4-Fluoro-2-methylbenzaldehyde
- Product Name
- 4-Fluoro-2-methylbenzaldehyde
- CAS No.
- 63082-45-1
- Chemical Name
- 4-Fluoro-2-methylbenzaldehyde
- Synonyms
- 4-Fluoro-o-tolualdehyde;5-Fluoro-2-formyltoluene;2-methyl-4-fluorobenzaldehyde;4-FLUORO-2-METHYLBENZALDEHYDE;Benzaldehyde, 4-fluoro-2-methyl-;4-Fluoro-2-methylbenzaldehyde>4-Fluoro-2-methylbenzaldehyde 97%;Benzaldehyde, 4-fluoro-2-methyl- (9CI);5-Fluoro-2-formyltoluene, 4-Fluoro-o-tolualdehyde
- CBNumber
- CB6752756
- Molecular Formula
- C8H7FO
- Formula Weight
- 138.14
- MOL File
- 63082-45-1.mol
4-Fluoro-2-methylbenzaldehyde Property
- Boiling point:
- 87 14mm
- Density
- 1.144 g/mL at 25 °C
- refractive index
- 1.5260
- Flash point:
- 82 °C
- storage temp.
- Inert atmosphere,2-8°C
- form
- clear liquid
- color
- Colorless to Almost colorless
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 63082-45-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41-37/38
- Safety Statements
- 26-36-39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29130000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0793
- Product name
- 4-Fluoro-2-methylbenzaldehyde
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- F0793
- Product name
- 4-Fluoro-2-methylbenzaldehyde
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $44
- Updated
- 2025/07/31
- Product number
- F401565
- Product name
- 4-Fluoro-2-methylbenzaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2715-3-X1
- Product name
- 4-Fluoro-2-methylbenzaldehyde
- Packaging
- 5G
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC10436
- Product name
- 4-Fluoro-2-methylbenzaldehyde
- Purity
- 95%
- Packaging
- 25g
- Price
- $99
- Updated
- 2021/12/16
4-Fluoro-2-methylbenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to light yellow liquid
Uses
4-FLUORO-2-METHYLBENZALDEHYDE is a useful research chemical.
Synthesis
452-63-1
68-12-2
63082-45-1
Example 1: This example illustrates the synthesis of 4-fluoro-2-methylbenzaldehyde (see Figure III, Scheme I). The procedure was as follows: 2-bromo-5-fluorotoluene (37.5 mL, 56.1 g, 297 mmol) was dissolved in 500 mL of anhydrous tetrahydrofuran (THF) and the solution was cooled to -78 °C. A hexane solution of 2.5 M butyllithium (119 mL, 297 mmol, 1.0 eq.) was slowly added over 35 min at -75 to -78 °C, followed by stirring of the reaction mixture at -78 °C for 20 min. Dry N,N-dimethylformamide (27.6 mL, 26.0 g, 356 mmol, 1.2 eq.) was added over 26 min at the same temperature range. After addition, the reaction solution was continued to be stirred at -78 °C for 60 min, and then slowly warmed to 15 °C, taking about 2 hours. An aqueous ammonium chloride solution (100 g, 15.9%) was added over 5 min at 15-20 °C. The reaction mixture was concentrated by fractional distillation (50-61°C fractions were collected, totaling 597 mL) and the distillate layer was separated. The aqueous layer was extracted three times with methyl tert-butyl ether (MTBE, 25 mL x 3). The organic layers were combined, washed with 50 mL of saturated brine, dried over anhydrous magnesium sulfate, filtered and fractionated again (boiling point 54-62 °C) to give 59.3 g of yellow oil. The crude product was further purified by fractional distillation under reduced pressure (boiling point 60-62 °C, pressure 1.6-2.0 mmHg) to finally obtain 28.041 g (68.4% yield) of the target product 4-fluoro-2-methylbenzaldehyde in the form of a colorless oil.
Purification Methods
The aldehyde has been purified by gas chromatography and should be kept under N2 as it readily oxidizes in air [Burgess et al. Aust J Chem 30 543 1977].
References
[1] Patent: WO2004/110996, 2004, A1. Location in patent: Page/Page column 17-18
[2] Patent: WO2005/37763, 2005, A1. Location in patent: Page/Page column 82
[3] Patent: US2006/14959, 2006, A1. Location in patent: Page/Page column 10
[4] Organic Process Research and Development, 2006, vol. 10, # 6, p. 1157 - 1166
[5] Patent: EP1787991, 2007, A1. Location in patent: Page/Page column 45
4-Fluoro-2-methylbenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-2-methylbenzaldehyde manufacturers
- Product
- 4-Fluoro-2-methylbenzaldehyde 63082-45-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-13
- Product
- 4-Fluoro-2-methylbenzaldehyde 63082-45-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08