Cefonicid sodium

ChemicalBook > CAS DataBase List > Cefonicid sodium

Product Name: Cefonicid sodium
CAS No.: 61270-78-8
Chemical Name: Cefonicid sodium
Synonyms: SKF D-75073-Z2;Monocid sodium;CEFONICID SODIUM;Cefonicid sodiumr;CEFONICID DISODIUM;Cefonicid Sodium (1 g);CEFONICID DISODIUM SALT;Cefonicid (sodium salt);CefonicidSodium(Sterile);Cefonicid sodium USP/EP/BP
CBNumber: CB6743497
Molecular Formula: C18H19N6NaO8S3
Formula Weight: 566.55
MOL File: 61270-78-8.mol

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Cefonicid sodium Property

Melting point:: > 160°C
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Pale Yellow
CAS DataBase Reference: 61270-78-8(CAS DataBase Reference)

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Safety

HS Code: 2941906000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18745
Product name: Cefonicid (sodium salt)
Purity: ≥98%
Packaging: 100mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18745
Product name: Cefonicid (sodium salt)
Purity: ≥98%
Packaging: 500mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18745
Product name: Cefonicid (sodium salt)
Purity: ≥98%
Packaging: 1g
Price: $341
Updated: 2024/03/01

TRC

Product number: C242878
Product name: CefonicidSodium
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC50064
Product name: Cefonicid sodium
Packaging: 1g
Price: $60
Updated: 2021/12/16

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Cefonicid sodium Chemical Properties,Usage,Production

Description

Cefonicid sodium is the first of the second-generation cephalosporin antibiotics with a long enough serum half-life b4.5 hr.) to allow once-daily i.v. administration. Cefonicid is resistant to β-lactamases produced by S. aureus, H. influenzae, -N. gonorrhea, and related organisms. As with other drugs of this class, it is useful in the treatment of urinary tract and lower respiratory tract infections, skin and skin structure infections, and bone and joint infections, as well as in surgical prophylaxis.

Description

Cefonicid is a second-generation cephalosporin antibiotic. Like other cephalosporins, cefonicid interferes with cell wall biosynthesis in bacteria, leading to lysis of the infectious organism. It is a broad-spectrum antibiotic and has a prolonged serum elimination half-life in animals.

Chemical Properties

White Powder

Originator

Smith Kline & French (USA)

Uses

A semi-synthetic cephalosporin antibiotic related to Cefamandole. Antibacterial.

Definition

ChEBI: Cefonicid sodium is an organic sodium salt. It contains a cefonicid(2-).

brand name

MONOCID

Clinical Use

Cefonicid Sodium (Monocid) is a second-generationcephalosporin that is structurally similar to cefamandole,except that it contains a methane sulfonic acid groupattached to the N-1 position of the tetrazole ring. Theantimicrobial spectrum and limited β-lactamase stabilityof cefonicid are essentially identical with those ofcefamandole.
Cefonicid is unique among the second-generationcephalosporins in that it has an unusually long serum halflifeof approximately 4.5 hours. High plasma protein bindingcoupled with slow renal tubular secretion are apparentlyresponsible for the long duration of action. Despite the high fraction of drug bound in plasma, cefonicid is distributedthroughout body fluids and tissues, with the exception of thecerebrospinal fluid.
Cefonicid is supplied as a highly water-soluble disodiumsalt, in the form of a sterile powder to be reconstituted forinjection. Solutions are stable for 24 hours at 25°C and for72 hours when refrigerated.

in vitro

cefonicid was found to be similar to cefamandole in its superiority to first generation cephalosporins against several enterobacteriaceae and haemophilus influenzae, such as beta-lactamase-producing strains. its activity against staphylococcus aureus was similar to that of cefoxitin and inferior to cefamandole and first generation cephalosporins. cefonicid has excellent in-vitro activity against neisseria gonorrhoeae, but is inactive against pseudomonas, serratia, acinetobacter, and bacteroides fragilis [1].

in vivo

the purpose of a previous study was to determine whether cefonicid caused testicular toxicity when subcutaneously administered to sprague-dawley male rats at doses of 50 to 1,000 mg/kg per day. the histological findings were confirmed by marked reductions in testicular sperm production rates and cauda epididymal sperm numbers. in addition, cefonicid had no treatment-related adverse effects on the sexual maturation males [2].

References

[1] saltiel, e; brogden, r. n. (1986). cefonicid. a review of its antibacterial activity, pharmacological properties and therapeutic use. drugs. 32 (3): 222–59.
[2] manson jm, zolna le, kang yj, johnson cm. effects of cefonicid and other cephalosporin antibiotics on male sexual development in rats. antimicrob agents chemother. 1987 jul;31(7):991-7.

Cefonicid sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cefonicid sodium manufacturers

HebeiShuoshengImportandExportco.,Ltd

Product: Cefonicid sodium 61270-78-8
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-05

Hebei Longbang Technology Co., Ltd

Product: Cefonicid sodium 61270-78-8
Price: US $6.00/kg
Min. Order: 1kg
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-05-24

Hebei Jingbo New Material Technology Co., Ltd

Product: Cefonicid sodium 61270-78-8
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200000
Release date: 2023-12-29

61270-78-8, Cefonicid sodiumRelated Search:

Acetamide Sodium alginate Acetyl chloride Sodium benzoate Thioacetamide Sodium bicarbonate Acetaminophen 2-HYDROXYACETAMIDE Sodium citrate PHENYL VALERATE Trisodium phosphate Sodium chloride Acetyl coenzyme A sodium salt 5-Mercapto-1H-tetrazole-1-methane sulphonic acid Sodium acetate Acetylacetone CHLOROPHOSPHONAZO III Diclofenac sodium

disodium (6r,7r)-7-[[(2r)-2-hydroxy-2-phenyl-acetyl]amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

CEFONICID DISODIUM

CEFONICID SODIUM

5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[(HYDROXYPHENYLACETYL)AMINO]-8-OXO-3-[[[1-(SULFOMETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-, DISODIUM SALT

CEFONICID SODIUM[5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[(HYDROXYPHENYLACETYL)AMINO]-8-OXO-3-[[[1-(SULFOMETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-, DISODIUM SALT]

CEFONICID DISODIUM SALT

CefonicidDisodiumC18H16N6Na2O8S3

CefonicidSodium(Sterile)

(6R,7R)-7α-[[(R)-Hydroxyphenylacetyl]amino]-8-oxo-3-[[[1-(sodiooxysulfonylmethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt

SKF D-75073-Z2

Cefonicid Sodium (1 g) (COLD SHIPMENT REQUIRED)

Cefonicid Sodium (1 g)

Cefonicid (sodium salt)

Monocid sodium

sodium (6R,7R)-7-((R)-2-hydroxy-2-phenylacetamido)-8-oxo-3-(((1-(sulfonatomethyl)-1H-tetrazol-5-yl)thio)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Cefonicid sodium USP/EP/BP

Cefonicid sodiumr

Cefonicid Sodium (COLD SHIPMENT REQUIRED) (1097750)

61270-78-8

156-1-48

99-0-4

C18H16N6O8S32Na

C18H16N6Na2O8S3

C18H18N6Na2O8S3