2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL

Product Name: 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
CAS No.: 269409-97-4
Chemical Name: 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL
Synonyms: St5405622;522554_Aldrich;2-HYDROXYPHENYLBORONIC ACID, PINACOL ESTER;2-HYDROXYBENZENEBORONIC ACID, PINACOL ESTER;2-Hydroxyphenylboronic acid pinacol ester 98%;2-(Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol;2-HYDROXYPHENYLBORONIC ACID, PINACOL CYCLIC ESTER;2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL;Phenol, 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol,97%
CBNumber: CB6748407
Molecular Formula: C12H17BO3
Formula Weight: 220.07
MOL File: 269409-97-4.mol

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2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Property

Boiling point:: 282 °C(lit.)
Density: 1.05 g/mL at 25 °C(lit.)
refractive index: n20/D 1.506(lit.)
Flash point:: 230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Water Solubility: Insoluble in water
form: liquid
pka: 10.17±0.35(Predicted)
color: pale yellow
CAS DataBase Reference: 269409-97-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
TSCA: No
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 522554
Product name: 2-Hydroxyphenylboronic acid pinacol ester
Purity: 98%
Packaging: 5g
Price: $250
Updated: 2025/07/31

Sigma-Aldrich

Product number: 522554
Product name: 2-Hydroxyphenylboronic acid pinacol ester
Purity: 98%
Packaging: 1g
Price: $53.8
Updated: 2023/06/20

TCI Chemical

Product number: T1952
Product name: 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
Purity: >97.0%(GC)
Packaging: 1g
Price: $63
Updated: 2025/07/31

TCI Chemical

Product number: T1952
Product name: 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
Purity: >97.0%(GC)
Packaging: 5g
Price: $189
Updated: 2025/07/31

Strem Chemicals

Product number: 05-1042
Product name: 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, min. 97%
Packaging: 1g
Price: $100
Updated: 2024/03/01

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2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Chemical Properties,Usage,Production

Chemical Properties

pale yellow to brown liquid

Uses

Reactant involved in:

Synthesis of indolo-fused heterocyclic inhibitors of polymerase enzyme of hepatitis C
Studies of pi-interactions, electronic structure and transient UV absorption of subphthalocyanine-borate-bridged ferrocene-fullerene conjugates
Synthesis of subphthalocyanine and fused-ring nicotine derivatives
Suzuki-Miyaura coupling-triflation sequence, reduction and salt formation for synthesis of hydroxylated oligoarene phosphines

Uses

2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)phenol can be widely used in Suzuki coupling chemistry.

Synthesis

95-55-6

73183-34-3

269409-97-4

GENERAL PROCEDURE: To a solution of o-aminophenol (0.5 mmol, 1.0 eq.) in methanol (1.0 mL) was added hydrochloric acid (0.5 mL, 1.5 mmol, 3.0 eq.) followed by water (0.5 mL). The mixture was stirred for 2 minutes and then sodium nitrite solution (0.25 mL) was added. Sodium nitrite solution was prepared by dissolving 35 mg of sodium nitrite in water (0.25 mL). The mixture was stirred at 0-5°C for 30 minutes, followed by the addition of a methanol (1.0 mL) solution of pinacol ester of bisboronic acid (2,381 mg, 1.5 mmol, 3.0 equiv). The reaction mixture was stirred for 60 minutes. Upon completion of the reaction, it was diluted with water (10 mL) and then extracted with dichloromethane (50 mL, 3 times). The organic layers were combined, washed with saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate, concentrated and the crude product was purified by fast chromatography to give 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol.

References

[1] Synlett, 2014, vol. 25, # 11, p. 1577 - 1584
[2] Journal of Organic Chemistry, 2013, vol. 78, # 5, p. 1923 - 1933

2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL Suppliers

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View Lastest Price from 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL manufacturers

Career Henan Chemical Co

Product: 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL 269409-97-4
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: ask
Release date: 2018-12-20

269409-97-4, 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOLRelated Search:

2-CHLORO-6-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL 2-METHOXYPHENYLBORONIC ACID PINACOL ESTER 2-TERT-BUTOXYCARBONYLOXYPHENYLBORONIC ACID, PINACOL ESTER 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL ACETATE 4-Hydroxyphenylboronic acid pinacol ester 2,6-DIMETHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL 2-Hydroxyphenylboronic acid 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL [2-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-acetonitrile 2-BENZYLOXYPHENYLBORONIC ACID, PINACOL ESTER 2-[2-([1,3]DIOXOLAN-2-YLMETHOXY)-PHENYL]-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE 4,4,5,5-TETRAMETHYL-2-[2-(2,2,2-TRIFLUORO-ETHOXY)-PHENYL]-[1,3,2]DIOXABOROLANE 3,5-DIFLUORO-2-METHOXYPHENYLBORONIC ACID, PINACOL ESTER 2-(5-[1,3]DIOXOLAN-2-YL-2,4-DIMETHOXY-PHENYL)-BORONIC ACID PINACOL ESTER 2-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID, PINACOL ESTER 2,4-DIMETHOXYPHENYLBORONIC ACID, PINACOL ESTER 2-METHOXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol,min.97%

2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL, MIN. 97%

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol,97%

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, 2-(2-Hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

(3-hydroxy-2,3-dimethylbutan-2-yl)oxy-(2-hydroxyphenyl)borinic acid

Phenol, 2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

2-(2-Hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-Hydroxyphenylboronic Acid Pinacol Ester

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol 2-Hydroxyphenylboronic Acid Pinacol Ester

522554_Aldrich

St5405622

2-Hydroxyphenylboronic acid pinacol ester 98%

2-(Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

2-HYDROXYBENZENEBORONIC ACID, PINACOL ESTER

2-HYDROXYPHENYLBORONIC ACID, PINACOL CYCLIC ESTER

2-HYDROXYPHENYLBORONIC ACID, PINACOL ESTER

2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL

2-(2-HYDROXYPHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol - [T3760]

269409-97-4

Aryl

Boronate Esters

Boronic Acids and Derivatives

Boronic Acids Esters

B (Classes of Boron Compounds)

Organometallic Reagents

Boronic Acids and Derivatives

Chemical Synthesis

Organometallic Reagents

Aryl Boronate Esters

Boronate Esters

organic or inorganic borate

Boronic acids

B (Classes of Boron Compounds)

Boronic Acids Esters