289
Product name: 1-(Benzyloxy)propan-2-one
Purity: 97%
Packaging: 1g
Price: $240
Updated: 2021/12/16

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BENZYLOXYACETONE Chemical Properties,Usage,Production

Uses

Benzyloxyacetone (1-Benzyloxy-2-propanone) may be used in the synthesis of:

7-benzyloxy-6-methyl-5-hepten-1-yne
(Z)-2-methylhept-2-en-6-yn-1-o1
(S)-(+)-1,2-propanediol, 1-benzyl ether

It may be used as a starting material in synthesizing (2S,4RS)-4-acetoxy-2-[(benzyloxy)methyl]-2-methyldioxolane and (2R,4RS)-4-acetoxy-2-[(benzyloxy)methyl]-2-methyldioxolane.

General Description

Benzyloxyacetone (α-Benzyloxyacetone) is an α-substituted acetone. It undergoes direct aldol reaction with 4-nitrobenzaldehyde in the presence of (S)-BINAM-L-prolinamide/benzoic acid to form predominantly the syn-diasteroisomer.

Synthesis

14593-43-2

22539-93-1

To a stirred mixed solution of allyl benzyl ether (0.4 mmol) in acetonitrile (3.5 mL) and water (0.5 mL) was added palladium dichloride (PdCl2, 3.6 mg, 0.02 mmol, 5 mol%) and chromium trioxide (CrO3, 20 mg, 0.6 mmol, 0.5 eq.), in that order, at room temperature. The reaction mixture was heated to 60°C and stirred in a closed flask for the indicated time (refer to Table 5-7). Upon completion of the reaction, the mixture was filtered through a small silica gel pad and washed with ethyl acetate (EtOAc), followed by concentration of the filtrate. In some cases, the residue is almost pure in the residue and no further purification is required. In the remaining cases, the residue needs to be purified by silica gel column chromatography using petroleum ether/ethyl acetate (EtOAc) as eluent to finally obtain benzyloxyacetone.

References

[1] Tetrahedron, 2014, vol. 70, # 32, p. 4760 - 4767
[2] Journal of Organic Chemistry, 2016, vol. 81, # 5, p. 2113 - 2121
[3] Journal of Organic Chemistry, 2014, vol. 79, # 12, p. 5787 - 5793
[4] Tetrahedron Letters, 2013, vol. 54, # 19, p. 2293 - 2295
[5] Tetrahedron Letters, 2009, vol. 50, # 24, p. 2893 - 2894

BENZYLOXYACETONE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZYLOXYACETONE Suppliers

China 75 Germany 1 India 3 Switzerland 1 United States 8 Global 88

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
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Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
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Aladdin Scientific

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Combi-Blocks Inc.

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Riedel-de Haen AG

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ProdList: 6773
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Matrix Scientific

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Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

ASDI Incorporated

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Email: customerservice@asdi.net
Country: United States
ProdList: 6922
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Advanced Synthesis Technologies

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Country: United States
ProdList: 4775
Advantage: 61

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View Lastest Price from BENZYLOXYACETONE manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: BENZYLOXYACETONE 22539-93-1
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 98
Supply Ability: 100kg
Release date: 2023-02-28

22539-93-1, BENZYLOXYACETONERelated Search:

Algestone acetophenide NARINGENIN Fluorescamine CHALCONE ALPHA,BETA-EPOXIDE DESYL BENZOATE BENZOYLOXYPHLORACETOPHENONE,OMEGA-(RG) TRANS-1,3-DIPHENYL-2,3-EPOXYPROPAN-1-ONE [2-(BENZYLOXY)PHENYL][3-(2,4,6-TRIMETHOXYPHENYL)OXIRAN-2-YL]METHANONE [2-(BENZYLOXY)PHENYL][3-(3,4-DICHLOROPHENYL)OXIRAN-2-YL]METHANONE (2-[(4-NITROBENZYL)OXY]PHENYL)(3-PHENYLOXIRAN-2-YL)METHANONE [2-(BENZYLOXY)PHENYL][3-(4-CHLOROPHENYL)OXIRAN-2-YL]METHANONE [3-(3,4-DIMETHOXYPHENYL)OXIRAN-2-YL](PHENYL)METHANONE [3-(1,3-BENZODIOXOL-5-YL)OXIRAN-2-YL](3,4-DIMETHOXYPHENYL)METHANONE (2R,6S)-(+)-4-BENZOYLOXY-2-BENZOYLOXYMETHYL-6-METHOXY-2H-PYRAN-3(6H)-ONE [2-(BENZYLOXY)PHENYL][3-(3,4,5-TRIMETHOXYPHENYL)OXIRAN-2-YL]METHANONE [2-(BENZYLOXY)PHENYL](3-PHENYLOXIRAN-2-YL)METHANONE [2-(METHOXYMETHOXY)PHENYL][3-(4-NITROPHENYL)OXIRAN-2-YL]METHANONE [2-(BENZYLOXY)-5-NITROPHENYL](3-PHENYLOXIRAN-2-YL)METHANONE

1-BENZYLOXY-2-PROPANONE

BENZYLOXYACETONE

1-(Benzyloxy)acetone

1-(Benzyloxy)propane-2-one

1-(Benzyloxy)propan-2-one

2-Propanone, 1-(phenylMethoxy)-

Benzyloxyacetone 90%

1-phenylmethoxy-2-propanone

3-benzyloxypropanone

1-phenylmethoxypropan-2-one

22539-93-1

C6H5CH2OCH2COCH3

Carboxylic Acids

Carbonyl Compounds

C10

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